Bioglass/Chitosan/Silver nanoparticle synthesis and their application to bioactive surface modification

• Project/Area Number: 16K11794
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: IIJIMA MASAHIRO 北海道医療大学, 歯学部, 教授 (20305915)
• Co-Investigator(Kenkyū-buntansha): 六車 武史 北海道医療大学, 歯学部, 講師 (20343436)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: バイオアクティブガラス / 再石灰化 / 表面改質 / エレクトロディポジショニング / 機械的特性 / キトサン / エナメル質再石灰化 / ナノ粒子 / 矯正材料

Outline of Final Research Achievements

This study investigated the surface modification of orthodontic stainless steel using electrophoretic deposition (EPD) of bioactive glass (BG). The EPD process using alternating current produced higher values in both reflectance and lightness. Additionally, the BG coating was thinner than that prepared using direct current, and was completely amorphous. All of the BG coatings displayed good interfacial adhesion, and Si and O were the major components. The hardness and elastic modulus of etched enamel specimens immersed with most BG-coated specimens recovered significantly with increasing immersion time compared with the non-coated specimen. The surface modification technique using EPD and BG coating on orthodontic stainless steel may assist the development of new non-cytotoxic orthodontic metallic appliances having satisfactory appearance and remineralization ability.

Academic Significance and Societal Importance of the Research Achievements

固定式の装置を使用した矯正治療では、低い審美性やう蝕の誘発という問題がある。本研究では、高い生体活性を有するバイオガラスを利用した金属材料の表面改質が、歯の再石灰化能とう蝕抑制機能を有する審美性矯正用材料に応用可能であることを明らかとした。

Research Products

• [Journal Article] Effects of Addition of Strontium-Containing Bioactive Glass to 4-META/MMA-TBB-Based Resin on Remineralization of Etched Enamel (2018)
  • Author(s): Masahiro Iijima, Kyotaro Kawaguchi, Masahiro Kawaguchi, Naohiko Kawamura, Itaru Mizoguchi
  • Journal Title: Journal of Biomaterials and Tissue Engineering Volume: 8 Issue: 4 Pages: 537-544
  • DOI: 10.1166/jbt.2018.1772
  • Peer Reviewed
• [Journal Article] Electrophoretic Deposition as A New Bioactive Glass Coating Process for Orthodontic Stainless Steel (2017)
  • Author(s): Kyotaro Kawaguchi, Masahiro Iijima, Kazuhiko Endo, Itaru Mizoguchi
  • Journal Title: coatings Volume: 7, 199 Issue: 11 Pages: 199-199
  • DOI: 10.3390/coatings7110199
  • Peer Reviewed / Open Access
• [Presentation] New bioactive glass coating process for orthodontic stainless steel (2018)
  • Author(s): Iijima M, Kawaguchi K, Endo K, Mizoguchi I
  • Organizer: Annual Meeting of the AADR
  • Int'l Joint Research
• [Presentation] Characterization of Bioactive Glass Coating Formed on Stainless Steel Orthodontic Wire (2018)
  • Author(s): Iijima M, Kawaguchi K, Endo K, Mizoguchi I
  • Organizer: Annual Meeting of the EOS
  • Int'l Joint Research
• [Presentation] New bioactive glass coating process for orthodontic stainless steel (2018)
  • Author(s): Masahiro Iijima, Kyotaro Kawaguchi, Kazuhiko Endo, Itaru Mizoguchi
  • Organizer: 47th Annual Meeting of the AADR
  • Int'l Joint Research
• [Presentation] バイオアクティブガラスとEPD法用いた矯正用ワイヤーの審美性表面改質 (2017)
  • Author(s): 河口馨太朗，飯嶋雅弘，遠藤一彦，六車武史，川村尚彦，石川里奈，溝口 到
  • Organizer: 第76回日本矯正歯科学会学術大会
• [Presentation] バイオアクティブガラスを添加した4-META/MMA-TBBレジン接着材料のエナメル質再石灰化能 (2016)
  • Author(s): 河口 馨太朗、飯嶋 雅弘、川村 尚彦、六車 武史、溝口 到
  • Organizer: 第75回日本矯正歯科学会大会
  • Place of Presentation: アスティーとくしま
  • Year and Date: 2016-11-08