| Project/Area Number |
16K12862
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Hokkaido University |
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Principal Investigator |
Hirata Hiroshi 北海道大学, 情報科学研究科, 教授 (60250958)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Shingo 北海道大学, 大学院情報科学研究科, 准教授 (90741041)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 腫瘍 / 放射線 / 酸素分圧 / 画像 / 可視化 / 計測工学 / 癌 / 生物・生体工学 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the outcomes of the model experiments of oxygen partial pressure-guided radiation therapy. A miniature multi-leaf collimator (MLC) was developed for the model experiments using tumor-bearing mice. This miniature MLC was planned to control the intensity and the distribution of X-ray irradiation to tumor model mice. Also, the computation method for obtaining the collimator opening from the three-dimensional data of oxygen partial pressure in mouse tumors was developed and implemented. Moreover, tumor-growth curves were obtained for non-treated and uniform X-ray irradiated mice. These data will be the control data of tumor growth. For preparing tumor-bearing mice, murine squamous cell carcinoma (SCC VII) cells were subcutaneously implanted in mouse hind legs.
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