The relationship between the stress response and central nervous system in the the adult rat experienced immobilization stress in the early postnatal period
| Project/Area Number |
16K11799
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大島 昇平 北海道大学, 大学病院, 講師 (00374546)
菊入 崇 北海道大学, 歯学研究院, 助教 (10322819)
高崎 千尋 北海道大学, 歯学研究院, 助教 (60451449)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 身体抑制 / 中枢神経系 / ラット / HPA axis / 視床下部 / 視床下部下垂体副腎皮質系 / 大脳辺縁系 |
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| Outline of Final Research Achievements |
Twenty-four male pups were divided into 4 groups: A (the rats was subjected to immobilization stress for 30 min per day from P7 to P13), B (the rats was subjected to immobilization stress for 30 min per day from P21 to P27),C (the rats was subjected to immobilization stress for 30 min per day from P35 to P41), and D (the unmanipulated control group ). A group indicated higher stress responsivity to the novel stress and increased evpressions of glucocoricoid reseptor in the amygdala, hippocampus, and hypothalamus compared with other 3 groups.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果より、身体抑制が成長後の中枢神経系機能に影響することが示され、身体抑制具を用いる上での問題点のエビデンスとなり、小児歯科学・障害者歯科学の発展に大きく寄与するものである。また、中枢神経系機能への影響を緩和する方策の道筋についても、本研究より示されたので、今後、身体抑制のよる人体への影響を和らげる研究が発展することが期待される。
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Report
(4 results)
Research Products
(2 results)
