Development of fluorescence lifetime measurement for glycation screening for diabetes in vivo
| Project/Area Number |
16K12877
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University |
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Principal Investigator |
Miura Jiro 大阪大学, 歯学部附属病院, 助教 (70437383)
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| Co-Investigator(Kenkyū-buntansha) |
橋本 守 北海道大学, 情報科学研究科, 教授 (70237949)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 糖化 / メイラード反応 / 蛍光寿命 / コラーゲン / 老化 / 糖尿病 / 象牙質 / ナノ秒蛍光 |
|---|
| Outline of Final Research Achievements |
Glycation, namely the Maillard reaction, is a non-enzymatic reaction between protein or lipid and reducing sugar, resulting in formation of advanced glycation end-products (AGEs). Because glycation of collagen progresses under physiological conditions in living organisms, glycation is one of the most important processes in human aging. Several AGEs bind collagen and act as cross-links between collagen fibrils, thereby changing the fluorescent lifetime of collagen-rich tissues. The purpose of this study is to identify AGEs in human dentin using electron microscopy, time-resolved fluorescence microscopy, mechanical testing and chemical analyses. Our findings suggest the potential influence of cross-linking on diabetic and aging tissue.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Adhesion procedure for CAD/CAM resin crown bonding: Reduction of bond strengths due to artificial saliva contamination2018
Author(s)
Kawaguchi-Uemura A, Mine A, Matsumoto M, Tajiri Y, Higashi M, Kabetani T, Hagino R, Imai D, Minamino T, Miura J, Yatani H.
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Journal Title
Journal of Prosthodontic Research
Volume: 62
Issue: 2
Pages: 177-183
DOI
NAID
ISSN
1883-1958, 1883-9207
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effectiveness of sodium hypochlorite and sulfinic acid sodium salt treatment on dentin-resin bonding: Long-term durability of one-step self-etching adhesive2017
Author(s)
Nakatani H, Mine A, Matsumoto M, Kabetani T, Kawaguchi-Uemura A, Higashi M, Tajiri Y, Imai D, Hagino R, Minamino T, Miura J, Yatani H.
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Journal Title
Dental Materials Journal
Volume: 36
Issue: 6
Pages: 842-850
DOI
NAID
ISSN
0287-4547, 1881-1361
Related Report
Peer Reviewed / Open Access
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[Journal Article] Temporal dynamics of bacterial microbiota in the human oral cavity determined using an in situ model of dental biofilms2016
Author(s)
Wake N, Asahi Y, Noiri Y, Hayashi M, Motooka D, Nakamura S, Gotoh K, Miura J, Machi H, Iida T, Ebisu S.
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Journal Title
npj Biofilms and Microbiome
Volume: 2
Issue: 1
Pages: 16018-16018
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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