| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Regular exercise increases capillary density in skeletal muscle. Regular exercise contributes to ameliorate in the early stage of peripheral arterial disease (PAD). Increased capillary density is one of the mechanisms to prevent PAD by regular exercise. In the current study, we hypothesized that regular exercise-induced muscle-derived chemokine contribute to promote angiogenesis in skeletal muscle. In this study, we have demonstrated that enhanced contractile activity induces the chemokine both in vivo and in vitro demonstrating that the chemokine is secreted from muscle. However, our findings in muscle-specific the chemokine knockout mice indicate that muscle-derived the chemokine is not necessary for exercise training-induced angiogenesis in skeletal muscle.
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