| Project/Area Number |
16K11846
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
Naruse Keiko 愛知学院大学, 歯学部, 准教授 (30387576)
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| Co-Investigator(Kenkyū-buntansha) |
中村 信久 愛知学院大学, 歯学部, 講師 (50619773)
三谷 章雄 愛知学院大学, 歯学部, 教授 (50329611)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯周治療学 / 代謝学 / 歯周病治療学 / 歯周病学 |
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| Outline of Final Research Achievements |
Glucose-dependent insulinotropic polypeptide (GIP) stimulates pancreatic β cells to secrete insulin secretion. Since the receptor of GIP located in whole body, there are many investigations about the extrapancreatic effects of GIP. To examine the effect of GIP on periodontitis, we induced experimental periodontitis in GIP receptor-knockout mice (GIPRKO) in this study. Periodontitis in GIPRKO showed a marked increase of inflammatory cells in the gingivomucosal tissue. The infiltrated inflammatory cells expressed GIPR, suggesting that GIP ameliorates periodontitis via GIPR of inflammatory cells. These results suggest the therapeutic potency of GIP on periodontal disease.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究結果はGIPがその受容体を介して歯周病の発症・進展を抑制することを示唆しており、GIP関連薬は歯周病の新しい治療戦略となり得る。さらに現在我が国の糖尿病患者に最も多く使用されているDPP-4阻害薬は、GIPの作用も増強することから、DPP-4阻害薬を含めたGIP関連薬は、血糖降下作用とともに歯周炎に対する抗炎症作用を持つ糖尿病合併歯周炎の新しい治療戦略としても期待できる。
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