| Project/Area Number |
16K12879
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biomedical engineering/Biomaterial science and engineering
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
水本 博 九州大学, 工学研究院, 准教授 (90346817)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 幹細胞 / 分化 / ハイドロゲル / 増殖因子 / メカノトランスダクション / iPS細胞 / 力学特性 / 細胞運命制御 / 増殖因子固定化基材 / ヘパリン / 生物・生体工学 / 再生医工学 / 生体材料 |
|---|
| Outline of Final Research Achievements |
This research attempted to combine the advantages of the control of growth factors and the adjustable mechanical properties of the scaffold, to provide variety choice for scaffold design. We focus on the heparin as a growth factor-immobilization agent, and we prepared heparin-conjugated collagen gel. We also built crosslink between the collagen fibers to change the mechanical properties. By using heparin-conjugated collagen gel and immobilizing some growth factors, the survival and functions of cultured cells were up-regulated. On the other hand, the research on the change of the mechanical properties, which could cause by the cross-linking level of the substrate itself, showed the influence on the state of the cells. In the future, this study would contribute to the investigation of the mechanisms underlying cell-fate decisions.
|
