• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effects of esophageal mechanical stimulations on the initiation of swallowing reflex

Research Project

Project/Area Number 16K11903
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionAsahi University (2018)
Fujita Health University (2016-2017)

Principal Investigator

Taniguchi Hiroshige  朝日大学, 歯学部, 准教授 (80529636)

Co-Investigator(Kenkyū-buntansha) 松尾 浩一郎  藤田医科大学, 医学部, 教授 (90507675)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords嚥下反射誘発 / 食道刺激 / 嚥下反射 / 摂食嚥下障害 / 嚥下誘発 / 食道 / 嚥下障害
Outline of Final Research Achievements

The swallowing reflex is known to be evoked by gastroesophageal regurgitation or esophageal stimulation in animal studies. However, details regarding the stimulating material, bolus size, and stimulation area remain unclear for the stimulation-induced type of swallowing reflex in human. Here, we evaluated the effects of different kinds of stimulation via water injection of the esophagus on the initiation of the swallowing reflex. Our findings suggest that while the swallowing reflex is evoked by varying types of stimulation via fluid injection of the esophagus in human, sensitivity is greatest in the upper region of the esophagus compared with the lower region, and can vary depending on the injecting material.

Academic Significance and Societal Importance of the Research Achievements

日本は,人口の高齢化に伴い摂食嚥下機能に障害を来たした要介護高齢者の問題が顕在化している。さらに,多くの患者は誤嚥性肺炎を回避するために胃瘻などの非経口的栄養摂取を余儀なくされ,口から食べる機会を奪われてしまっている。その一因として,重度嚥下障害者に対しては有効な嚥下訓練法が確立されていないため,廃用によって嚥下障害は進行し誤嚥性肺炎が引き起こされている。
その問題を解決するため,申請者らは,食道刺激によって誘発される嚥下運動が訓練として使用できないか検討してきた。本研究は基礎研究であるが,本手法が嚥下障害者にも適応できれば“革新的な訓練法”として使用できる可能性があると我々は考えている。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (14 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Development of an oesophageal stimulation method to elicit swallowing reflex in humans2018

    • Author(s)
      Taniguchi H.、Aoyagi Y.、Matsuo K.、Nakagawa K.、Saitoh E.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 45 Issue: 3 Pages: 211-215

    • DOI

      10.1111/joor.12599

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 間歇的口腔食道経管栄養法に関する一考察-注入する液体の温度と体幹角度の違いによる検討-2019

    • Author(s)
      谷口裕重
    • Organizer
      第34回日本静脈経腸栄養学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食道刺激を利用した,ヒト嚥下運動を誘発する新たな手法の開発2018

    • Author(s)
      谷口裕重
    • Organizer
      日本老年歯科医学会第29回学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of posture and temperature in eliciting swallowing reflex by esophageal stimulation in humans2018

    • Author(s)
      Hiroshige Taniguchi
    • Organizer
      The 24nd Annual Meeting of the Japanese Society of Dysphagia Rehabilitation
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of volume and viscosity on esophageal pressure during swallowing: a study using high resolution manometry2018

    • Author(s)
      Yuri Nakazawa,Hiroshige Taniguchi
    • Organizer
      24th Japan-Korea Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 液体の量および粘性度が嚥下運動時の食道内圧に与える影響2018

    • Author(s)
      中澤悠里,谷口裕重
    • Organizer
      第35回日本障害者歯科学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 食道内刺激による嚥下反射誘発~刺激温度の検討~2018

    • Author(s)
      谷口裕重
    • Organizer
      第35回日本障害者歯科学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 間歇的口腔食道経管栄養法に関する一考察-食道内注入部位による検討-2018

    • Author(s)
      谷口裕重
    • Organizer
      第33回日本静脈経腸栄養学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of an esophageal mechanical stimulation method for eliciting the swallowing reflex in healthy Individuals -Difference in injected region-2018

    • Author(s)
      Hiroshige Taniguchi
    • Organizer
      The Dysphagia Research Society 23rd Annual Meeting
    • Related Report
      2017 Research-status Report
  • [Presentation] Effect of temperature in eliciting swallowing reflex by esophageal stimulation in humans2018

    • Author(s)
      Yoichiro Aoyagi, Hiroshige Taniguchi
    • Organizer
      The Dysphagia Research Society 23rd Annual Meeting
    • Related Report
      2017 Research-status Report
  • [Presentation] ヒト嚥下運動を誘発する新たな手法の開発-食道刺激を利用した方法-2017

    • Author(s)
      谷口裕重
    • Organizer
      第28回日本老年歯科医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 嚥下運動を誘発する新たな手法の開発-食道刺激を利用した方法-2017

    • Author(s)
      谷口裕重
    • Organizer
      第23回日本摂食嚥下リハビリテーション学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of an esophageal mechanical stimulation method for eliciting the swallowing reflex in healthy young participants2017

    • Author(s)
      Hiroshige Taniguchi
    • Organizer
      7th European Society for Swallowing Disorders
    • Related Report
      2017 Research-status Report
  • [Presentation] 食道刺激で誘発される嚥下運動を利用した新たな手法の開発2017

    • Author(s)
      谷口裕重
    • Organizer
      第34回日本障害者歯科学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 咀嚼運動が咽頭への機械刺激によって誘発される嚥下反射惹起に及ぼす影響2016

    • Author(s)
      谷口 裕重
    • Organizer
      第33回日本障害者歯科学会学術大会
    • Place of Presentation
      埼玉県さいたま市
    • Year and Date
      2016-09-30
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi