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Relationship between non-alcoholic fatty liver disease and periodontal disease and efficacy of periodontal treatment for nonalcoholic fatty liver disease

Research Project

Project/Area Number 16K11872
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

minabe masato  神奈川歯科大学, 大学院歯学研究科, 教授 (60148004)

Co-Investigator(Kenkyū-buntansha) 工藤 値英子  神奈川歯科大学, 大学院歯学研究科, 講師 (00397887)
中島 淳  横浜市立大学, 医学研究科, 教授 (30326037)
Research Collaborator Kamata Yohei  神奈川歯科大学, 大学院歯学研究科, 助教 (80385070)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsNAFLD / Porphyromonas gingivalis / periodontal treatment / lipopolysaccharides / alanine aminotransferase / immunoglobulin G / 非アルコール性脂肪性肝疾患 / 歯周病 / Porphyromonas Gingivitis
Outline of Final Research Achievements

Research results indicate that blood function tests show elevated liver function markers and the presence of endotoxin, which is the outer membrane component of Gram-negative bacilli, in saliva-porphyromonas gingivalis(p.g) positive patients. In addition, patients with liver stiffness of salivary p.g positive show high level of liver stiffness in MRE and fibroscan. In liver fibrosis patients, liver function markers are elevated and endotoxin is high. Regarding serum antibody titers of periodontitis bacteria in liver fibrotic patients, serum antibody titers such as p.g bacteria show high values. These show the relationship between NAFLD and periodontitis in blood, biochemistry, image analysis in medicine, and saliva, periodontitis, and serum antibody titer tests in dentistry.

Academic Significance and Societal Importance of the Research Achievements

p.g菌 による感染が非アルコール性脂肪性肝疾患(NAFLD)の肝硬度を進行させる,という研究成果の意義は従来の内科治療のみならず,歯科における歯周治療が消化器疾患への関与を示し,国民健康の維持増進に大きく寄与する。これらを基盤とし、生活習慣病であるNAFLDが進行したNASH、さらに肝硬変への病態悪化に焦点を当て、歯周病の病態および歯周病原細菌がNAFLD,NASH発症に与える影響を詳細に明らかにすることが重要である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Relationship between non-alcoholic fatty liver disease and periodontal disease: a review and study protocol on the effect of periodontal treatment on non-alcoholic fatty liver disease2018

    • Author(s)
      Chieko Kudo, Takaomi Kessoku, Yohei Kamata, Koichi Hidaka, Takeo Kurihashi, Tomoyuki Iwasaki, Shogo Takashiba, Toshiro Kodama, Toshiyuki Tamura, Atsushi Nakajima, Masato Minabe
    • Journal Title

      Journal of Translational Science

      Volume: 2(6) Issue: 6 Pages: 340-345

    • DOI

      10.15761/jts.1000160

    • Related Report
      2018 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Porphyromonas gingivalis感染合併非アルコール性脂肪肝疾患に対する病態把握と治療の目安となる歯周組織検査所見の探索 -多施設共同 前向き 観察研究2018

    • Author(s)
      鎌田要平,結束貴臣,清水智子,佐藤五月,青山典生,小林貴,米田正人,畑中加珠,高柴正悟,岩崎知之,栗橋健,井野智,田村利之,児玉利朗,中島淳,三辺正人
    • Organizer
      日本歯周病学会,大阪,2018.10.26.
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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