Dynamical cell-like molecular robots with programmability based on the control of DNA nanostructures on microinterface
| Project/Area Number |
16K12521
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIKAWA Daisuke 首都大学東京, 大学院都市環境科学研究科, 特任助教 (00722919)
KAWANO Ryuji 東京農工大学, 工学研究院, 特任准教授 (90401702)
ENDO Masayuki 京都大学, 物質-細胞統合システム拠点, 准教授 (70335389)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分子ロボット / 人工細胞 / DNAナノテクノロジー / DNAオリガミ / マイクロ油中水滴 / マイクロ流体デバイス / 自己組織化 / ピッカリングエマルション / 油中水滴 / カプセル / マイクロ流路 |
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| Outline of Final Research Achievements |
In this study, we studied the construction of cell-like molecular robots. The molecular robots were made of DNA nanostructures produced by bottom-up assembly of designed DNA, and the molecular robots were produced on an oil-water interface controlled by microfluidic technology. Here, the function was constructed with designed nanometer-sized DNA, which was usually generated by DNA origami technology. The DNA nanodevices were functionalized into amphiphilic molecules and were self-assembled on the oil-water interface of microdroplets. Finally, we developed some basic methods to programmably construct dynamical molecular robot with functions such as molecular sensing, self-propelled motions, etc.
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Report
(3 results)
Research Products
(56 results)
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[Presentation] プログラマブルな性質を有するDNA ナノプレートからなるマイクロカプセルの形成, Microcapsular compartments composed of programmable DNA nanoplates2016
Author(s)
Daisuke Ishikawa, Yuki Suzuki, Chikako Kurokawa, Masayuki Ohara, Misato Tsuchiya, Masamune Morita, Miho Yanagisawa, Ryuji Kawano, Masayuki Endo, Masahiro Takinoue
Organizer
第54回日本生物物理学会
Place of Presentation
つくば国際会議場, 茨城
Year and Date
2016-11-25
Related Report
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[Presentation] Self-Assembled Microcapsule of Amphiphilic Janus DNA Nanoplates at the Water-Oil Interface2016
Author(s)
Daisuke Ishikawa, Yuki Suzuki, Chikako Kurokawa, Masayuki Ohara, Masamune Morita, Miho Yanagisawa, Ryuji Kawano, Masayuki Endo, *Masahiro Takinoue
Organizer
The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2016)
Place of Presentation
Convention Center Dublin, Dublin, Ireland
Year and Date
2016-10-09
Related Report
Int'l Joint Research
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[Presentation] 荷電脂質膜界面における DNA ミクロ構造の形成2016
Author(s)
森田雅宗, 石川大輔, 野村 M. 慎一郎, 村田智, 柳澤実穂, 瀧ノ上正浩
Organizer
化学とマイクロ・ナノシステム学会 第33回研究会 (CHEMINAS33)
Place of Presentation
東京大学生産技術研究所, 東京
Year and Date
2016-04-25
Related Report
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