| Project/Area Number |
16K13022
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Toyohashi Sozo University |
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Principal Investigator |
GOTO Katsumasa 豊橋創造大学, 保健医療学部, 教授 (70239961)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNO Yoshitaka 豊橋創造大学, 保健医療学部, 講師 (80440808)
YOKOYAMA Shingo 豊橋創造大学, 保健医療学部, 助教 (30706859)
EGAWA Tatsuro 豊橋創造大学, 大学院健康科学研究科, 協力研究員 (00722331)
NAGATOMI Ryoichi 東北大学, 大学院医工学研究科, 教授 (20208028)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 骨格筋 / adiponectin / C2C12 / 筋萎縮 / 加齢 / 速筋 / アディポネクチン / 萎縮 / 速筋細胞 |
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| Outline of Final Research Achievements |
the purpose of this study was to investigate the effects of high-level adiponectin on skeletal muscle mass. High concentration of adiponectin receptor agonist AdipoRon suppressed myogenic differentiation of C2C12 cells in a dose-dependent manner. Repetitive administration of AdipoRon caused to decrease in muscle wet weight of fast-type plantaris, but not of slo-type soleus, in mice. Evidences from this study suggest that high blood-level adiponectin may be a cause of aging-associated skeletal muscle atrophy, so-called sarcopenia,that exhibits fast muscle-specific skeletal muscle atrophy.
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