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Establishment of novel non-invasive therapy for siRNA-induced wound healing using sonoporation techniques, nano-size drug delivery systems

Research Project

Project/Area Number 16K12913
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical systems
Research InstitutionSaga University

Principal Investigator

Teramoto Noriyoshi  佐賀大学, 医学部, 教授 (40294912)

Co-Investigator(Kenkyū-buntansha) 山本 格士  佐賀大学, 医学部, 助教 (80762187)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords医用システム / 低侵襲治療システム / 血管新生学 / 核酸医薬 / ナノ医工学 / 核酸医薬品 / 核酸 / 薬理学
Outline of Final Research Achievements

The aim of the present research project is to establish a basal knowledge of novel non-invasive therapy for siRNA-induced wound healing using nano-size drug delivery systems (i.e. sonoporation techniques), which is designed to stimulate the collateral circulation in compromised tissues. This technique will also be applicable in not only rapid wound healing but also organ transplant and regenerative medicine. It is generally believed that this novel technique will contribute substantially to the extension of the national healthy life expectancy in Japan near future.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Effects of 4,9-anhydrotetrodotoxin on voltage-gated Na+ channels of mouse vas deferens myocytes and recombinant NaV1.6 channels.2018

    • Author(s)
      Takahara K, Yamamoto T, Uchida K, Zhu HL, Shibata A, Inai T, Noguchi M, Yotsu-Yamashita M, Teramoto N
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacology

      Volume: 391 Issue: 5 Pages: 489-499

    • DOI

      10.1007/s00210-018-1476-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ZD0947, a novel and potent ATP-sensitive K+ channel opener, on smooth muscle-type ATP-sensitive K+ channels.2016

    • Author(s)
      Mori K, Yamashita Y, Teramoto N
    • Journal Title

      European Journal of Pharmacology

      Volume: 791 Pages: 773-779

    • DOI

      10.1016/j.ejphar.2016.09.038

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] ZD0947投与によるマウス血管平滑筋型ATP感受性K+チャネルの活性化2017

    • Author(s)
      山本 格士、内田 啓一郎、高原 光平、寺本 憲功
    • Organizer
      日本薬理学会 年会
    • Place of Presentation
      長崎市
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] マウス輸精管平滑筋に発現している電位依存性ナトリウムチャネルにおよぼす4,9-AH-TTXの効果2017

    • Author(s)
      寺本 憲功、山本 格士、内田 啓一郎、稲井 哲一朗、山下 まり
    • Organizer
      日本薬理学会 年会
    • Place of Presentation
      長崎市
    • Related Report
      2016 Research-status Report
  • [Remarks] 佐賀大学医学部薬理学

    • URL

      http://www.pharmacology.med.saga-u.ac.jp/YAKURIHP/Top_Page.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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