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Role of brain-derived neurotrophic factor expression in peripheral tissues

Research Project

Project/Area Number 16K12894
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTakasaki University of Health and Welfare (2017)
University of Toyama (2016)

Principal Investigator

Fukuchi Mamoru  高崎健康福祉大学, 薬学部, 准教授 (40432108)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsBDNF / 生体イメージング / 発光 / 脂肪組織 / ケラチノサイト / BDNF / ルシフェラーゼ / 発光イメージング / 高脂肪食
Outline of Final Research Achievements

Brain-derived neurotrophic factor (BDNF) is highly expressed in the CNS and contributes to expressing a variety of neural functions including memory consolidation. Here, using a novel transgenic mouse strain, termed BDNF-Luc mouse, I found that BDNF was also expressed in peripheral tissues such as skin (keratinocytes) and adipose tissue. Interestingly, BDNF expression in adipose tissue was robustly induced by high fat diet. The induction of BDNF in adipose tissue was well corresponded with the increase in body weight. These results suggested that BDNF expressed in adipose tissue would be related to pathological obesity and BDNF might be a therapeutic target for pathological obesity.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] In silico screening identified novel small-molecule antagonists of PAC1 receptor.2018

    • Author(s)
      Takasaki I, Watanabe A, Yokai M, Watanabe Y, Hayakawa, D, Nagashima, R, Fukuchi, M, Okada, T, Toyooka, N, Miyata, A, Gouda H, Kurihara T.
    • Journal Title

      J. Pharmacol. Exp. Ther.

      Volume: - Issue: 1 Pages: 1-8

    • DOI

      10.1124/jpet.117.245415

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualizing changes in brain-derived neurotrophic factor (BDNF) expression using bioluminescence imaging in living mice2017

    • Author(s)
      Fukuchi Mamoru、Izumi Hironori、Mori Hisashi、Kiyama Masahiro、Otsuka Satoshi、Maki Shojiro、Maehata Yosuke、Tabuchi Akiko、Tsuda Masaaki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 4949-4949

    • DOI

      10.1038/s41598-017-05297-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Convergence of neurotransmissions at synapse on IEG regulation in nucleus.2017

    • Author(s)
      Mamoru Fukuchi, Masaaki Tsuda
    • Journal Title

      Frontiers in Bioscience

      Volume: 22 Issue: 7 Pages: 1052-1072

    • DOI

      10.2741/4533

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 生物発光を利用したBDNF遺伝子発現変化の可視化および創薬への応用2018

    • Author(s)
      福地守
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Visualizing changes in brain-derived neurotrophic factor (BDNF) expression using bioluminescence imaging in living mice.2017

    • Author(s)
      Mamoru Fukuchi, Hironori Izumi, Hisashi Mori, Masahiro Kiyama, Satoshi Otsuka, Shojiro Maki, Yosuke Maehata, Akiko Tabuchi, Masaaki Tsuda
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生物発光を利用したBDNF遺伝子発現変化の計測.2017

    • Author(s)
      福地守, 和泉宏謙, 森寿, 木山正啓, 大塚智史, 牧昌次郎, 田渕明子, 津田正明
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Monitoring and visualizing changes in the expression of BDNF gene using bioluminescence imaging2016

    • Author(s)
      Mamoru Fukuchi, Hisashi Mori, Akiko Tabuchi, Masaaki Tsuda
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      SanDiego, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] BDNF-Lucマウスを利用したBDNF遺伝子発現変化の可視化およびBDNF遺伝子発現誘導剤の探索2016

    • Author(s)
      福地守、前畑陽祐、森寿、牧昌次郎、田渕明子、津田正明
    • Organizer
      第38回日本生物学的精神医学会 第59回日本神経化学会大会 合同大会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 生物発光イメージングを利用した生体マウスにおけるBDNF発現変化の可視化2016

    • Author(s)
      福地守、和泉宏謙、田中亜由美、井上蘭、森寿、牧昌次郎、木山正啓、大塚智史、前畑陽祐、津田正明
    • Organizer
      第39本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 神経可塑性の分子基盤を担う遺伝子発現制御系の解明2016

    • Author(s)
      福地守
    • Organizer
      日本薬学会北陸支部第128回例会
    • Place of Presentation
      金沢
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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