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Fabrication and application of nanomaterial using biomineralization method for periodontal tissue engineering

Research Project

Project/Area Number 16K11822
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontology
Research InstitutionHokkaido University

Principal Investigator

Miyaji Hirofumi  北海道大学, 大学病院, 講師 (50372256)

Co-Investigator(Kenkyū-buntansha) 田中 佐織  北海道大学, 大学病院, 講師 (90344522)
加藤 昭人  北海道大学, 歯学研究院, 助教 (40507571)
中塚 愛  北海道大学, 大学病院, 助教 (00547648)
西田 絵利香  北海道大学, 大学病院, 医員 (50779882)
Research Collaborator OYANE Ayako  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsバイオミネラリゼーション / アパタイト / スキャフォールド / 生体親和性 / 骨増生 / 歯周組織再生 / ナノ構造 / 線維芽細胞増殖因子 / スキャフォールド(足場材) / バイオミメティック法 / リン酸カルシウム / 線維芽細胞増殖因子(FGF2) / リアルタイムPCR / 骨芽細胞分化マーカー / 骨形成 / ラット / コラーゲン / 再生医学 / 歯学 / 生体材料 / ナノ材料 / 細胞・組織
Outline of Final Research Achievements

We fabricated the nano-structured apatite scaffold using biomineralization method to imitate the bone formation in the body. The evaluation of biocompatibility, bone inductive effect and periodontal regenerative activity of apatite scaffold were carried out. In addition, we obtained the apatite scaffold loaded with fibroblast growth factor-2 (FGF2) to enhance the bio-properties of scaffold and assessed the bone forming ability.
The results showed that apatite scaffold exhibited high biocompatibility and bone forming effect in rat cranial bone defect. Apatite scaffold stimulated the periodontal regeneration in class II furcation defect in beagle dogs. In addition, FGF-2 loaded apatite scaffold remarkably promoted the bone augmentation of rat skull bone, compared to pristine apatite scaffold. The nano-structured apatite scaffold would be beneficial for medical application in bone and periodontal tissue engineering.

Academic Significance and Societal Importance of the Research Achievements

歯周病は国民病の一つで,患者数は国内で4500万人と推定され,超高齢社会を迎えますます増加の一途をたどっている.本研究ではバイオミネラリゼーション技術の応用によって骨や歯周組織を再生する効果が示されたことから,歯周病の新しい治療法として患者に貢献できる可能性がある.また生理活性物質FGF2の複合化によって再生量が飛躍的に増大することが実証され,複合物質を調整することで再生組織の選択性や抗菌性等も発揮できる可能性があり,再生医療イノベーションの一端を担う可能性がある.本研究での知見が医工連携でのナノ技術を用いた医療用マテリアルの開発促進につながることが期待される.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (80 results)

All 2019 2018 2017 2016 Other

All Journal Article (27 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 26 results,  Open Access: 22 results,  Acknowledgement Compliant: 5 results) Presentation (49 results) (of which Int'l Joint Research: 10 results,  Invited: 2 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Characterization and evaluation of graphene oxide scaffold for periodontal wound healing of class II furcation defects in dog2018

    • Author(s)
      Kohei Kawamoto, Hirofumi Miyaji, Erika Nishida, Saori Miyata, Akihito Kato, Akito Tateyama, Tomokazu Furihata, Kanako Shitomi, Toshihiko Iwanaga, Tsutomu Sugaya
    • Journal Title

      International Journal of Nanomedicine

      Volume: 13 Pages: 2365-2376

    • DOI

      10.2147/ijn.s163206

    • NAID

      120006459320

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preparation of micro/nanopatterned gelatins crosslinked with genipin for biocompatible dental implants2018

    • Author(s)
      Makita Reika、Akasaka Tsukasa、Tamagawa Seiichi、Yoshida Yasuhiro、Miyata Saori、Miyaji Hirofumi、Sugaya Tsutomu
    • Journal Title

      Beilstein Journal of Nanotechnology

      Volume: 9 Pages: 1735-1754

    • DOI

      10.3762/bjnano.9.165

    • NAID

      120006489814

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aggregation/Self-Assembly-Induced Approach for Efficient AuAg Bimetallic Nanocluster-Based Photosensitizers2018

    • Author(s)
      Hikosou Daiki、Saita Sastoshi、Miyata Saori、Miyaji Hirofumi、Furuike Tetsuya、Tamura Hiroshi、Kawasaki Hideya
    • Journal Title

      The Journal of Physical Chemistry C

      Volume: 122 Issue: 23 Pages: 12494-12501

    • DOI

      10.1021/acs.jpcc.8b02373

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibacterial Photocurable Acrylic Resin Coating Using a Conjugate between Silver Nanoclusters and Alkyl Quaternary Ammonium2018

    • Author(s)
      Tominaga Chiaki、Shitomi Kanako、Miyaji Hirofumi、Kawasaki Hideya
    • Journal Title

      ACS Applied Nano Materials

      Volume: 1 Issue: 9 Pages: 4809-4818

    • DOI

      10.1021/acsanm.8b01010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium phosphate coating on dental composite resins by a laser-assisted biomimetic process2018

    • Author(s)
      ARPUTHARAJ Nathanael Joseph、大矢根 綾子、中村 真紀、古賀 健司、西田 絵利香、田中 佐織、宮治 裕史
    • Journal Title

      Heliyon

      Volume: 4 Issue: 8 Pages: e00734-e00734

    • DOI

      10.1016/j.heliyon.2018.e00734

    • NAID

      120006531997

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laser-assisted wet coating of calcium phosphate for surface-functionalization of PEEK2018

    • Author(s)
      大矢根 綾子、中村 真紀、坂巻 育子、清水 禎樹、宮田 さほり、宮治 裕史
    • Journal Title

      PLoS One

      Volume: 13 Issue: 10 Pages: e0206524-e0206524

    • DOI

      10.1371/journal.pone.0206524

    • NAID

      120006543301

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bovine serum albumin-capped gold nanoclusters conjugating with methylene blue for efficient 1O2 generation via energy transfer.2018

    • Author(s)
      M Yamamoto, K Shitomi, S Miyata, H Miyaji, H Aota, H Kawasaki.
    • Journal Title

      J Colloid Interface Sci

      Volume: 510 Pages: 221-227

    • DOI

      10.1016/j.jcis.2017.09.011

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Near-infrared irradiation and graphene oxide film fabricated on dentin surface exhibit photothermal and antibacterial effects.2018

    • Author(s)
      K Nagao, H Miyaji, E Nishida, T Akasaka, S Miyata, K Shitomi, K Mayumi, A Kato, T Sugaya.
    • Journal Title

      J Oral Hyg Health

      Volume: 6 Issue: 01 Pages: 1-6

    • DOI

      10.4172/2332-0702.1000231

    • NAID

      120006410544

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of tissue behavior on three-dimensional collagen scaffold coated with carbon nanotubes and β-tricalcium phosphate nanoparticles.2018

    • Author(s)
      H Miyaji, S Murakami, E Nishida, T Akasaka, B Fugetsu, J Umeda, K Kondoh, T Iizuka, T Sugaya.
    • Journal Title

      J Oral Tissue Engin

      Volume: 15 Pages: 123-130

    • NAID

      130006730878

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antimicrobial photodynamic activity and cytocompatibility of Au25(Capt)18 clusters photoexcited by blue LED light irradiation2017

    • Author(s)
      S Miyata, H Miyaji, H Kawasaki, M Yamamoto, E Nishida, H Takita, T Akasaka, N Ushijima, T Iwanaga, T Sugaya
    • Journal Title

      Int J Nanomed

      Volume: 12 Pages: 2703-2716

    • DOI

      10.2147/ijn.s131602

    • NAID

      120006024358

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Submicro-patterning of curable dental materials by molding methods: a screening trial.2017

    • Author(s)
      T Akasaka, H Miyaji, T Imamura, N Kaga, A Yokoyama, Y Yoshida.
    • Journal Title

      Dig J Nanomater Bios

      Volume: 12 Pages: 281-292

    • NAID

      120006024408

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro and in vivo analysis of mineralized collagen-based sponges prepared by a plasma- and precursor-assisted biomimetic process.2017

    • Author(s)
      AJ Nathanael, A Oyane, M Nakamura, I Sakamaki, E Nishida, Y Kanemoto, H Miyaji.
    • Journal Title

      ACS Appl Mater Interfaces

      Volume: 9 Issue: 27 Pages: 22185-22194

    • DOI

      10.1021/acsami.7b04776

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds2017

    • Author(s)
      S Murakami, H Miyaji, E Nishida, K Kawamoto, S Miyata, H Takita, T Akasaka, B Fugetsu, T Iwanaga, H Hongo, N Amizuka, T Sugaya, M Kawanami.
    • Journal Title

      Dental Materials Journal

      Volume: 36 Issue: 5 Pages: 573-583

    • DOI

      10.4012/dmj.2016-295

    • NAID

      130006100273

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antibacterial and cytotoxic effects of photoexcited Au clusters via blue high-power or white low-power light-emitting diode irradiation2017

    • Author(s)
      S Miyata, H Miyaji, H Kawasaki, E Nishida, K Shitomi, T Akasaka, S Tanaka, T Iizuka, T Sugaya
    • Journal Title

      Biology, Engineering and Medicine

      Volume: 2 Issue: 4 Pages: 1-4

    • DOI

      10.15761/bem.1000126

    • NAID

      120006366521

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin2017

    • Author(s)
      A Tateyama, A Kato, H Miyaji, E Nishida, Y Iwasaki, S Fujii, K Kawamoto, K Shitomi, T Furihata, K Mayumi, T Sugaya.
    • Journal Title

      Nano Biomedicine

      Volume: 9 Issue: 2 Pages: 69-76

    • DOI

      10.11344/nano.9.69

    • NAID

      130006415678

    • ISSN
      1883-5198, 2185-4734
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds2017

    • Author(s)
      S Murakami, H Miyaji, E Nishida, K Kawamoto, S Miyata, H Takita, T Akasaka, B Fugetsu, T Iwanaga, H Hongo, N Amizuka, T Sugaya, M Kawanami
    • Journal Title

      Dent Mater J

      Volume: 印刷中

    • NAID

      130006100273

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Submicro-patterning of curable dental materials by molding methods: a screening trial2017

    • Author(s)
      T Akasaka, H Miyaji, T Imamura, N Kaga, A Yokoyama, Y Yoshida
    • Journal Title

      Dig J Nanomater Bios

      Volume: 12 Pages: 281-292

    • NAID

      120006024408

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of graphene oxide nanosheets for periodontal treatment2016

    • Author(s)
      宮治裕史,西田絵利香
    • Journal Title

      Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)

      Volume: 58 Issue: 2 Pages: 65-71

    • DOI

      10.2329/perio.58.65

    • NAID

      130005164865

    • ISSN
      0385-0110, 1880-408X
    • Related Report
      2016 Research-status Report
  • [Journal Article] Graphene oxide scaffold accelerates cellular proliferative response and alveolar bone healing of tooth extraction socket2016

    • Author(s)
      E Nishida, H Miyaji, A Kato, H Takita, T Iwanaga, T Momose, K Ogawa, S Murakami, T Sugaya, M Kawanami
    • Journal Title

      Int J Nanomed

      Volume: 11 Pages: 2265-2277

    • DOI

      10.2147/ijn.s104778

    • NAID

      120005906795

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Collagen hydrogel scaffold and fibroblast growth factor-2 accelerate periodontal healing of class II furcation defects in dog2016

    • Author(s)
      T Momose, H Miyaji, A Kato, K Ogawa, T Yoshida, E Nishida, S Murakami, Y Kosen, T Sugaya, M Kawanami
    • Journal Title

      The Open Dentistry Journal

      Volume: 10 Issue: 1 Pages: 347-359

    • DOI

      10.2174/1874210601610010347

    • NAID

      120005825583

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bone-forming Effects of Collagen Scaffold Containing β-tricalcium Phosphate Nanoparticles on Extraction Sockets in Dogs2016

    • Author(s)
      加藤昭人,宮治裕史,小川幸佑,百瀬赳人,西田絵利香,村上秀輔,吉田 崇,田中佐織,菅谷 勉,川浪雅光
    • Journal Title

      The Japanese Journal of Conservative Dentistry

      Volume: 59 Issue: 4 Pages: 351-358

    • DOI

      10.11471/shikahozon.59.351

    • NAID

      130005263738

    • ISSN
      0387-2343, 2188-0808
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Semaphorin 3A Induces Odontoblastic Phenotype in Dental Pulp Stem Cells.2016

    • Author(s)
      Yoshida S, Wada N, Hasegawa D, Miyaji H, Mitarai H, Tomokiyo A, Hamano S, Maeda H.
    • Journal Title

      Journal of Dental Research

      Volume: 95 Issue: 11 Pages: 1282-1290

    • DOI

      10.1177/0022034516653085

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Modification of composite resin surface with carbon nanotubes enhances cell proliferation2016

    • Author(s)
      S Tanaka, H Miyaji, E Nishida, K Inoue, S Miyata, A Kato, I Kanayama, S Murakami, K Kawamoto, B Fugetsu, T Tanaka, H Takita, T Iizuka, M Kawanami
    • Journal Title

      Nano Biomedicine

      Volume: 8 Pages: 27-34

    • NAID

      130005249733

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physicochemical fabrication of antibacterial calcium phosphate submicrospheres with dispersed silver nanoparticles via coprecipitation and photoreduction under laser irradiation2016

    • Author(s)
      M Nakamura, A Oyane, Y Shimizu, S Miyata, A Saeki, H Miyaji.
    • Journal Title

      Acta Biomater

      Volume: 46 Pages: 299-307

    • DOI

      10.1016/j.actbio.2016.09.015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Periodontal tissue engineering by nano beta-tricalcium phosphate scaffold and fibroblast growth factor-2 in one-wall infrabony defects of dogs2016

    • Author(s)
      K Ogawa, H Miyaji, A Kato, Y Kosen, T Momose, T Yoshida, E Nishida, S Miyata, S Murakami, H Takita, B Fugetsu, T Sugaya, M Kawanami
    • Journal Title

      J Periodont Res

      Volume: 51 Issue: 6 Pages: 758-767

    • DOI

      10.1111/jre.12352

    • NAID

      120006377558

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effect of Protein Adsorption on Alignment of Human Gingival Fibroblasts on Grooved Composite Resin2016

    • Author(s)
      T Akasaka, T Imamura, H Miyaji, N Kaga, A Yokoyama, Y Yoshida
    • Journal Title

      e-Journal of Surface Science and Nanotechnology

      Volume: 14 Issue: 0 Pages: 225-230

    • DOI

      10.1380/ejssnt.2016.225

    • NAID

      130005433502

    • ISSN
      1348-0391
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adhesion of Osteoblast-like Cells (Saos-2) on Micro-/Submicro-Patterned Apatite Scaffolds Fabricated with Apatite Cement Paste by Micro-Molding2016

    • Author(s)
      T Akasaka, H Miyaji, N Kaga, A Yokoyama, S Abe, Y Yoshida
    • Journal Title

      Nano Biomedicine

      Volume: 8 Issue: 2 Pages: 112-122

    • DOI

      10.11344/nano.8.112

    • NAID

      130005243593

    • ISSN
      1883-5198, 2185-4734
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 細胞接着因子担持アパタイト膜のレーザー転写による生理活性パターニング2019

    • Author(s)
      小室智稀,奈良崎愛子,黒崎諒三,亀山智子,大矢根綾子,海野昌喜,宮治裕史
    • Organizer
      レーザー学会学術講演会第39回年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Laser-induced forward transfer of bioactive apatite immobilizing proteins2019

    • Author(s)
      A Narazaki, R Kurosaki, T Kameyama, I Sakamaki, H Araki, A Oyane, H Miyaji
    • Organizer
      SPIE. Photonics WEST 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗菌性樹脂用途向けの銀ナノクラスター/第四級アンモニウムカチオン複合体の合成2019

    • Author(s)
      川崎英也,富永千明,蔀 佳奈子,宮治裕史
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ナノβ-TCP/ヒトⅠ型コラーゲン様リコンビナントペプチド顆粒の骨形成特性評価2019

    • Author(s)
      西田絵利香,宮治裕史,降籏友和,宮田さほり,加藤昭人,金本佑生実,菅谷 勉,赤坂 司
    • Organizer
      第18回日本再生医療学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 過飽和液中レーザー照射法を利用したヒト象牙質基材へのフッ素担持アパタイト成膜2019

    • Author(s)
      大矢根綾子,坂巻育子,中村真紀・古賀健司,蔀 佳奈子,眞弓佳代子,宮治裕史
    • Organizer
      日本セラミックス協会2019年年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] リゾチーム保護金クラスター・有機色素複合体の1O2生成能評価2018

    • Author(s)
      塩谷 聡,宮治裕史,川﨑英也
    • Organizer
      ナノ学会第16回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Apatite coating based on laser-induced forward transfer for dental treatment2018

    • Author(s)
      A Narazaki, R Kurosaki, I Sakamaki, A Oyane, H Miyaji
    • Organizer
      LPM2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Zinc-Fluorideガラス塗布材の細胞親和性評価2018

    • Author(s)
      西田絵利香,宮治裕史,蔀 佳奈子,菅谷 勉
    • Organizer
      第148回日本歯科保存学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 亜鉛ガラス含有グラスアイオノマーセメントの物性および抗菌効果2018

    • Author(s)
      蔀 佳奈子,宮治裕史,西田絵利香,菅谷 勉
    • Organizer
      第148回日本歯科保存学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] S-PRGフィラー含有根管充填シーラーによる根管充填後の根尖組織治癒2018

    • Author(s)
      宮治裕史,眞弓佳代子,金本佑生実,西田絵利香
    • Organizer
      第148回日本歯科保存学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Aggregation/self-assembly-induced approach for efficient AuAg bimetallic nanocluster-based photosensitizers2018

    • Author(s)
      D Hikoso, S Saita, S Miyata, H Miyaji, T Furuike, H Tamura, H Kawasaki
    • Organizer
      ISST2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 飽和液中レーザー照射による象牙質表面への迅速リン酸カルシウム成膜2018

    • Author(s)
      大矢根綾子,A. Joseph Nathanael,中村真紀,眞弓佳代子,蔀佳奈子,宮治裕史
    • Organizer
      日本セラミックス協会第31回秋季シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 金銀合金ナノクラスターで架橋されたキトサンナノゲルによる可視光応答型光増感剤2018

    • Author(s)
      彦惣大輝,斎田 慧,宮田さほり,宮治裕史,古池哲也,田村 裕,川﨑英也
    • Organizer
      第69回コロイドおよび界面化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生体に心地よい無機質表面の作り方と歯科応用2018

    • Author(s)
      大矢根綾子,AJ Nathanae,中村真紀 ,宮治裕史
    • Organizer
      第8回CSJ化学フェスタ2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Application of S-PRG nanofillers for novel periodontal therapeutic approach2018

    • Author(s)
      H Miyaji, K Mayumi, E Nishida, S Miyata, K Shitomi, T Furihata, Y Kanemoto, T Akasaka, T Sugaya
    • Organizer
      104th annual meeting of AAP
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acid-resistance and antibacterial properties of laser-processed and fluoride-incorporated apatite layer2018

    • Author(s)
      K Shitomi, H Miyaji, AJ Nathanael, M Nakamura, A Oyane, T Sugaya
    • Organizer
      104th annual meeting of AAP
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シンバスタチン添加α-TCP微粒子エマルション骨ペーストの特性評価および骨形成効果2018

    • Author(s)
      舘山彰人,加藤昭人,宮治裕史,西田絵利香,岩﨑泰彦,藤井秀司,川本康平,蔀 佳奈子,降籏友和,眞弓佳代子,菅谷 勉
    • Organizer
      第61回秋季日本歯周病学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Calcium phosphate coating on human dentin and composite resin surface by laser-assisted biomimetic process2018

    • Author(s)
      S Tanaka, H Miyaji, E Nishida, AJ Nathanael, M Nakamura, A Oyane, T Tanaka, S Inoue
    • Organizer
      20th KACD-JSCD Joint Scientific Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 過飽和液中レーザー照射法による象牙質表面へのフッ素担持アパタイトの迅速成膜2018

    • Author(s)
      大矢根綾子,坂巻育子,中村真紀,古賀健司,蔀 佳奈子,眞弓佳代子,宮治裕史
    • Organizer
      第40回日本バイオマテリアル学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酸化グラフェンスキャフォールドへの亜鉛担持による抗菌性の向上2018

    • Author(s)
      西田絵利香,宮治裕史,蔀 佳奈子,菅谷 勉,小野 博信
    • Organizer
      第40回日本バイオマテリアル学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Fluoride-incorporated apatite coating for tooth surface modification by laser irradiation in supersaturated solutions2018

    • Author(s)
      A Oyane, AJ Nathanael, M Nakamura, K Shitomi, H Miyaji
    • Organizer
      Bioceramics 30
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] カーボンナノチューブによるチタン-生体界面のナノスケール改質と骨形成接合効果2018

    • Author(s)
      西田絵利香,宮治裕史,蔀 佳奈子,眞弓佳代子,菅谷 勉,梅田純子,近藤勝義,古月文志
    • Organizer
      第16回日本再生歯科医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Laser-lift-off process for additive micropatterning of functional particles and films2018

    • Author(s)
      A Narazaki, T Sato, H Niino, Y Nakata, T Shojo, Y Tsuboi, A Oyane, H Miyaji
    • Organizer
      MHS2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 過飽和液中レーザー照射によるフッ素担持アパタイトの迅速成膜2018

    • Author(s)
      A. Joseph NATHANAEL,大矢根綾子,中村真紀,蔀 佳奈子,宮治裕史
    • Organizer
      日本セラミックス協会2018年年会
    • Related Report
      2017 Research-status Report
  • [Presentation] イオン徐放性S-PRGフィラーの粒子サイズが抗菌性及び細胞親和性に及ぼす効果2017

    • Author(s)
      眞弓佳代子,宮治裕史,宮田さほり,蔀 佳奈子,西田絵利香,金本佑生実,菅谷 勉
    • Organizer
      第60回春季日本歯周病学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2017-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] バイオミメティック法によるリン酸カルシウム成膜スキャフォールドの特性評価2017

    • Author(s)
      西田絵利香,宮治裕史,金本佑生実,A. Joseph NATHANAEL,中村真紀,大矢根綾子,村上秀輔,眞弓佳代子,加藤昭人,菅谷 勉
    • Organizer
      第16回日本再生医療学会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2017-03-07
    • Related Report
      2016 Research-status Report
  • [Presentation] イオン徐放性S-PRGフィラーの粒子サイズが抗菌性及び細胞親和性に及ぼす効果.2017

    • Author(s)
      眞弓佳代子,宮治裕史,宮田さほり,蔀 佳奈子,西田絵利香,金本佑生実,菅谷 勉
    • Organizer
      第60回春季日本歯周病学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 歯周治療に向けたAgクラスター/ローズベンガル複合体の特性評価2017

    • Author(s)
      蔀 佳奈子,宮治裕史,宮田さほり,菅谷 勉
    • Organizer
      第60回春季日本歯周病学会学術大会
    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Presentation] Apatite-coated collagen sponges for tissue engineering applications2017

    • Author(s)
      AJ Nathanael, A Oyane, M Nakamura, H Miyaji, E Nishida, Y Kanemoto
    • Organizer
      International Union of Materials Research Societies - The 15th International Conference on Advanced Materials (IUMRS-ICAM) 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] レーザー照射による焼結水酸アパタイト基材へのフッ素担持リン酸カルシウム成膜と抗菌特性評価2017

    • Author(s)
      蔀 佳奈子,宮治裕史,A. Joseph NATHANAEL,中村真紀, 大矢根綾子,菅谷 勉.
    • Organizer
      日本歯科保存学会2017年度秋季学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Zinc-Fluorideガラス塗布材のイオン徐放性と抗菌効果2017

    • Author(s)
      西田絵利香,宮治裕史,蔀 佳奈子,菅谷 勉
    • Organizer
      日本歯科保存学会2017年度秋季学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] レーザー援用バイオミメティック法によるレジン表面の改変とアパタイト形成能評価2017

    • Author(s)
      田中佐織,宮治裕史,西田絵利香,A. Joseph NATHANAEL,中村真紀,大矢根綾子,田中 享,飯田俊二,高師則行,井上 哲
    • Organizer
      第10回日本総合歯科学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] リゾチーム金ナノクラスター/ローズベンガル複合体の創製と光線力学的評価2017

    • Author(s)
      岡本一絵,宮治裕史,宮田さほり,蔀 佳奈子,川﨑英也,赤坂 司,菅谷 勉
    • Organizer
      第39回日本バイオマテリアル学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 過飽和液中レーザー照射によるフッ素担持リン酸カルシウム成膜と抗菌性評価2017

    • Author(s)
      A. Joseph NATHANAEL,大矢根綾子,中村真紀,蔀 佳奈子,宮治裕史
    • Organizer
      第39回日本バイオマテリアル学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Agクラスター/ローズベンガル複合体の創製と光励起による抗菌性の発現2016

    • Author(s)
      蔀 佳奈子, 宮治裕史, 宮田さほり, 佐伯 歩, 川崎英也, 長谷川裕美, 岩永敏彦, 菅谷 勉
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-11-21
    • Related Report
      2016 Research-status Report
  • [Presentation] バイオミメティック法によるリン酸カルシウム成膜スキャフォールドの生物学的特性2016

    • Author(s)
      金本佑生実,宮治裕史,西田絵利香,A. Joseph NATHANAEL,中村真紀,大矢根綾子,村上秀輔,眞弓佳代子,加藤昭人,菅谷 勉
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-11-21
    • Related Report
      2016 Research-status Report
  • [Presentation] ゲニピン添加マイクロ・ナノパターン化ゼラチン上での細胞接着2016

    • Author(s)
      蒔田玲果,赤坂 司,宮治裕史,宮田さほり,菅谷 勉
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-11-21
    • Related Report
      2016 Research-status Report
  • [Presentation] レーザー光を用いて作製した銀ナノ粒子含有リン酸カルシウム球状粒子の抗菌性評価2016

    • Author(s)
      中村真紀,大矢根綾子,宮田さほり,佐伯 歩,宮治裕史
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-11-21
    • Related Report
      2016 Research-status Report
  • [Presentation] 金クラスターを用いた抗菌的光線力学療法の開発 -歯周病原菌に対する抗菌効果と細胞親和性-2016

    • Author(s)
      宮田さほり,宮治裕史,佐伯 歩,川崎英也,田中佐織,菅谷 勉
    • Organizer
      日本歯科保存学会2016年度秋季学術大会
    • Place of Presentation
      キッセイ文化ホール(長野県・松本市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 酸化グラフェンと近赤外線光を用いた光熱的抗菌治療法の開発2016

    • Author(s)
      長尾敬志,宮治裕史,西田絵利香,加藤昭人,菅谷 勉
    • Organizer
      日本歯科保存学会2016年度秋季学術大会
    • Place of Presentation
      キッセイ文化ホール(長野県・松本市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] イオン徐放性S-PRGナノフィラーを用いた歯面の機能性コーティング2016

    • Author(s)
      眞弓佳代子,宮治裕史,宮田さほり,蔀 佳奈子,菅谷 勉
    • Organizer
      日本歯科保存学会2016年度秋季学術大会
    • Place of Presentation
      キッセイ文化ホール(長野県・松本市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] レーザー援用バイオミメティック法によるレジン表面へのリン酸カルシウムの析出2016

    • Author(s)
      西田絵利香,宮治裕史,A. Joseph NATHANAEL,中村真紀,大矢根綾子,田中佐織,田中 享,加藤昭人,菅谷 勉
    • Organizer
      日本歯科保存学会2016年度秋季学術大会
    • Place of Presentation
      キッセイ文化ホール(長野県・松本市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] ナノシールによる根面う蝕の進行抑制に関する研究2016

    • Author(s)
      宮治裕史,田中佐織,加藤昭人,井上加菜,西尾啓英,川浪雅光
    • Organizer
      第23回日本歯科医学会総会
    • Place of Presentation
      福岡国際会議場,福岡サンパレス(福岡県・福岡市)
    • Year and Date
      2016-10-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Biomedical Assessment of Titanium coated with Carbon Nanotubes2016

    • Author(s)
      H Miyaji, E Nishida, J Umeda, K Kondoh, H Takita, T Iizuka, T Akasaka, S Tanaka, A Kato, B Fugetsu, T Sugaya
    • Organizer
      Visual-JW 2016 Symposium
    • Place of Presentation
      ホテル阪急エキスポパーク (大阪府・吹田市)
    • Year and Date
      2016-10-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 酸化グラフェンスキャフォールド埋植による歯周組織治癒促進効果2016

    • Author(s)
      川本康平,宮治裕史,加藤昭人,西田絵利香,小川幸佑,舘山彰人,降旗友和,宮田さほり,蔀 佳奈子,菅谷 勉
    • Organizer
      第59回秋季日本歯周病学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県・新潟市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 液中レーザー溶融法を用いて合成した銀含有リン酸カルシウム球状ナノ粒子の抗菌性評価2016

    • Author(s)
      宮田さほり,宮治裕史,中村真紀,大矢根綾子,菅谷 勉
    • Organizer
      第59回秋季日本歯周病学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県・新潟市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 酸化グラフェンでコーティングされた歯根象牙質の抗菌性の評価2016

    • Author(s)
      長尾敬志,宮治裕史,西田絵利香,川浪雅光
    • Organizer
      第59回春季日本歯周病学会学術大会
    • Place of Presentation
      かごしま県民交流センター・宝山ホール(鹿児島県・鹿児島市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 酸化グラフェン配合スキャフォールドによる骨形成効果2016

    • Author(s)
      降旗友和,宮治裕史,西田絵利香,川本康平,小川幸佑,百瀬赳人,舘山彰人,長尾敬志,吉田 崇,加藤昭人,川浪雅光
    • Organizer
      第59回春季日本歯周病学会学術大会
    • Place of Presentation
      かごしま県民交流センター・宝山ホール(鹿児島県・鹿児島市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 金クラスターを用いた抗菌的光線力学療法の開発-LED光源の違いによる検討-2016

    • Author(s)
      宮田さほり,宮治裕史,蔀 佳奈子,川浪雅光
    • Organizer
      第59回春季日本歯周病学会学術大会
    • Place of Presentation
      かごしま県民交流センター・宝山ホール(鹿児島県・鹿児島市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
  • [Remarks] 北海道大学大学院歯学研究院歯周病再生治療研究班

    • URL

      https://www.den.hokudai.ac.jp/hozon2/biomate.html

    • Related Report
      2017 Research-status Report
  • [Remarks] 歯周病再生治療研究グループ

    • URL

      https://www.den.hokudai.ac.jp/hozon2/biomate.html

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] コラーゲン様ペプチド及びリン酸カルシウムの複合体並びにこれを含む生体組織修復材2018

    • Inventor(s)
      宮治裕史,西田絵利香,宮田さほり,降籏友和
    • Industrial Property Rights Holder
      宮治裕史,西田絵利香,宮田さほり,降籏友和
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-217792
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 歯周病治療組成物およびそれを含むキット2016

    • Inventor(s)
      宮治裕史,宮田さほり,眞弓佳代子,中塚稔之,高橋啓至,笠場秀人
    • Industrial Property Rights Holder
      宮治裕史,宮田さほり,眞弓佳代子,中塚稔之,高橋啓至,笠場秀人
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-154288
    • Filing Date
      2016-08-05
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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