A new "Psychosomatic Dentistry" based on some biological markers
Project/Area Number |
16K11881
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Social dentistry
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Toyofuku Akira 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10258551)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 歯科心身症 / 歯科心身医学 / 舌痛症 / 口腔セネストパチー / 非定型歯痛 / phantom bite syndrome / 生物学的指標 / 脳機能画像 / SPECT / Phantom bite |
Outline of Final Research Achievements |
Even though the clinical features of oral psychosomatic disorders(Oral-PSD)have been astonishingly common and consistent throughout the world for hundreds of years, Oral-PSD remains an enigma and has evolved to more intractable condition. In fact, there is a large and growing number of elderly Oral-PSD patients for whom the symptom is accompanied by systemic diseases, in addition to aging physical change, which makes the diagnosis and treatment of Oral-PSD difficult. Because the biggest barrier preventing us from finding the core pathophysiology and best therapy for Oral-PSD seems to be its heterogeneity, this syndrome remains challenging for clinicians. In this study, we tried to find some biological markers, which reflect the pathophysiology of Oral-PSD. According to our results, brain perfusion SPECT, change of salivation and QTc interval during pharmachotherapies might be hopeful biomarkers.
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Academic Significance and Societal Importance of the Research Achievements |
生物学的指標の追究により本症の治療法や病態の解明が進展することで、今まで際物扱いされてきた歯科心身医学が諸外国で見直されてきている。その結果、これまで「不定愁訴」扱いされ、医療者から忌避されてきた患者の救済に少しずつつながっている。より本邦の実情に即した本症の医療体制・学問体系が構築されることで、将来的には本邦より海外に向けて「歯科心身症の診断・治療体系」を発信することが可能となると期待される。
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Report
(4 results)
Research Products
(122 results)
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[Journal Article] The QTc shortening with amitriptyline may indicate treatment resistance in chronic nonorganic orofacial pain.2018
Author(s)
Takeshi Watanabe, Kaoru Kawasaki, Trang T.H Tu, Takayuki Suga, Shiori Sugawara, Lou Mikuzuki, Anna Miura, Yukiko Shinohara, Tatsuya Yoshikawa, Miho Takenoshita, Akira Toyofuku, Takahiko Nagamine.
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Journal Title
Clinical Neuropsychopharmacology and Therapeutics
Volume: 9
Pages: 12-14
NAID
Related Report
Peer Reviewed
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[Journal Article] Psychiatric comorbidities in patients with Atypical Odontalgia2018
Author(s)
Miura Anna、Tu Trang T.H.、Shinohara Yukiko、Mikuzuki Lou、Kawasaki Kaoru、Sugawara Shiori、Suga Takayuki、Watanabe Takeshi、Watanabe Motoko、Umezaki Yojiro、Yoshikawa Tatsuya、Motomura Haruhiko、Takenoshita Miho、Maeda Hidefumi、Toyofuku Akira
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Journal Title
Journal of Psychosomatic Research
Volume: 104
Pages: 35-40
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interaction between calcitonin gene-related peptide-immunoreactive neurons and satellite cells via P2Y(12) R in the trigeminal ganglion is involved in neuropathic tongue pain in rats.2017
Author(s)
Sugawara S, Okada S, Katagiri A, Saito H, Suzuki T, Komiya H, Kanno K, Ohara K, Iinuma T, Toyofuku A, Iwata K.
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Journal Title
Eur J Oral Sci.
Volume: 125(6)
Issue: 6
Pages: 444-452
DOI
Related Report
Peer Reviewed
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[Journal Article] Evaluating Burning Mouth Syndrome as a Comorbidity of Atypical Odontalgia: The Impact on Pain Experiences.2017
Author(s)
Tu TTH, Miura A, Shinohara Y, Mikuzuki L, Kawasaki K, Sugawara S, Suga T, Watanabe T, Watanabe M, Umezaki Y, Yoshikawa T, Motomura H, Takenoshita M, Toyofuku A.
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Journal Title
Pain Pract
Volume: -
Issue: 5
Pages: 580-586
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Oral cenesthopathy2016
Author(s)
Umezaki Y, Miura A, Watanabe M, Takenoshita M, Uezato A, Toriihara A, Nishikawa T, Toyofuku A.
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Journal Title
Biopsychosoc Med.
Volume: 10
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Treatment Outcome in Atypical Odontalgia: Determinants of Pain Relief,.2018
Author(s)
TRANG TU, Kaoru Kawasaki, Shiori Sugawara, Anna Miura, Miho Takenoshita, Yukiko Shinohara, Lou Mikuzuki, Takayuki Suga,Akira Toyofuku,
Organizer
The 96th General Session of the IADR
Related Report
Int'l Joint Research
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[Presentation] Clinical study on pain catastrophizing and short-term outcomes of patients with burning mouth syndrome.2018
Author(s)
Miho Takenoshita, Yukiko Shinohara, Lou Mikuzuki, Kaoru Kawasaki, Shiori Sugawara, Tu Thi Huyen Trang, Takayuki Suga, Takeshi Watanabe, Hirofumi Matsuoka, Yoshihiro Abiko, Akira Toyofuku.
Organizer
18th Congress of the ACPM(Asian College of Psychosomatic Medicine)
Related Report
Int'l Joint Research
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[Presentation] New potential pharmacotherapeutic approaches for Atypical Odontalgia.2018
Author(s)
Trang T.H. Tu, Anna Miura, Yukiko Shinohara, Lou Mikuzuki, Kaoru Kawasaki, Shiori Sugawara, Takayuki Suga, Takeshi Watanabe, Yuma Aota, Tatsuya Yoshikawa, Miho Takenoshita, Akira Toyofuku.
Organizer
18th Congress of the ACPM(Asian College of Psychosomatic Medicine)
Related Report
Int'l Joint Research
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[Presentation] PAIN, DEPRESSION AND CATAS- TROPHIZING IN PATIENTS WITH ATYPICAL ODONTALGIA.2018
Author(s)
Trang T.H Tu, Kaoru Kawasaki, Shiori Sugawara, Takeshi Watanabe, Takayuki Suga, Lou Mikuzuki, Yukiko Shinohara, Anna Miura, Miho Takenoshita, Akira Toyofuku
Organizer
32th IADR-SEA (International As- sociation for Dental Research Southeast Asian Division)
Related Report
Int'l Joint Research
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[Presentation] Clinical study on pain catastrophizing of patients with burning mouth syndrome and atypical odontalgia2017
Author(s)
Miho Takenoshita, Anna Miura, Yukiko Shinohara, Rou Mikuzuki, Kaoru Kawasaki, Shiori Sugawara, Trang Tu Thi Huyen, Takayuki Suga, Takeshi Watanabe, Hirofumi Matsuoka, Yoshihiro Abiko, Akira Toyofuku
Organizer
24th Wolrd congress on psychosomatic medicine
Related Report
Int'l Joint Research
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[Presentation] Clinicostatistical Study on the Pa- tients with Oral Cenesthopathy.2016
Author(s)
Yojiro Umezaki, Anna Miura, Yukiko Shinohara, Lou Mikuzuki, Shiori Sugawara, Kaoru Kawasaki, Takeru Kyuragi, Motoko Watanabe, Miho Takenoshita, Akira Toyofuku
Organizer
17th Congress of the Asian College of Psychosomatic Medicine (ACPM)
Place of Presentation
Fukuoka, Japan
Year and Date
2016-08-21
Related Report
Int'l Joint Research
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[Presentation] Two Cases of Atypical Odontalgia Suc- cessfully Treated by Adding Low-Dose of Aripiprazole to Mirtazapine.2016
Author(s)
Miho TAKENOSHITA, Anna MIURA, Yukiko SHINOHARA, Lou MIKUZUKI, Kaoru KAWASAKI, Sh- iori SUGAWARA, Trang THI HUYEN YU, Takeru KYURAGI, Yojiro UMEZAKI,Motoko WATANABE, Ayano KATAGIRI, Tatsuya YOSHIKAWA, Akira TOYOFUKU.
Organizer
17th Congress of the Asian College of Psychosomatic Medicine (ACPM)
Place of Presentation
Fukuoka, Japan
Year and Date
2016-08-21
Related Report
Int'l Joint Research
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[Presentation] 顎変形症と心の病.2016
Author(s)
豊福 明
Organizer
第 26 回日本顎変形症学会
Place of Presentation
東京医科歯科大学、東京都文京区
Year and Date
2016-06-26
Related Report
Invited
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