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Deriving a regression model for saliva flow rate in the elderly : a longitudinal study.

Research Project

Project/Area Number 16K11884
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionNiigata University

Principal Investigator

Nohno Kaname  新潟大学, 医歯学総合病院, 講師 (80422608)

Co-Investigator(Kenkyū-buntansha) 金子 昇  新潟大学, 医歯学系, 助教 (00397126)
伊藤 加代子  新潟大学, 医歯学総合病院, 助教 (80401735)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords唾液量 / 高齢者 / 口腔乾燥 / 唾液量減少 / 唾液 / 歯学
Outline of Final Research Achievements

The purpose of this study was to examine the factors related to the decrease in salivary flow rates of the elderly in 10-year longitudinal study. We measured the stimulated salivary flow rates (SSFR) and unstimulated salivary flow rate (USFR), blood tests, stress test, and lifestyle habits when the subjects were 80 and 90 years old. We found that a mean decrease of 20% of SSFR and 10% of USFR in 10 years. As a results, female gender, reduced renal function, and β3 adrenergic receptor genotype were suggested as risk factors for decrease in salivary flow rates.

Academic Significance and Societal Importance of the Research Achievements

唾液量減少(口腔乾燥)はむし歯や歯周病といった歯科疾患のリスクになるだけではなく、食事の難しさ等に影響する。唾液量に関連する因子は複数報告されているが、本研究では高齢者において10年後の唾液量減少を予測する因子を検討した。その結果、性別(女性)や腎機能低下がその因子として認められた。また、β3アドレナリン受容体遺伝子型も因子となることが示唆され、今後の口腔乾燥治療に対する新たな知見となった。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2020 2018 2017

All Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Beta-3 Adrenergic Receptor Gene is associated with Depressive Hyposalivation.2020

    • Author(s)
      Nohno K, Yoshihara A, Kaneko N, Ogawa H.
    • Organizer
      2020 International Association for Dental Research (Washington, D.C. USA)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地域在住高齢者における唾液量と血中コレステロールの関連2018

    • Author(s)
      溝口奈菜 、濃野 要、金子 昇、小川祐司、葭原明弘
    • Organizer
      甲信越北陸口腔保健研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 地域在住高齢者における安静時唾液量とβ-3 adrenergic receptor 遺伝子多型の関連2017

    • Author(s)
      濃野 要、葭原明弘、金子 昇、伊藤加代子、船山さおり、溝口奈菜、宮崎秀夫
    • Organizer
      第66回日本口腔衛生学会・総会
    • Place of Presentation
      山形テルサ(山形県・山形市)
    • Year and Date
      2017-05-31
    • Related Report
      2016 Research-status Report
  • [Presentation] 地域在住高齢者における安静時唾液量とβ3 adrenergic receptor 遺伝子多型の関連2017

    • Author(s)
      濃野要、葭原明弘、金子 昇、伊藤加代子、船山さおり、溝口奈菜、宮崎秀夫
    • Organizer
      第66回 口腔衛生学会・総会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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