| Project/Area Number |
16K11755
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
KIBE TOSHIRO 鹿児島大学, 医歯学域歯学系, 助教 (50635480)
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| Co-Investigator(Kenkyū-buntansha) |
中村 典史 鹿児島大学, 医歯学域歯学系, 教授 (60217875)
岸田 昭世 鹿児島大学, 医歯学域医学系, 教授 (50274064)
田口 哲志 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, グループリーダー (70354264)
渕上 貴央 鹿児島大学, 医歯学域附属病院, 助教 (40772439)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 瘢痕拘縮 / 上皮欠損 / 筋線維芽細胞 / 創傷被覆材 / 創傷治癒 / 口唇口蓋裂 / 血管新生 / 被覆材 / 瘢痕収縮 |
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| Outline of Final Research Achievements |
It is desirable for wound healing without scar contraction and scar contracture after surgery after oral and maxillofacial regions such as cleft lip and palate and oral cancer. However, a wound dressing having a function to realize this has not been developed yet. Therefore, we applied a hydroadhesive gelatin-derived bioadhesive porous membrane (HxAlGltn) developed by the National Research Organization for Materials and Materials (NIMS) as a wound dressing. We examined the effect on wound healing in rat skin.
We analyzed the effect of HxAlGltn on wound healing using an animal model. In this study, HxAlGltn promoted angiogenesis, and showed epithelial thickness close to normal tissue, expression of collagen type 1, and scar contraction effect. However, there was no promoting effect on epithelialization, and wound closure tended to be delayed. (Kibe et. Al. During submission) This result suggested the need to analyze the influence on epithelial cells in a cell biological way.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果により、我々が解析したHxAlGltnは、瘢痕拘縮抑制に関して一定の効果を認めた。
手術術後の瘢痕拘縮の抑制が可能になれば、瘢痕による術後の口唇の変形の軽減や、上顎骨成長抑制の防止が期待され、歯科矯正や言語治療期間の短縮、二次手術の減少が見込めるため、国の医療費の削減につながり国民全体の利益となると考えられた。その意味で、その一端をになる見地を得られた本研究の意義は大きいと思われる。
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