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Empirical proof of multiplex communication identification in cultured neuronal network

Research Project

Project/Area Number 16K12524
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Life / Health / Medical informatics
Research InstitutionOsaka University

Principal Investigator

Tamura Shinichi  大阪大学, その他部局等, 名誉教授 (30029540)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords神経回路網 / 多重通信 / 機械学習 / スパイク波 / 神経の揺らぎ / リレーニューロン / 培養神経回路網 / シミュレーション / Natural neural network / Multiplex communication / Learning / Spike wave / Fluctuation of neuron / Relay neuron / ニューラルネットワーク / 刺激発信源 / 識別学習 / 高速化 / 脳内情報 / 培養神経細胞 / 脳型情報処理 / 知能回路原理
Outline of Final Research Achievements

As an intermediate level approach between AI and neuroscience, behaviors of artificial neural network have been elucidated. However, since functions of the neural network have not been enough elucidated, we are studying the intermediate level function of the neural network focused on signal transmission or communication function. In 25×25 mesh neural network simulation, we have confirmed it is possible to set asynchronous multiplex communication channel such as 9:9. Corresponding to these, we showed we can set communication channels such as 3:n in wet experiments on cultured neuronal networks. That is, several receiving neurons (group) away from the stimulated neurons (group) could classify/recognize what kind of stimulation was added based on the arrived spike waves. Both of the simulation in artificial neural networks and the experiment in cultured neuronal networks support the multiplex communication scheme in the brain.

Academic Significance and Societal Importance of the Research Achievements

脳神経回路について,マクロ的視点からは,AIや深層学習の研究が進んできた.ミクロ的視点からは,神経自体の特性や動作,また中間レベルの神経回路網の特性や振る舞いについてもよく研究されてきた.しかしながら神経回路網の機能については十分研究されていない.本研究は,情報伝達・通信の視点から,シミュレーションと,培養神経回路の対応を取りつつ,神経回路網の機能について研究を行ってきたものである.
その結果,神経回路網では空間的多重通信が行われているであろうことが結論された.これはシミュレーションと培養神経における実験の両面から,神経回路網内の多重通信原理を指摘・解明した最初の研究である.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2019 2018 2017 2016 Other

All Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results,  Open Access: 10 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 4 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Asynchronous multiplex communication channels in 2D neural network with fluctuating characteristics2018

    • Author(s)
      Shinichi Tamura, Yoshi Nishitani, Chie Hosokawa, Yuko Mizuno-Matsumoto
    • Journal Title

      IEEE Transactions on Neural Networks and Learning Systems

      Volume: 99 Issue: 8 Pages: 1-10

    • DOI

      10.1109/tnnls.2018.2880565

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of correlating adjacent neurons for identifying communications: Feasibility experiment in a cultured neuronal network2018

    • Author(s)
      Yoshi Nishitani, Chie Hosokawa, Yuko Mizuno-Matsumoto, Tomomitsu Miyoshi, Shinichi Tamura
    • Journal Title

      AIMS Neuroscience

      Volume: 5 Issue: 1 Pages: 13-31

    • DOI

      10.3934/neuroscience.2018.1.18

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accurate Pelvis and Femur Segmentation in Hip CT With a Novel Patch-based Refinement2018

    • Author(s)
      Yong Chang, Yongfeng Yuan, Changyong Guo, Yadong Wang, Yuanzhi Cheng, Shinichi Tamura
    • Journal Title

      IEEE Journal of Biomedical and Health Informatics

      Volume: - Issue: 3 Pages: 1192-1204

    • DOI

      10.1109/jbhi.2018.2834551

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Vector Field Convolution Based B-Spline Deformation Model for 3D Segmentation of Cartilage in MRI2018

    • Author(s)
      Jinke Wang, Changfa Shi, Yuanzhi Cheng, Shinichi Tamura
    • Journal Title

      Symmetry

      Volume: 10 Issue: 11 Pages: 591-591

    • DOI

      10.3390/sym10110591

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 3D surface voxel tracing corrector for accurate bone segmentation2018

    • Author(s)
      Guo Haoyan、Song Sicong、Wang Jinke、Guo Maozu、Cheng Yuanzhi、Wang Yadong、Tamura Shinichi
    • Journal Title

      International Journal of Computer Assisted Radiology and Surgery

      Volume: 13 Issue: 10 Pages: 1549-1563

    • DOI

      10.1007/s11548-018-1804-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Liver Segmentation Based on Hybrid-Distance Regularized Level Set Evolution Combining Region Growing in Abdominal Computed Tomography2018

    • Author(s)
      Wang Jinke, Guo Haoyan, Tamura Shinichi
    • Journal Title

      Journal of Medical Imaging and Health Informatics

      Volume: 8 Issue: 7 Pages: 1436-1441

    • DOI

      10.1166/jmihi.2018.2452

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Learning Times Required to Identify the Stimulated Position and Shortening of Propagation Path by Hebb’s Rule in Neural Network2017

    • Author(s)
      Shun Sakuma Yuko Mizuno-Matsumoto Yoshi Nishitani Shinichi Tamura
    • Journal Title

      AIMS Neuroscience

      Volume: 4 Issue: 4 Pages: 238-253

    • DOI

      10.3934/neuroscience.2017.4.238

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Classification of spike wave propagations in a cultured neuronal network: Investigating a brain communication mechanism2017

    • Author(s)
      Y. Nishitani, C. Hosokawa, Y. Mizuno-Matsumoto, T. Miyoshi and S. Tamura
    • Journal Title

      AIMS Neuroscience

      Volume: 4 Issue: 1 Pages: 1-13

    • DOI

      10.3934/neuroscience.2017.1.1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feasibility of multiplex communication in a 2D mesh asynchronous neural network with fluctuations2016

    • Author(s)
      S. Tamura, Y. Nishitani and C. Hosokawa
    • Journal Title

      AIMS Neuroscience

      Volume: 3 Issue: 4 Pages: 385-397

    • DOI

      10.3934/neuroscience.2016.4.385

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simulation of Spike Wave Propagation and Two-to-one Communication with Dynamic Time Warping2016

    • Author(s)
      Shun Sakuma 1, Yuko Mizuno-Matsumoto , Yoshi Nishitani , Shinichi Tamura
    • Journal Title

      AIMS Neuroscience

      Volume: 3(4) Issue: 4 Pages: 474-486

    • DOI

      10.3934/neuroscience.2016.4.474

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Multiplex communication in neural network by asynchronous spike wave propagation2018

    • Author(s)
      Shinichi Tamura, Yoshi Nishitani, Chie Hosokawa, Tomomitsu Miyoshi, Yuko Mizuno-Matsumoto, Yen-Wei Chen
    • Organizer
      11th FENS (Federation of European Neuroscience Societies) Forum
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経回路網におけるスパイク波伝播とDTW法による発信源識別2017

    • Author(s)
      佐久間俊、西谷陽志、水野(松本)由子、田村進一
    • Organizer
      第12回日本感性工学会春季大会
    • Place of Presentation
      大阪
    • Year and Date
      2017-03-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Multiplex Communication by Series of Laplacian Gaussian Filters in 2D Mesh Neural Network2017

    • Author(s)
      Shinichi Tamura, Yoshi Nishitani, Chie Hosokawa, Tomomitsu Miyoshi, Yuko Mizuno-Matsumoto, Yen-Wei Chen
    • Organizer
      4th Int’l Conf. on Mechanical Electronics and Computer Engineering (CMECE 2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経回路網シミュレーションにおける刺激位置の識別に要する学習回数とHebb則による伝播経路の短縮2017

    • Author(s)
      佐久間俊,西谷陽志,水野(松本)由子,田村進一
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Simulation of spike propagation in neural network2016

    • Author(s)
      Sakuma Shun, Mizuno-Matsumoto Yuko, Nishitani Yoshi, Tamura Shinichi
    • Organizer
      8th International Workshop on Bio signal Interpretation (BSI2016)
    • Place of Presentation
      大阪
    • Year and Date
      2016-11-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multiplex communication by BP learning in neural network2016

    • Author(s)
      Shinichi Tamura, Yoshi Nishitani, Chie Hosokawa, Tomomitsu Miyoshi, Hajime Sawai, Yuko Mizuno-Matsumoto, Yen-Wei Chen
    • Organizer
      CISP-BMEI
    • Place of Presentation
      中国 大同
    • Year and Date
      2016-10-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] Chapter "Multiplex signal transmission in neural network by spike waves" in Computational Intelligence: Advances in Research and Applications2019

    • Author(s)
      Shinichi Tamura and Yoshi Nishitani
    • Publisher
      Nova Science Publishers, Inc.
    • Related Report
      2018 Annual Research Report
  • [Remarks] (1) 株式会社NBL研究所の研究業績

    • URL

      http://www.nbl-technovator.jp/NBL_Tech/files/paper_list.pdf

    • Related Report
      2018 Annual Research Report
  • [Remarks] (2) Researchmap

    • URL

      https://researchmap.jp/read0014490/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 株式会社NBL研究所の研究業績

    • URL

      http://www.nbl-technovator.jp/NBL_Tech/files/paper_list.pdf

    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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