| Project/Area Number |
16K12521
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIKAWA Daisuke 首都大学東京, 大学院都市環境科学研究科, 特任助教 (00722919)
KAWANO Ryuji 東京農工大学, 工学研究院, 特任准教授 (90401702)
ENDO Masayuki 京都大学, 物質-細胞統合システム拠点, 准教授 (70335389)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分子ロボット / 人工細胞 / DNAナノテクノロジー / DNAオリガミ / マイクロ油中水滴 / マイクロ流体デバイス / 自己組織化 / ピッカリングエマルション / 油中水滴 / カプセル / マイクロ流路 |
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| Outline of Final Research Achievements |
In this study, we studied the construction of cell-like molecular robots. The molecular robots were made of DNA nanostructures produced by bottom-up assembly of designed DNA, and the molecular robots were produced on an oil-water interface controlled by microfluidic technology. Here, the function was constructed with designed nanometer-sized DNA, which was usually generated by DNA origami technology. The DNA nanodevices were functionalized into amphiphilic molecules and were self-assembled on the oil-water interface of microdroplets. Finally, we developed some basic methods to programmably construct dynamical molecular robot with functions such as molecular sensing, self-propelled motions, etc.
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