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Measurements of vagal nerve activity by using in vivo two-photon imaging and MEMS electric recording

Research Project

Project/Area Number 16K12889
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Kamiya Atsunori  国立研究開発法人国立循環器病研究センター, 研究所, 循環モデル解析研究室長 (30324370)

Co-Investigator(Renkei-kenkyūsha) SUGIMACHI MASARU  国立研究開発法人国立循環器病センター研究所, 部長 (40250261)
KAZUTO KOBAYASHI  公立大学法人福島県立医科大学, 生体情報伝達研究所生体機能研究部門, 教授 (90211903)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords自律神経 / 迷走神経 / イメージング / 生理学
Outline of Final Research Achievements

Autonomic nervous system senses various biosignal by afferent (sensory) nerve fibers locating at whole body and regulate individual organs by efferent nerve fibers, and thus is one of key mechanisms that organize multiple organs functionally and maintain homeostasis (i.e., circulation, respiration, energy metabolism, thermoregulation) and life. However, because of less-developed technology for measurement of nerve activity, autonomic nerve activity is unclear except limited organs and nerve-types. In this study, we have recorded vagal nerve activity that has been known as difficult to be measured, and also did intra-organ vagal nerve activity that has never been measured.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Sodium ion transport participates in non-neuronal acetylcholine release in the renal cortex of anesthetized rabbits.2016

    • Author(s)
      Shimizu S, Akiyama T, Kawada T, Sata Y, Turner MJ, Fukumitsu M, Yamamoto H, Kamiya A, Shishido T, Sugimachi M.
    • Journal Title

      J Physiol Sci.

      Volume: 31 Issue: 5 Pages: 165-173

    • DOI

      10.1007/s12576-016-0489-5

    • NAID

      40021302055

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] In vivo imaging of cellular dynamics in physiology2017

    • Author(s)
      Kamiya A
    • Organizer
      the 44th Annual Meeting, Fatal and Neonatal Physiological Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 臓器内部における末梢神経のメカノセンシング動態2017

    • Author(s)
      神谷厚範
    • Organizer
      第56回日本生物物理学
    • Related Report
      2017 Annual Research Report
    • Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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