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Whether reduction of skeletal muscle function causes deterioration of cognitive function or depression symptoms

Research Project

Project/Area Number 16K13047
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionUniversity of Shizuoka

Principal Investigator

Miura Shinji  静岡県立大学, 食品栄養科学部, 教授 (10342932)

Co-Investigator(Kenkyū-buntansha) 守田 昭仁  静岡県立大学, 食品栄養科学部, 助教 (40239653)
Co-Investigator(Renkei-kenkyūsha) KAMEI YASUTOMI  京都府立大学, 生命環境科学研究科, 教授 (70300829)
ASAI AKIRA  静岡県立大学, 大学院 薬学研究科, 教授 (60381737)
UNNO KEIKO  静岡県立大学, 薬学部, 准教授 (10106437)
YOSHIDA TAKUYA  静岡県立大学, 食品栄養科学部, 助教 (80622448)
Research Collaborator SATO TOMOKI  静岡県立大学, 大学院 薬食生命科学総合学府
SENOO NANAMI  静岡県立大学, 大学院 薬食生命科学総合学府
ISHINO MAYU  静岡県立大学, 大学院 薬食生命科学総合学府
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords加齢 / 老化 / 筋萎縮 / 認知機能 / うつ / ストレス / キヌレニン / キヌレン酸 / 加齢・老化
Outline of Final Research Achievements

Kynurenine is produced peripherally by stress exposure and causes depression symptoms in the brain. It was reported that exercise increases KAT expression in skeletal muscle, promotes degradation of kynurenine in the periphery and suppresses stress induced-depression. Therefore, in this study, we examined the hypothesis that "if the skeletal muscle function declines due to inactivity, the degradation of kynurenine is decreased, kynurenine influx into the brain is accelerated, and depressive symptoms worsen". As a result, even if the expression level of KAT of skeletal muscle was decreased, there was little effect on depressive symptoms. Any change in expression level of KAT was not observed in skeletal muscle of muscle atrophy model mouse (FOXO 1 Tg mouse). Injection of kynurenine into FOXO 1 Tg mouse caused no adverse effect on the expression level of hippocampal depression related genes.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2017

All Presentation (5 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Presentation] KIS-154, a FOXO1 inhibitor, is one of the candidate compounds to prevent skeletal muscle atrophy.2017

    • Author(s)
      Watanabe, Y., Nakagawa, T., Morita, A., Ogo, N., Asai, A., Kamei, Y., and Miura, S.
    • Organizer
      The 22nd Shizuoka Forum on Health and Longevity
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨格筋の機能低下がキヌレニン代謝および「うつ」症状に与える影響2017

    • Author(s)
      石野真悠、守田昭仁、三浦進司
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 絶食後の骨格筋におけるリン脂質組成変化とFOXO1の関与2017

    • Author(s)
      妹尾奈波、三好規之、守田昭仁、亀井康富、三浦進司
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Foxo1を標的とした筋萎縮抑制化合物の探索2017

    • Author(s)
      渡辺優衣、中川匠、守田昭仁、小郷尚久、浅井章良、亀井康富、三浦進司
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨格筋機能低下によるうつ症状への影響2017

    • Author(s)
      石野真悠、三浦進司
    • Organizer
      第5回骨格筋生物学研究会
    • Related Report
      2017 Annual Research Report
  • [Book] 非栄養素の分子栄養学2017

    • Author(s)
      畑澤幸乃、三浦進司、亀井康富
    • Total Pages
      251
    • Publisher
      建帛社
    • ISBN
      9784767961897
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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