Development of a self-deploying and injectable drug release sheet
Project/Area Number |
16K12890
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Tohoku University |
Principal Investigator |
Kaji Hirokazu 東北大学, 工学研究科, 准教授 (70431525)
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Co-Investigator(Kenkyū-buntansha) |
阿部 俊明 東北大学, 医学系研究科, 教授 (90191858)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 薬物送達システム |
Outline of Final Research Achievements |
A sheet-type device capable of self-deployment and sustained release of protein type drugs. The device consisted of a thin photopolymerized polyethylene glycol dimethacrylate (PEGDM) sheet and collagen microparticles (COLs), which were embedded in the sheet as drug carriers and for increased drug permeation. Since protein type drugs electrostatically interacted with the COLs, a prolonged sustained release was possible. The PEGDM/COLs device was flexible enough to be rolled up. When the device was immersed in water, the attractive forces acting between the sheet surfaces were relieved by water. Subsequently, the device unfolded by bending-stress relaxation. Moreover, the rolled-up device could be injected through a conventional syringe needle into water to recover its original shape. The developed sheet-type device provides the possibility of minimally invasive transplantation into diseased tissues, and could provide better therapeutic outcomes and reduce possible side effects.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Long-term Protection of Genetically-Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery2017
Author(s)
Nobuhiro Nagai, Eri Koyanagi, Yasuko Izumida, Junjun Liu, Aya Katsuyama, Hirokazu Kaji, Matsuhiko Nishizawa, Noriko Osumi, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toru Nakazawa, Toshiaki Abe
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Journal Title
Investigative Ophthalmology & Visual Science
Volume: 57(15)
Issue: 15
Pages: 6527-6538
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 自己展開型薬剤徐放シートの網膜疾患治療への応用2016
Author(s)
近藤太郎, Zhaleh Kashkouli Nezhad, 陳俐君, 鈴木 仁, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
Organizer
日本バイオマテリアル学会シンポジウム2016
Place of Presentation
福岡国際会議場
Year and Date
2016-11-21
Related Report
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[Presentation] 自己展開型薬剤徐放シートの眼科領域への応用2016
Author(s)
近藤太郎, Zhaleh Kashkouli Nezhad, 陳俐君, 鈴木 仁, 永井展裕, 西澤松彦, 阿部俊明, 梶 弘和
Organizer
第32回日本DDS学会学術集会
Place of Presentation
静岡
Year and Date
2016-06-30
Related Report
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