Multi-level analysis of ischemic heart disease pathology based on heterogeneity in mechano-electric coupling

• Project/Area Number: 16K12878
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Okayama University
• Principal Investigator: Iribe Gentaro 岡山大学, 医歯薬学総合研究科, 准教授 (90284885)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 虚血性心疾患 / 心筋メカニクス / 不均一性 / 数理モデル / 生理学 / 循環器 / フィジオーム

Outline of Final Research Achievements

Myocardial cellular function is different between endocardial and epicardial cells. It is not clear how ischemic condition affects this transmural heterogeneity. In the present study, we isolate the cells from epicardium and endocardium to compare the response of their mechanical properties to stretch. We found that ischemic condition reduces the transmural heterogeneity in the response to stretch. The present findings may provide new insight into pathophysiology of ischemic heart disease.

Research Products

• [Int'l Joint Research] Institute of Immunology and Physiology/B. N. Yeltsin Ural Federal University(ロシア連邦)
• [Journal Article] The effects of load on transmural differences in contraction of isolated mouse ventricular cardiomyocytes (2018)
  • Author(s): Khokhlova Anastasia、Iribe Gentaro、Katsnelson Leonid、Naruse Keiji、Solovyova Olga
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 114 Pages: 276-287
  • DOI: 10.1016/j.yjmcc.2017.12.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Transmural cellular heterogeneity in myocardial electromechanics (2017)
  • Author(s): Khokhlova Anastasia、Balakina-Vikulova Nathalie、Katsnelson Leonid、Iribe Gentaro、Solovyova Olga
  • Journal Title: The Journal of Physiological Sciences Volume: - Issue: 4 Pages: 387-413
  • DOI: 10.1007/s12576-017-0541-0
  • NAID: 40021574355
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of simulated ischemia on the transmural differences in the Frank?Starling relationship in isolated mouse ventricular cardiomyocytes (2017)
  • Author(s): Khokhlova Anastasia、Iribe Gentaro、Yamaguchi Yohei、Naruse Keiji、Solovyova Olga
  • Journal Title: Progress in Biophysics and Molecular Biology Volume: 130 Pages: 323-332
  • DOI: 10.1016/j.pbiomolbio.2017.05.011
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Role of myocardial subcellular mechano-sensitivity in integrative cardiac function (2018)
  • Author(s): Iribe G
  • Organizer: Korea-Japan Joint Symposium (-Towards FAOPS2019) 「Exquisite mechanisms for sensing and orchestrating mechanical signals」 the 95th Annual Meeting of the Physiological Society of Japan
  • Int'l Joint Research / Invited
• [Presentation] Changes in contractile function of subendocardial and subepicardial cardiomyocytes induced by acute ischemia (2016)
  • Author(s): Khokhlova A, Iribe G & Solovyova O
  • Organizer: 7th International Workshop Cardiac Mechano-Electric Coupling and Arrhythmias
  • Place of Presentation: Freiburg, Germany
  • Year and Date: 2016-09-16
  • Int'l Joint Research