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Influence of the water signal on the excitation light in non-invasive blood glucose level measurement

Research Project

Project/Area Number 16K12881
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionMeiji University

Principal Investigator

Ishihara Yasutoshi  明治大学, 理工学部, 専任教授 (00377219)

Research Collaborator OKADA Koh  
TACHIBANA Kohei  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords非侵襲 / 血糖値 / 計測 / 近赤外光 / 吸光度 / 糖尿病 / グルコース / 吸光スペクトル / 近赤外分光 / 水 / 生体医工学
Outline of Final Research Achievements

No prospect of actually using non-invasive blood glucose level measurement has yet emerged. Several main reasons are that the glucose concentration in blood is low, and that it cannot carry out the separation measurement of the glucose from water.
We have proposed a method that the ratio of the water signal to an observation signal could be estimated by superimposing the excitation light corresponding to the absorption peak of water (1450 nm) on measurement light (1600 nm). It was shown clearly by the experiments in this study that measurement light intensity increases with excitation light intensity in glucose solution. It was also indicated quantitatively that this signal change is an effect according to heat in addition to the effect by light. A possibility that the separation measurement of the glucose signal could be exactly carried out from an observation signal was indicated by using these effects.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 Other

All Presentation (3 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Presentation] 光音響分光法に基づく非侵襲血糖値計測における独立成分分析を用いた雑音抑制に関する研究2017

    • Author(s)
      橘康平、石原康利
    • Organizer
      日本設計工学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Optimization of I-shaped Cell for Noninvasive Blood Glucose Measurement based on Photoacoustic Spectroscopy2016

    • Author(s)
      K. Okada, K. Tachibana, R. Kobayashi, and Y. Ishihara
    • Organizer
      38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Orlando
    • Year and Date
      2016-08-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a High-Sensitivity and Portable Cell Using Helmholtz Resonance for Noninvasive Blood Glucose-Level Measurement Based on Photoacoustic Spectroscopy2016

    • Author(s)
      K. Tachibana, K. Okada, R. Kobayashi, and Y. Ishihara
    • Organizer
      38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Orlando
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] 計測工学研究室(石原研) 明治大学理工学部

    • URL

      http://www.isc.meiji.ac.jp/~insteng/

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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