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Mechanisms involved in heat tolerance due to depletion of estradiol secretion

Research Project

Project/Area Number 16K13055
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionWaseda University

Principal Investigator

Nagashima Kei  早稲田大学, 人間科学学術院, 教授 (40275194)

Co-Investigator(Kenkyū-buntansha) 森本 恵子  奈良女子大学, 生活環境科学系, 教授 (30220081)
内田 有希  奈良女子大学, 生活環境科学系, 助教 (50634002)
Research Collaborator Marui Shuri  早稲田大学, 人間科学学研究科
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords行動性体温調節 / 尾隠し行動 / 卵巣摘出 / 温度感覚 / TRP / 視床下部 / 熱放散 / FOS / 女性ホルモン / 暑熱順化 / 体温調節 / ラット / マウス / 温度受容 / 更年期 / エストロゲン / 女性 / 熱中症 / 日内リズム / 体温 / 行動
Outline of Final Research Achievements

The present research aimed, (1) to develop a mouse model for evaluating the thermal tolerance of postmenopausal women, ② to test if decrease of estradiol secretion augments a risk of heat stroke (autonomic reaction, behavioral reaction, temperature sensation, cognitive function and behavior related to the heat), and it affects time dependence or not. We completed a system to evaluate the heat escape behaviors of mice and at the same time evaluated metabolic rate under heat. Estradiol contributed to the decrease in metabolic rate at the time of heat loading, and it seemed that this decrease is related to the decrease of the heat resistance. Also, its effect was noticeable in the light period. It was thought that the heat escape behavior was not affected.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Regional differences of cFos immunoreactive cells in the preoptic areas in hypothalamus associated with heat and cold responses in mice2018

    • Author(s)
      Yuki Uchida, Keisuke Onishi, Ken Tokizawa, Kei Nagashima
    • Journal Title

      Neuroscience Letters

      Volume: 665 Pages: 130-134

    • DOI

      10.1016/j.neulet.2017.11.053

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Systemic Estradiol Administration on Circadian Body Temperature and Activity Rhythms in Female Rats.2017

    • Author(s)
      Yuki Uchida, Shuri Marui, Ken Tokizawa, Kei Nagashima
    • Journal Title

      Anatomy & Physiology

      Volume: 7 Issue: 05 Pages: 1-6

    • DOI

      10.4172/2161-0940.1000280

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Systemic estradiol administration to ovariectomized rats facilitates thermoregulatory behavior in a cold environment2017

    • Author(s)
      Yuki Uchida, Kei Nagashima, Kazunari Yuri
    • Journal Title

      Brain Research

      Volume: 1670 Pages: 125-134

    • DOI

      10.1016/j.brainres.2017.06.009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of systemic estradiol administration on circadian body temperature and activity rhythms in female rats2017

    • Author(s)
      Yuki Uchida、Shuri Marui、Ken Tokizawa、Kei Nagashima
    • Organizer
      日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Modulation of circadian body temperature rhythm in fasted rodents2016

    • Author(s)
      Kei Nagashima
    • Organizer
      ICZ
    • Place of Presentation
      Okinawa, Japan
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 雌ラットにおけるエストラジオール欠乏が暗期暑熱時の耐熱能に及ぼす影響2016

    • Author(s)
      丸井朱里,永島計
    • Organizer
      日本生気象学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-04
    • Related Report
      2016 Research-status Report
  • [Presentation] メスマウスにおける体温調節とハドリングの関連性2016

    • Author(s)
      遠藤圭子,丸井朱里,加藤一聖,津谷彰,永島計
    • Organizer
      日本生気象学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-04
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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