• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The relationship between the stress response and central nervous system in the the adult rat experienced immobilization stress in the early postnatal period

Research Project

Project/Area Number 16K11799
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionHokkaido University

Principal Investigator

YOSHIHARA TOSHIHIRO  北海道大学, 歯学研究院, 准教授 (60261319)

Co-Investigator(Kenkyū-buntansha) 大島 昇平  北海道大学, 大学病院, 講師 (00374546)
菊入 崇  北海道大学, 歯学研究院, 助教 (10322819)
高崎 千尋  北海道大学, 歯学研究院, 助教 (60451449)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords身体抑制 / 中枢神経系 / ラット / HPA axis / 視床下部 / 視床下部下垂体副腎皮質系 / 大脳辺縁系
Outline of Final Research Achievements

Twenty-four male pups were divided into 4 groups: A (the rats was subjected to immobilization stress for 30 min per day from P7 to P13), B (the rats was subjected to immobilization stress for 30 min per day from P21 to P27),C (the rats was subjected to immobilization stress for 30 min per day from P35 to P41), and D (the unmanipulated control group ). A group indicated higher stress responsivity to the novel stress and increased evpressions of glucocoricoid reseptor in the amygdala, hippocampus, and hypothalamus compared with other 3 groups.

Academic Significance and Societal Importance of the Research Achievements

本研究成果より、身体抑制が成長後の中枢神経系機能に影響することが示され、身体抑制具を用いる上での問題点のエビデンスとなり、小児歯科学・障害者歯科学の発展に大きく寄与するものである。また、中枢神経系機能への影響を緩和する方策の道筋についても、本研究より示されたので、今後、身体抑制のよる人体への影響を和らげる研究が発展することが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Daily life habits associated with eveningness lead to a higher prevalence of dental caries in children2019

    • Author(s)
      Shinya Nishide, Toshihiro Yoshihara, Hirohisa Hongo, Takashi Kanehira, Yasutaka Yawaka
    • Journal Title

      Journal of Dental Sciences

      Volume: 印刷中 Issue: 3 Pages: 302-308

    • DOI

      10.1016/j.jds.2019.01.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral findings in a patient with megacystis microcolon intestinal hypoperistalsis2018

    • Author(s)
      Chihiro Takasaki, Toshihiro Yoshihara, Yasutaka Yawaka
    • Journal Title

      Pediatric Dental Journal

      Volume: 28(2) Issue: 2 Pages: 57-61

    • DOI

      10.1016/j.pdj.2018.05.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi