| Project/Area Number |
16K12928
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 骨格筋 / 生体インピーダンス計測 / シミュレーション / 電気インピーダンス / 四端子計測 / インピーダンス / アドミッタンス / アドミタンス / 筋緊張 / 理学療法 |
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| Outline of Final Research Achievements |
As theoretical examinations, an unique technique of the finite-difference method using equivalent elements was developed to evaluate the electrical impedance of muscles, by taking account of the histological structure of the muscles, in which long tubular muscle cells are bundled. Additionally, a technique for representing the effects of the T-tubules in the calculations by analytical relations was developed. Theoretical analyses of reported experimental results using these techniques revealed the histological origin of the observed changes in the impedance of the muscles. The techniques were also utilized for preliminary examinations for experimental methods and analysis methods of experimental data.
As experimental examinations, the impedance of electric circuits consisting of capacitors and resistors were measured to examine whether measuring instruments could be used in the “four-terminal method” measurements in a wide frequency region.
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| Academic Significance and Societal Importance of the Research Achievements |
体表に電極を設置して交流電気インピーダンスを測定すると疾病等による骨格筋の変化が非侵襲的に検出できる、という多くの実験研究が報告されてきた。しかし、理論的基盤が脆弱で、計測結果の理論解析ができなかった。骨格筋は細長い細胞の束であるという組織学的特徴をもつ。このため、細胞長軸と平行方向の電気的性質は電極の位置によって変化し組織固有のパラメータで表すことができない。よって、従来の技法で骨格筋のインピーダンスを計算することは不合理である。本研究で開発した計算技法によって、骨格筋の組織学的特徴を取り入れ、かつ大きな筋モデルでも小さい計算負荷で電気インピーダンスの計算が実行できるようになった。
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