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Potential increase in erythropoietin to hypoxic exposure after exercise in the heat

Research Project

Project/Area Number 16K13020
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionOsaka City University

Principal Investigator

Okazaki Kazunobu  大阪市立大学, 都市健康・スポーツ研究センター, 教授 (70447754)

Co-Investigator(Kenkyū-buntansha) 後藤 一成  立命館大学, スポーツ健康科学部, 教授 (60508258)
Co-Investigator(Renkei-kenkyūsha) YOKOYAMA Hisayo  大阪市立大学, 都市健康・スポーツ研究センター, 准教授 (10647829)
IMAI Daiki  大阪市立大学, 都市健康・スポーツ研究センター, 講師 (40614483)
Research Collaborator TAKEDA Ryosuke  
KAWAI Eriko  
OTA Akemi  
SUZUKI Yuta  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords低酸素 / 暑熱 / 血漿量 / 赤血球 / ヘモグロビン / 暑熱環境 / 低酸素環境 / 運動トレーニング / 赤血球量 / EPO
Outline of Final Research Achievements

We tested the hypothesis that erythropoietin release to hypoxic exposure was enhanced with an increased plasma volume after exercise in the heat. In young subjects, a bout of intense exercise (72 min) was performed in a warm (30 deg C) and a cool (20 deg C) environmental condition. After 23 hours, they were exposed to hypoxia (oxygen concentration 14.4%) for 3 hours. Plasma volume was increased more in the heat than in the cool condition after 23 hours of exercise. More importantly, EPO release to the 3 hours hypoxic exposure was enhanced in the heat compared to the cool condition. Next, in young subjects, the effects of exercise-hypoxic exposure for 5 consecutive days was compared between exercise in the heat and in the cool conditions. Plasma volume but not red cell volume was increased more in the heat than in the cool condition after 5 days of training.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (26 results)

All 2018 2017 2016

All Journal Article (8 results) (of which Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (14 results) (of which Int'l Joint Research: 7 results,  Invited: 5 results) Book (3 results) Funded Workshop (1 results)

  • [Journal Article] Body Temperature Regulation During Exercise and Hyperthermia in Diabetics2018

    • Author(s)
      Takeda R, Okazaki K
    • Journal Title

      InTechOpen - Diabetes

      Volume: - Pages: 89-108

    • DOI

      10.5772/intechopen.74063

    • ISBN
      9781789230345, 9781789230352
    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020772

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of skin surface cooling before exercise on lactate accumulation in cool environment2018

    • Author(s)
      Imai D, Takeda R, Suzuki A, Naghavi N, Yamashina Y, Matsumura S, Yokoyama H, Miyagawa T, Okazaki K
    • Journal Title

      European Journal of applied Physiology

      Volume: 118 Issue: 3 Pages: 551-562

    • DOI

      10.1007/s00421-017-3797-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of stimulation of odor of essential oil on muscle sympathetic nervous activity2017

    • Author(s)
      Kawai E, Hanno G, Takeda R, Ota A, Morita E, Imai D, Suzuki Y, Yokoyama H, Okazaki K
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 6 Pages: 447-447

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Effects of a 3-month walking training on thermal sensation in healthy elderly men2017

    • Author(s)
      Takeda R, Imai D, Ota A, Kawai E, Hanno G, Naghavi N, Morita E, Suzuki Y, Yokoyama H, Okazaki K
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 6 Pages: 497-497

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Body temperature regulation during exercise training2016

    • Author(s)
      Takeda R, Imai D, Suzuki A, Ota A, Naghavi N, Yamashina Y, Hirasawa Y, Yokoyama H, Miyagawa T, Okazaki K
    • Journal Title

      Int J Biometeorol

      Volume: 60 Pages: 1925-1932

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lower thermal sensation in normothermic and mildly hyperthermic older adults2016

    • Author(s)
      Takeda R, Imai D, Suzuki A, Ota A, Naghavi N, Yamashina Y, Hirasawa Y, Yokoyama H, Miyagawa T, Okazaki K
    • Journal Title

      Eur J Appl Physiol

      Volume: 116 Issue: 5 Pages: 975-984

    • DOI

      10.1007/s00421-016-3364-4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Forced respiration during the deeper water immersion causes the greater inspiratory muscle fatigue in healthy young men2016

    • Author(s)
      Yamashina Y, Yokoyama H, Naghavi N, Hirasawa Y, Takeda R, Ota A, Imai D, Miyagawa T, Okazaki K
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 28 Issue: 2 Pages: 412-418

    • DOI

      10.1589/jpts.28.412

    • NAID

      130005127387

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treadmill walking in water induces greater respiratory muscle fatigue than treadmill walking on land in healthy young men2016

    • Author(s)
      Yamashina Y, Yokoyama H, Naghavi N, Hirasawa Y, Takeda R, Ota A, Imai D, Miyagawa T, Okazaki K
    • Journal Title

      J Physiol Sci

      Volume: 66 Issue: 3 Pages: 257-264

    • DOI

      10.1007/s12576-015-0423-2

    • NAID

      120006523111

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020530

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Exercise in a warm condition enhances plasma volume expansion compared to a cool condition with an increased skin but not core temperature2018

    • Author(s)
      Okazaki K, Takeda R, Imai D, Kawai E, Ota A, Hanno G, Morita E, Yokoyama H
    • Organizer
      Experimental Biology 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effects of core and skin temperatures and dehydration on heart rate response during interval exercise in warm and cool conditions2018

    • Author(s)
      Takeda R, Imai D, Kawai E, Ota A, Hanno G, Morita E, Suzuki Y, Yokoyama H, Okazaki K
    • Organizer
      Experimental Biology 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Confounding factors for the erythropoietic response to altitude training2017

    • Author(s)
      Okazaki K
    • Organizer
      High altitude training/hypoxic training Symposium in Beijing Sports University
    • Place of Presentation
      中国(北京)
    • Year and Date
      2017-05-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Effects of carbohydrate in beverage on thermoregulatory responses2017

    • Author(s)
      Okazaki K
    • Organizer
      ARIHHP Human High Performance International Forum 2017
    • Place of Presentation
      茨城県つくば市
    • Year and Date
      2017-03-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Rio 2016: Altitude Training in Preparation for Podium Performance2017

    • Author(s)
      Okazaki K
    • Organizer
      第20回高所トレーニング国際シンポジウム in Tomi
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Effects of odor stimulation with essential oil on muscle sympathetic nerves activity in humans2017

    • Author(s)
      Kawai E, Hanno G, Takeda R, Ota A, Morita E, Imai D, Suzuki Y, Yokoyama H, Okazaki K
    • Organizer
      The 17th International Conference on Environmental Ergonomics ICEE 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Whole body and skin termal sensation are not improved with regular exercise in elderly men2017

    • Author(s)
      Takeda R, Imai D, Ota A, Kawai E, Hanno G, Naghavi N, Morita E, Suzuki Y, Yokoyama H, Okazaki K
    • Organizer
      The 17th International Conference on Environmental Ergonomics ICEE 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 定期的運動の実施が高齢者の温度感覚に及ぼす影響2017

    • Author(s)
      竹田良祐,今井大喜,太田暁美,河合英里子,半野源太,Naghavi Nooshin,森田恵美子,鈴木雄太,横山久代,岡﨑和伸
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 精油の臭い刺激が筋交感神経活動に及ぼす影響2017

    • Author(s)
      河合英里子,半野源太,竹田良祐,太田暁美,森田恵美子,今井大喜,鈴木雄太,横山久代,岡﨑和伸
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A 3-month walking training does not improve thermal sensation in healthy elderly men2017

    • Author(s)
      Takeda R, Imai D, Ota A, Kawai E, Hanno G, Naghavi N, Morita E, Suzuki Y, Yokoyama H, Okazaki K
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Change in blood pressure by inhalation of fragrance of essential oil and muscle sympathetic nerve activity2017

    • Author(s)
      Kawai E, Hanno G, Takeda R, Ota A, Morita E, Imai D, Suzuki Y, Yokoyama H, Okazaki K
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Thermoregulatory responses are enhanced by insulin delivery to brain by intranasal insulin administration in humans2016

    • Author(s)
      Okazaki K, Takeda R, Imai D, Ota A, Naghavi N, Kawai E, Hanno G, Yokoyama H, Miyagawa T
    • Organizer
      The 6th International Conference on the Physiology and Pharmacology of Temperature Regulation
    • Place of Presentation
      スロベニア(リュブリャナ)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 低圧低酸素に対する循環系の応答と順化, シンポジウム16 高地/低酸素トレーニングの根拠と現状に基づき今後の方向性を探る2016

    • Author(s)
      岡崎和伸
    • Organizer
      第27回日本臨床スポーツ医学会
    • Place of Presentation
      千葉県千葉市
    • Year and Date
      2016-11-06
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 暑熱環境に対する生体応答の個体差2016

    • Author(s)
      岡崎和伸
    • Organizer
      第29回運動と体温の研究会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2016-09-22
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] 子どもの暑さや寒さに対応する能力は,大人と同じ?.もっとなっとく使えるスポーツサイエンス2017

    • Author(s)
      岡崎和伸
    • Total Pages
      3
    • Publisher
      講談社サイエンティフィク
    • Related Report
      2016 Research-status Report
  • [Book] 暑さや寒さに対応する能力は,老化によって衰える?.もっとなっとく使えるスポーツサイエンス2017

    • Author(s)
      岡崎和伸
    • Total Pages
      3
    • Publisher
      講談社サイエンティフィク
    • Related Report
      2016 Research-status Report
  • [Book] Body temperature regulation during exercise training2016

    • Author(s)
      Okazaki K
    • Total Pages
      15
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report
  • [Funded Workshop] The 6th International Conference on the Physiology and Pharmacology of Temperature Regulation2016

    • Place of Presentation
      スロベニア(リュブリャナ)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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