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Cerebral brain activity during walking in freely moving subjects

Research Project

Project/Area Number 16K12935
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHiroshima University

Principal Investigator

Matsukawa Kanji  広島大学, 医系科学研究科(保), 教授 (90165788)

Co-Investigator(Kenkyū-buntansha) 遠藤 加菜  広島大学, 医歯薬保健学研究科(保), 助教 (60584696)
梁 楠  京都大学, 医学研究科, 准教授 (70512515)
Research Collaborator Asahara Ryota  
Ishii Kei  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords大脳皮質脳活動 / 無拘束歩行運動 / 携帯型近赤外分光計 / 中枢コマンド / リハビリテーション / 大脳皮質前頭前野 / 大脳皮質運動野 / セントラルコマンド
Outline of Final Research Achievements

To directly visualize cerebral activity during overground walking in daily life, we have developed a new wireless recording system of brain activity using wearable near-infrared spectroscopy (NIRS) in freely moving human subjects. Concentration of oxygenated hemoglobin (Oxy-Hb) was measured as an index of regional cerebral blood flow. The Oxy-Hb of the prefrontal cortex (especially the frontopolar and dorsolateral prefrontal areas) increased by 5-10 sec prior to the onset of walking, whereas the Oxy-Hb of the motor cortex did not change preceding walking. It is suggested that the prefrontal cortex has relation to generation of central command responsible for circulatory adjustment at the onset of exercise in daily life.

Academic Significance and Societal Importance of the Research Achievements

本研究は日常時の歩行運動中にみられるヒト皮質前頭前野や運動野の脳活動を計測できる方法を新たに開発した。この脳活動計測系を健常者のみならず高齢者や運動失調者に応用することは可能である。新たな研究成果として前頭前野の活動は歩行開始に5秒以上先行して増加することを発見した。この成果は前頭前野が運動時の循環調節を担う中枢コマンドの発現と関わることを示唆するという学術的な意義を持つ。このような新しい計測系や学問的な成果をリハビリテーションの臨床現場につなげ、高齢者や運動失調者の運動機能や循環調節能の変容を科学的に把握することでEvidence-basedなリハビリテーション医療に貢献できると思われる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (43 results)

All 2019 2018 2017 2016 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results,  Open Access: 3 results,  Acknowledgement Compliant: 4 results) Presentation (25 results) (of which Int'l Joint Research: 10 results,  Invited: 3 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Deactivation of the prefrontal cortex during exposure to pleasantly-charged emotional challenge2018

    • Author(s)
      Matsukawa Kanji、Asahara Ryota、Yoshikawa Miho、Endo Kana
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 14540-14540

    • DOI

      10.1038/s41598-018-32752-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Feedforward- and motor effort-dependent increase in prefrontal oxygenation during voluntary one-armed cranking2018

    • Author(s)
      Ishii K, Liang N, Asahara R, Takahashi M, Matsukawa K
    • Journal Title

      J Physiol

      Volume: 596 Issue: 21 Pages: 5099-5118

    • DOI

      10.1113/jp276956

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An increase in prefrontal oxygenation at the start of voluntary cycling exercise was observed independently of exercise effort and muscle mass2018

    • Author(s)
      Asahara Ryota、Endo Kana、Liang Nan、Matsukawa Kanji
    • Journal Title

      European Journal of Applied Physiology

      Volume: 118 Issue: 8 Pages: 1689-1702

    • DOI

      10.1007/s00421-018-3901-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased prefrontal oxygenation elicited by stimulation of limb mechanosensitive afferents during cycling exercise2018

    • Author(s)
      Asahara Ryota、Matsukawa Kanji
    • Journal Title

      American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

      Volume: 印刷中 Issue: 2 Pages: R230-R240

    • DOI

      10.1152/ajpregu.00454.2017

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Incremental rate of prefrontal oxygenation determines performance speed during cognitive Stroop test: the effect of ageing2018

    • Author(s)
      Endo Kana、Liang Nan、Idesako Mitsuhiro、Ishii Kei、Matsukawa Kanji
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 印刷中 Issue: 6 Pages: 807-824

    • DOI

      10.1007/s12576-018-0599-3

    • NAID

      40021720582

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] セントラルコマンドによる見込み制御2018

    • Author(s)
      松川寛二、浅原亮太、石井圭
    • Journal Title

      体育の科学

      Volume: 68 Pages: 636-643

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Prefrontal oxygenation correlates to the responses in facial skin blood flows during exposure to pleasantly charged movie2017

    • Author(s)
      Matsukawa Kanji、Endo Kana、Asahara Ryota、Yoshikawa Miho、Kusunoki Shinya、Ishida Tomoko
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 21

    • DOI

      10.14814/phy2.13488

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central command increases muscular oxygenation of the non-exercising arm at the early period of voluntary one-armed cranking2017

    • Author(s)
      Ishii K, Matsukawa K, Asahara R, Liang N, Endo K, Idesako M, Michioka K, Sasaki Y, Hamada H, Yamashita K, Watanabe T, Kataoka T, Takahashi M
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 7 Pages: 1-18

    • DOI

      10.14814/phy2.13237

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Facial skin blood flow responses to exposures to emotionally charged movies2017

    • Author(s)
      Matsukawa K, Endo K, Ishii K, Ito M, Liang N
    • Journal Title

      Journal of Physiological Sciences

      Volume: 印刷中 Issue: 2 Pages: 1-16

    • DOI

      10.1007/s12576-017-0522-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Central command does not supress baroreflex control of cardiac sympathetic nerve activity at the onset of spontaneous motor activity in the decerebrate cat2016

    • Author(s)
      Matsukawa K, Ishii K, Asahara R, Idesako M
    • Journal Title

      Journal of Applied Physiology

      Volume: 121 Issue: 4 Pages: 932-943

    • DOI

      10.1152/japplphysiol.00299.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The prefrontal oxygenation and ventilatory responses at start of one-legged cycling exercise have relation to central command2016

    • Author(s)
      Asahara R, Matsukawa K, Ishii K, Liang N, Endo K
    • Journal Title

      Journal of Applied Physiology

      Volume: 121 Issue: 5 Pages: 1115-1126

    • DOI

      10.1152/japplphysiol.00401.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Central command generated prior to arbitrary motor execution induces muscle vasodilatation at the beginning of dynamic exercise.2016

    • Author(s)
      Ishii K, Matsukawa K, Liang N, Endo K, Idesako M, Asahara R, Kadowaki A, Wakasugi R, Takahashi M
    • Journal Title

      J Appl Physiol

      Volume: 21 Issue: 12 Pages: 1424-1433

    • DOI

      10.1152/japplphysiol.00103.2016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] S12-5: Modulation of cardiac baroreflex by central command in daily life2019

    • Author(s)
      Matsukawa K, Ishii K, Asahara R
    • Organizer
      The 9th Federation of the Asian and Oseanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Contribution of the rostroventral midbrain to movement-related cardiovascular activation2019

    • Author(s)
      Ishii K, Asahara R, Liang N, Komine H, Matsukawa K
    • Organizer
      The 9th Federation of the Asian and Oseanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differential improvement of performance by motor imagery of human ankle dorsal and plantar flexion2019

    • Author(s)
      Liang N, Tsubota A, Mukai M, Takezawa A, Masuhara T, Matsukawa K
    • Organizer
      The 9th Federation of the Asian and Oseanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Central command increases oxygenation of the non-contracting arm muscles during fine hand movement2019

    • Author(s)
      Asahara R, Matsukawa K, Ishii K, Okamoto I, Sunami Y, Hamada H, Kataoka T, Ohshita W, Watanabe T
    • Organizer
      The 9th Federation of the Asian and Oseanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Atrioventricular nodal function during dynamic exercise in elite endurance athletes2019

    • Author(s)
      Takahashi M, Nakamoto T, Niihata S, Matsukawa K
    • Organizer
      The 9th Federation of the Asian and Oseanian Physiological Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A limb mechanoreflex decreases the prefrontal oxygenation during motor-driven passive cycling in humans.2018

    • Author(s)
      Asahara R, Hashiguchi Y, Matsukawa K.
    • Organizer
      第95回日本生理学会大会, 高松市, 2018年3月.
    • Related Report
      2017 Research-status Report
  • [Presentation] Feedforward control of the cardiovascular system during exercise: insight from animal and human studies.2018

    • Author(s)
      Asahara R, Matsukawa K.
    • Organizer
      第95回日本生理学会大会, 高松市, 2018年3月.
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Responses in facial skin blood flow and prefrontal oxygenation during exposure to emotionally charged negative and positive odors.2018

    • Author(s)
      Endo K, Yoshikawa M, Matsukawa K, Nakamura A, Nakamura T.
    • Organizer
      第95回日本生理学会大会, 高松市, 2018年3月.
    • Related Report
      2017 Research-status Report
  • [Presentation] Changes in human prefrontal activity during exposure to emotionally-charged movies: a preliminary study by simultaneous recordings of NIRS and fMRI.2018

    • Author(s)
      Liang N, Harada T, Sasaoka T, Yamawaki S, Endo K, Matsukawa K.
    • Organizer
      第95回日本生理学会大会, 高松市, 2018年3月.
    • Related Report
      2017 Research-status Report
  • [Presentation] Prefrontal oxygenation correlates to the responses in facial skin blood flows during exposure to pleasantly-charged movie.2018

    • Author(s)
      Matsukawa K, Endo K, Yoshikawa M, Asahara R.
    • Organizer
      第95回日本生理学会大会, 高松市, 2018年3月.
    • Related Report
      2017 Research-status Report
  • [Presentation] Symposium 9: Increased oxygenation of the prefrontal cortex prior to the onset of exercise has relation to central command2017

    • Author(s)
      Matsukawa K, Ishii K, Asahara R, Endo K, Liang N
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] The cerebral prefrontal oxygenation during first and third person imagery of cycling exercise2017

    • Author(s)
      Liang N, Arikawa M, Satake Y, Endo K, Asahara R, Matsukawa K
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Effect of motor imagery on blood flow in leg skeletal muscle in elderly subjects2017

    • Author(s)
      Endo K, Ishii K, Asahara R, Doi S, Liang N, Matsukawa K
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Increased oxygenation of the dorsolateral prefrontal cortex prior to the onset of voluntary one-armed cranking2017

    • Author(s)
      Ishii K, Matsukawa K, Liang N
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Effect of endurance training on the centrally-induced muscle vasodilatation during one-legged cycling2017

    • Author(s)
      Asahara R, Matsukawa K, Shintaku T
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Effect of endurance training on the centrally-induced muscle vasodilatation during one-legged cycling.2017

    • Author(s)
      Asahara R, Matsukawa K, Shintaku T.
    • Organizer
      Experimental Biology 2017, Chicago, USA, 22-26 April, 2017.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Facial skin blood flow decreases during exposure to pleasantly charged movie in humans.2017

    • Author(s)
      Asahara R, Endo K, Yoshikawa M, Kusunoki S, Matsukawa K.
    • Organizer
      The International Society for Autonomic Neuroscience 2017, Aichi, Japan, 30 August - 2 September, 2017.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reduction in prefrontal oxygenation during exposure to positively-charged emotional movie in humans.2017

    • Author(s)
      Endo K, Yoshikawa M, Kusunoki S, Asahara R, Matsukawa K.
    • Organizer
      The International Society for Autonomic Neuroscience 2017, Aichi, Japan, 30 August - 2 September, 2017.
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 自発運動開始時における前頭前野の酸素化ヘモグロビン濃度の増加は運動強度と比例しない.2017

    • Author(s)
      浅原 亮太, 松川 寛二, 梁 楠, 遠藤 加菜.
    • Organizer
      第72回日本体力医学大会, 松山市, 2017年9月.
    • Related Report
      2017 Research-status Report
  • [Presentation] ラット皮質前頭前野の電気刺激は副交感神経を介する口唇領域の血管拡張を引き起こす.2017

    • Author(s)
      浅原 亮太, 松川 寛二.
    • Organizer
      第69回日本生理学会中国四国地方会, 徳島市, 2017年10月.
    • Related Report
      2017 Research-status Report
  • [Presentation] 快感情の映像刺激は皮質前頭前野の酸素化ヘモグロビン濃度を減少させる.2017

    • Author(s)
      松川 寛二, 遠藤 加菜, 吉川 美穂, 浅原 亮太, 楠 信哉.
    • Organizer
      第69回日本生理学会中国四国地方会, 徳島市, 2017年10月.
    • Related Report
      2017 Research-status Report
  • [Presentation] 嗅覚刺激による快・不快の情動変化が顔面皮膚血流量および前頭葉ヘモグロビン動態に与える影響2017

    • Author(s)
      遠藤 加菜, 吉川 美穂, 松川 寛二, 中村 明朗, 中村 哲也
    • Organizer
      第51回日本味と匂学会, 神戸市, 2017年9月.
    • Related Report
      2017 Research-status Report
  • [Presentation] Central commnad hypothesis: from cerebral prefrontal cortex to blood vessels of skeletal muscle2016

    • Author(s)
      Matsukawa K
    • Organizer
      The 6th International Sports Science Network Forum in Nagano 2016
    • Place of Presentation
      松本市
    • Year and Date
      2016-11-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The prefrontal oxygenation at the onset of unrestrained overground walking in humans2016

    • Author(s)
      Asahara R, Matsukawa K, Liang N, Endo K, Ishii K
    • Organizer
      The 6th International Sports Science Network Forum in Nagano 2016
    • Place of Presentation
      松本市
    • Year and Date
      2016-11-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 運動開始時における前頭前野酸素化ヘモグロビン濃度の増加と換気応答の関連2016

    • Author(s)
      浅原亮太、松川寛二、石井圭、梁楠、遠藤加菜
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      盛岡市
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Book] 解剖学・生理学・運動学に基づく動作分析2018

    • Author(s)
      松川寛二
    • Total Pages
      47
    • Publisher
      医歯薬出版
    • Related Report
      2018 Annual Research Report
  • [Book] 解剖学・生理学・運動学に基づく動作分析: 第1章 2. 生理学の概要2018

    • Author(s)
      松川寛二
    • Total Pages
      47
    • Publisher
      医歯薬出版株式会社
    • ISBN
      9784263265505
    • Related Report
      2017 Research-status Report
  • [Book] 生理学: 第5章 筋肉・運動の生理2016

    • Author(s)
      松川寛二
    • Total Pages
      26
    • Publisher
      理工図書(株)
    • Related Report
      2016 Research-status Report
  • [Remarks] 広島大学医学部保健学科・生理機能情報科学研究室のオリジナルホームページ

    • URL

      http://home.hiroshima-u.ac.jp/matsulab/

    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Remarks] 広島大学医学部・生理機能情報科学研究室

    • URL

      http://home.hiroshima-u.ac.jp/med/research/lab/health/Integrative_Physiology

    • Related Report
      2017 Research-status Report
  • [Remarks] 広島大学医学部・生理機能情報科学研究室

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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