| Project/Area Number |
16K11856
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Asahi University (2018)
Okayama University (2016-2017) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森田 学 岡山大学, 医歯薬学総合研究科, 教授 (40157904)
米田 俊樹 岡山大学, 医歯薬学総合研究科, 助教 (60756071)
江國 大輔 岡山大学, 医歯薬学総合研究科, 准教授 (70346443)
友藤 孝明 朝日大学, 歯学部, 教授 (80335629)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 抗加齢 / 酸化ストレス / コーヒー / ラット |
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| Outline of Final Research Achievements |
Rats are divided into 4 groups: baseline group, control group (normal breeding), group A (0.62% coffee powder-containing diet intake group) and B group (1.36% coffee powder-containing diet intake group), and their anti-aging effect investigated. The degree of oxidative stress in the control group serum was significantly higher than that at baseline. The degree of serum antioxidants was significantly higher in Group B alone compared to baseline. As for the distance from the cement-enamel junction to the alveolar bone crest, the values in the control group showed significantly higher values than at the baseline, and the values in group B were significantly smaller compared to the control group.
The intake of a 1.36% coffee powder-containing diet increased serum antioxidant levels, reduced the increase in serum oxidative stress with aging, and reduced the degenerative changes of alveolar bone.
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| Academic Significance and Societal Importance of the Research Achievements |
コーヒー粉末配合食の摂取は、血清の抗酸化度を増加させ、加齢による血清や歯周組織の酸化ストレスの増加を低減し、歯槽骨の退行性変化を抑えた。急速な高齢化が進んでいる我が国では、高齢者の人達の肉体的・精神的健康を維持し、個人としても社会においても生産的な老後を送ること（productive aging）を可能にすることが、喫緊の課題である。口腔の抗加齢を目的とした本研究は、productive agingな社会を形成するために必須であり、そこに本研究の意義がある。
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