| Project/Area Number |
16K12865
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Ibaraki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO TAKEO 名古屋大学, 大学院工学研究科, 教授 (30209639)
SUGAWARA MICHIKO 千葉大学, 大学院工学研究科, 准教授 (30323041)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞骨格 / 細胞核 / メカノバイオロジー / 細胞計測・操作 / 細胞バイオメカニクス / 細胞運動 |
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| Outline of Final Research Achievements |
We investigated the mechanism of a mechanical memory of the intracelualr forces and structures with consideration for cell aging. We used vascular smooth muscle cells and found that cell aging increased cell projected area while it reduced intracellular tension and migration ability. We further found that tensional memory of actin stress fibers in vascular smooth muscle cells tended to decrease with cell aging. These results indicate that cell aging not only affects cell morphology and biochemical functions but also mechanical propeties of cells involving in cellular mechanotransduction.
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