Study of intractable pain in Sjogren's syndrome as a target for mechanically-gated ion channel Piezo2.
| Project/Area Number |
16K11766
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岩田 幸一 日本大学, 歯学部, 教授 (60160115)
今村 佳樹 日本大学, 歯学部, 教授 (90176503)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | シェーグレン症候群 / 口腔乾燥 / 舌痛 / Piezo2チャネル / 三叉神経節 / ATP / P2X2/3受容体 / Piezo2 / TRPV4 / P2X2/3R / 難治性疼痛 |
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| Outline of Final Research Achievements |
Thymectomy on day 3 after birth was performed in male NFS/sld mice to produce Sjogren’s syndrome (SS) model. SS is an autoimmune disease affecting the lacrimal and salivary glands and show severe dry mouth and burning pain in the mouth. We aimed to investigate the mechanism of tongue pain induced by dry mouth. In the result, tongue tissue was injured by severe dry mouth that was induced by decrease of salivary secretion in SS model. ATP might be leaked out from injured tissue and stimulate Piezo2 channel and P2X2/3 receptor. Besides, TRPV4 might be also involved in the mechanism of tongue pain induced by dry mouth. It is hoped that more research will be conducted in relation of mechanosensitive channel and tongue hyperalgesia induced by dry mouth in Sjogren’s syndrome.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では，強い口腔乾燥が舌組織を傷害し，機械受容チャネルであるPiezo2やP2X2/3受容体などが刺激され，舌の痛覚過敏を引き起こす可能性を示した。この結果は，これまで解明できなかった，シェーグレン症候群を含む口腔乾燥による難治性の舌痛に苦しんでいる患者に奏功する鎮痛剤の開発につながる可能性がある。
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives.2019
Author(s)
Imamura Y, Shinozaki T, Okada-Ogawa A, Noma N, Shinoda M, Iwata K, Wada A, Abe O, Wang K, Svensson P.
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Journal Title
J Oral Rehabil.
Volume: -
Issue: 6
Pages: 574-587
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Headache attributed to temporomandibular disorders and masticatory myofascial pain2016
Author(s)
Hara K, Shinozaki T, Okada-Ogawa A, Matsukawa Y, Dezawa K, Nakaya Y, Chen JY, Noma N, Oka S, Iwata K, Imamura Y.
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Journal Title
Journal of Oral Science
Volume: 58
Issue: 2
Pages: 195-204
DOI
NAID
ISSN
1343-4934, 1880-4926
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] ERK-GluR1 phosphorylation in trigeminal spinal subnucleus caudalis neurons is involved in pain associated with dry tongue2016
Author(s)
Nakaya Y, Tsuboi Y, Okada-Ogawa A, Shinoda M, Kubo A, Chen JY, Noma N, Batbold D, Imamura Y, Sessle BJ, Iwata K
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Journal Title
Molecular Pain
Volume: -
Pages: 12-12
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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