| Project/Area Number |
16K13018
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KITA Ichiro 首都大学東京, 大学院人間健康科学研究科, 教授 (10186223)
FUJII Nobuharu 首都大学東京, 大学院人間健康科学研究科, 教授 (40509296)
TAKENAKA Asako 明治大学, 農学部, 教授 (40231401)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 海馬 / 神経新生 / 活性酸素種 / 抗酸化物質 / 活性酸素 / 運動 |
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| Outline of Final Research Achievements |
This study tested a hypothesis that positive effects of exercise on the hippocampal plasticity is mediated by reactive oxygen species (ROS) signaling, and antioxidant supplementation could suppress the positive effects of exercise. Male C57BL/6J mice performed voluntary wheel running for 4 weeks with or without antioxidants (vitamin C and D) supplementation. We found that exercise increased the hippocampal neurogenesis (densities of Ki-67-ir cells, and Doublecortin-ir cells), which were suppressed by vitamin C and D in a dose-dependent manner. These results suggest that the exercise-induced neurogenesis is regulated, at least in part, through ROS signaling, although further study is warranted to unveil the underlying molecular mechanisms.
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