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Synergistic effect of polyphenol and protein to promote recovery from muscle atrophy

Research Project

Project/Area Number 16K12721
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionThe University of Tokushima

Principal Investigator

MUKAI Rie  徳島大学, 大学院社会産業理工学研究部(生物資源産業学域), 准教授 (90547978)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsフラボノイド / ポリフェノール / タンパク質 / アミノ酸 / 骨格筋 / 筋萎縮 / 健康 / 機能性食品 / 食品成分
Outline of Final Research Achievements

It has been demonstrated that the synergistic effect of polyphenol and protein on muscle recovery from muscle atrophy. Our result indicated that satisfaction of protein as basic nutrient was necessary for exerting beneficial effect of flavonoid on muscle recovery. However, the amount of free amino acid, and the gene expression of amino acid transporters in skeletal muscle were not regulated by polyphenol intake.

Academic Significance and Societal Importance of the Research Achievements

ポリフェノールの生理機能性研究では、ある条件下での効果に着目し研究を進めることが多い。一方、日常の食生活を基盤としたポリフェノールの機能性研究は疫学調査が中心であった。本課題はこれらの溝を埋めるべく、食事に含まれる栄養素の違いによってポリフェノールの生理活性に変化がでることを明らかにしようとする試みであった。本申請課題の遂行により、ポリフェノールが食品成分として骨格筋萎縮に対する予防機能を発揮する要件として、タンパク質栄養の充足の重要性を示唆することができた。本成果は食生活における骨格筋維持に対する食品成分の役割を明らかにすることに繋がることが期待される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] Prenylation enhances the biological activity of dietary flavonoids by altering their bioavailability2018

    • Author(s)
      Mukai Rie
    • Journal Title

      Bioscience Biotechnology and Biochemistry

      Volume: 82 Issue: 2 Pages: 207-215

    • DOI

      10.1080/09168451.2017.1415750

    • NAID

      120006547010

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice2016

    • Author(s)
      Mukai R, Horikawa H, Lin PY, Tsukumo N, Nikawa T, Kawamura T, Nemoto H, Terao J*
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 311 Issue: 6 Pages: 1022-1031

    • DOI

      10.1152/ajpregu.00521.2015

    • NAID

      120006535072

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 植物ポリフェノールによる筋萎縮予防の可能性2016

    • Author(s)
      向井理恵
    • Journal Title

      日本農芸化学会会誌「化学と生物」

      Volume: 54 Pages: 841-846

    • NAID

      130006176503

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] レモン果皮抽出物の筋萎縮予防効果について2019

    • Author(s)
      高瀬貴仁、小林直之、井上孝司、土屋陽一、向井理恵
    • Organizer
      日本食品科学工学 第66回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 筋タンパク質合成時にプレニルナリンゲニンが引き起こす骨格筋内代謝物の変動2019

    • Author(s)
      田中寛人、西海信、堤理恵、向井理恵
    • Organizer
      日本ポリフェノール研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Estrogenic activity of 8-renylnaringenin improve skeletal muscle regeneration from disuse muscle atrophy by activating IGF-I/PI3K/Akt pathway2019

    • Author(s)
      Rie Mukai, Hisao Nemoto, Junji Terao
    • Organizer
      ICoFF2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preventive effect of dietary lemon peel extract containing eriocitrin on disuse muscle atrophy in denervated mice2019

    • Author(s)
      Takahito Takase, Naoyuki Kobayashi, Takashi Inoue, Yoichi Tsuchiya, Rie Mukai
    • Organizer
      ICoFF2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Binding profile of quercetin and its derivatives to human serum albumin measured by multiplex drug-site mapping2019

    • Author(s)
      Hitomi Okuyama, Mayumi Ikeda, Yu Ishima, Miyu Nishikawa, Shinichi Ikushiro, Rie Mukai
    • Organizer
      ICPH2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食品機能学によるプレニルフラボノイドの特性解明2018

    • Author(s)
      向井理恵
    • Organizer
      日本農芸化学会中四国支部第50回記念講演会(例会)
    • Related Report
      2017 Research-status Report
  • [Presentation] 食品機能学によるプレニルフラボノイドの特性解明2017

    • Author(s)
      向井理恵
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] フラボノイドのプレニル化による生体利用性の変化と機能性の増強2016

    • Author(s)
      向井 理恵
    • Organizer
      日本農芸化学会中四国支部・第 23 回若手シンポジウム
    • Place of Presentation
      岡山大学(岡山県岡山市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2023-12-25  

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