| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study, we investigated the effect of scaling and root planning (SRP) with local application of BDNF/Hyaluronic acid(HMW-HA) complex on the changes in clinical parameters and histology of periodontal tissue in dogs with ligature-induced periodontitis. The BDNF/HMW-HA group showed significant improvement of clinical parameters compared to those of the other groups in dogs. Histological analysis on the BDNF/HMW-HA group indicated suppression of apical migration of epithelial tissue and milder infiltration of inflammatory cells than it was observed in the other three groups. Furthermore, new cementum and alveolar bone were regenerated and collagen fibers were inserted into them in the BDNF/HMW-HA group.
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