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Development of Supplement having anti-cancer action based on Flavonoid

Research Project

Project/Area Number 16K11863
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionOkayama University (2017-2018)
Nagasaki University (2016)

Principal Investigator

OKAMOTO Kuniaki  岡山大学, 医歯薬学総合研究科, 教授 (10311846)

Co-Investigator(Kenkyū-buntansha) 坂井 詠子  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10176612)
西下 一久  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (20237697)
筑波 隆幸  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30264055)
十川 千春  岡山大学, 医歯薬学総合研究科, 准教授 (10253022)
江口 傑徳  岡山大学, 医歯薬学総合研究科, 助教 (20457229)
奥舎 有加  岡山大学, 医歯薬学総合研究科, 助教 (50762027)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsフラボノイド / がん / 骨疾患 / 破骨細胞 / 口腔扁平上皮癌 / 予防 / 歯学 / 薬理学 / 細胞
Outline of Final Research Achievements

Lots of researchers reported that some flavonoids have an anti-cancer effect in vitro. But any effects of osteoclast and osteoblast correlated bone invasion and metastasis of cancer cells remain to investigate. In this research, we classified flavonoid into six gropes from its structure and analyzed the effect of each flavonoid in osteoclastogesesis. In result, Liquiritigenin, a component obtained from a Chinese herb, showed a significant inhibition effect during osteoclastogenesis. On the other hand, it did not inhibit osteoblast formation. Liquiritigenin is an aglycone of liquiritin, and it is one of the flavonoids present in Glycyrrhizae radix known as one of Kampo drug. Liquiritigenin has been shown to have various pharmacological effects, such as antioxidative, antitumor, and anti-inflammatory effects. Our data suggest that liquiritigenin may act as an inhibited supplement of osteoclasts in bone diseases such as osteoporosis.

Academic Significance and Societal Importance of the Research Achievements

漢方薬の甘草に含まれるリクイリチゲニンは破骨細胞抑制効果を持ち、骨芽細胞への抑制はない薬物であることが明らかとされた。破骨細胞形成を抑制した濃度は、構造の異なるフラボノイド、フィセチンと比較するとやや高い濃度であったが、骨芽細胞の形成を促進した初めてのフラボノイドであった。少しだけ構造のことなるフラボノイドにおいて、破骨細胞抑制効果がかなり違うことが明らかにされたことは、サプリメント開発において有意義なものであると考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2019 2018

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] KBTBD11, a novel BTB-Kelch protein, is a negative regulator of osteoclastogenesis through controlling Cullin3-mediated ubiquitination of NFATc1.2019

    • Author(s)
      Narahara S, Sakai E, Kadowaki T, Yamaguchi Y, Narahara H, Okamoto K, Asahina I, Tsukuba T.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 3523-3523

    • DOI

      10.1038/s41598-019-40240-2

    • NAID

      120006987780

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] <b>Dihydroartemisinin represses osteoclastogenesis of bone marrow macrophages through reduced NFATc1 expression and impaired phosphorylation of </b><b>IκBα </b>2018

    • Author(s)
      Komaki S, Sakai E, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T.
    • Journal Title

      Biomedical Research

      Volume: 39 Issue: 4 Pages: 169-177

    • DOI

      10.2220/biomedres.39.169

    • NAID

      130007432891

    • ISSN
      0388-6107, 1880-313X
    • Year and Date
      2018-08-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carcinogenic epithelial-mesenchymal transition initiated by oral cancer exosomes is inhibited by anti-EGFR antibody cetuximab.2018

    • Author(s)
      Fujiwara T, Eguchi T, Sogawa C, Ono K, Murakami J, Ibaragi S, Asaumi J, Calderwood SK, Okamoto K, Kozaki K.
    • Journal Title

      Oral Oncology

      Volume: 86 Pages: 251-257

    • DOI

      10.1016/j.oraloncology.2018.09.030

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Depletion of lipid efflux pump ABCG1 triggers the intracellular accumulation of extracellular vesicles and reduces aggregation and tumorigenesis of metastatic cancer cells.2018

    • Author(s)
      Namba Y, Sogawa C, Okusha Y, Kawai H, Itagaki M, Ono K, Murakami J, Aoyama E, Ohyama K, Asaumi J, Takigawa M, Okamoto K, Calderwood SK, Kozaki K, Eguchi T.
    • Journal Title

      Frontiers in Oncology

      Volume: 8(376) Pages: 1-16

    • DOI

      10.3389/fonc.2018.00376

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] EGFR標的抗体薬セツキシマブによる口腔癌由来のEGFR陽性エクソソームの制御2018

    • Author(s)
      藤原敏史、他
    • Organizer
      第30回口腔科学会近畿部会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Matrix metalloproteinase 3 regulates expression of Hsp gene in high-metastatic cell line of colon cancer2018

    • Author(s)
      Yuka Okusha, et al.
    • Organizer
      第91回日本薬理学会・第18回国際薬理学・臨床薬理学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of high metastatic evolved clone of adenocarcinoma cells with Mmp9 promoter-driven fluorescence reporter2018

    • Author(s)
      Chiharu Sogawa, et al.
    • Organizer
      第91回日本薬理学会・第18回国際薬理学・臨床薬理学会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 破骨細胞分化を負に制御するRabタンパク質の同定2018

    • Author(s)
      奥舎有加、他
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 口腔扁平上皮癌診断・治療における分子シャペロンHSP90含有細胞外小胞の可能性2018

    • Author(s)
      小野喜章、他
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 急速転移性癌細胞株由来細胞外小胞による破骨細胞分化および癌細胞浸潤の制御2018

    • Author(s)
      板垣まみ、他
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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