| Project/Area Number |
16K12603
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Risk sciences of radiation and chemicals
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
WADA HIROMI 北海道大学, 文学研究科, 教授 (90191832)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | ultrasonic vocalization / rat / BDE-209 / maternal separation / play fighting / mating behavior / fighting behavior / communication / 超音波発声 / ラット / PBDE / USV / 母子分離 / 仲間遊び / ペアリング / 順位争い / 有害化学物質 / モニタリング / 解析・評価 |
|---|
| Outline of Final Research Achievements |
BDE-209 was administered to pregnant rats at dosages of 1000, 500, or 0mg/kg from gestational day 15 to postnatal day 21. The duration of ultrasonic vocalizations (USVs) was shortened and frequency-modulated USVs were reduced in the dosed pups. Only male high-dose groups of juvenile rats produced 30 kHz USVs with longer durations (type N call) in play fighting. Male adult rats of the low-dose and control groups produced type N calls in mating behavior whereas those of the high-dose group disappeared them. In fighting behavior, male rats of the control group produced type N call but those of the high- and low-dose groups reduced or disappeared them. These results suggest that BDE-209 disrupts communication behavior of rats.
|
