The relationship between the capacity to oxidize fat and physical characteristics, lifestyle, and genes-cohort study-

• Project/Area Number: 16K13056
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Waseda University
• Principal Investigator: SAKAMOTO Shizuo 早稲田大学, スポーツ科学学術院, 教授 (00266032)
• Research Collaborator: HIGUCHI mitsuru ; MIDORIKAWA taishi ; KONISHI masayuki ; TANISAWA kumpei ; TABATA hiroki
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 脂質代謝能力 / 肥満 / 生活習慣病 / 身体特性 / 生活習慣 / 遺伝因子 / 最大脂質酸化量 / 最大酸素摂取量 / 内臓脂肪量 / アルコール摂取量 / インスリン抵抗性 / 遺伝子多型 / 遺伝的リスクスコア / 最大脂質酸化量時運動強度 / 一塩基多型(SNP) / 脂質代謝関連遺伝子 / 運動 / 食事

Outline of Final Research Achievements

The capacity to oxidize fat indicates the ability to using fat as an energy substrate and relates to obesity and life-related disease. However, there are few studies which investigate regulated factor of the capacity to oxidize fat. Therefore, we examined the relationship between the capacity to oxidize fat and physical characteristics, lifestyle, and genes in middle-aged Japanese people.
The capacity to oxidize fat was associated with sex, age, visceral fat mass, cardio-respiratory fitness, alcohol consumption, and exercise habits. As a result of genetic polymorphisms analysis, 33 single nucleotide polymorphisms, including arteriosclerotic related gene, were associated with the capacity to oxidize fat whereas insulin resistance related genes were not associated with the capacity to oxidize fat.
In the future, we will continue to conduct this cohort study to define the regulated factor of the capacity to oxidize fat.

Academic Significance and Societal Importance of the Research Achievements

これまでに報告されている、性別、心肺体力、身体組成に加えてアルコール摂取量や加齢も脂質代謝能力と関連する可能性が示唆された。脂質代謝能力はインスリン抵抗性と負の関連が報告されているが、インスリン抵抗性の関連遺伝子とは関連が認められなかった点より、脂質代謝能力の低下は関連遺伝子とは別の経路でインスリン抵抗性を引き起こしている可能性がある。
脂質代謝能力の低下は肥満や生活習慣病と関連する。脂質代謝能力を規定する要因が明確になれば、肥満や生活習慣病の予防・改善に有効な介入指標や評価指標となり得る。

Research Products

• [Journal Article] スポーツ心臓とは (2018)
  • Author(s): 坂本静男
  • Journal Title: 臨床スポーツ医学 Volume: 35(6) Pages: 540-545
• [Journal Article] Effects of different periods of rapid weight loss on dehydration and oxidative stress. (2018)
  • Author(s): Nishimaki M, Tabata H, Konishi M, Pettersson S, Sakamoto S.
  • Journal Title: Archives of Budo Volume: 14 Pages: 319-327
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lean soft tissue mass measured using dual-energy x-ray absorptiometry is an effective index for assessing change in leg skeletal muscle mass following exercise training. (2018)
  • Author(s): Midorikawa T, Ohta M, Torii S, Sakamoto S.
  • Journal Title: Journal of Clinical Densitometry Volume: ー Issue: 3 Pages: 394-398
  • DOI: 10.1016/j.jocd.2018.03.008
  • Peer Reviewed / Open Access
• [Journal Article] Mild Decrease in Skin Temperature Reduces the Heart Rate during Moderate Exercise (2017)
  • Author(s): Masayuki Konishi、Hiroki Tabata、Karina Ando、Hyeon-Ki Kim、Mio Nishimaki、Mi Xiang、Shizuo Sakamoto
  • Journal Title: Journal of Sports Science Volume: 5 Issue: 6 Pages: 305-312
  • DOI: 10.17265/2332-7839/2017.06.002
  • Peer Reviewed / Open Access
• [Journal Article] Influence of Watching Professional Baseball on Japanese Elders’ Affect and Subjective Happiness (2017)
  • Author(s): Kawakami Ryoko、Sawada Susumu S.、Ito Tomoko、Gando Yuko、Fukushi Tomohiro、Fujie Ryosuke、Oka Koichiro、Sakamoto Shizuo、Higuchi Mitsuru
  • Journal Title: Gerontology and Geriatric Medicine Volume: 3
  • DOI: 10.1177/2333721417721401
  • Peer Reviewed / Open Access
• [Journal Article] Visceral fat area is a strong predictor of leukocyte cell-derived chemotaxin 2, a potential biomarker of dyslipidemia (2017)
  • Author(s): Tanisawa K, Taniguchi H, Sun X, Ito T, Kawakami R, Sakamoto S, Higuchi M.
  • Journal Title: PLoS One Volume: 12(3) Issue: 3 Pages: e0173310-e0173310
  • DOI: 10.1371/journal.pone.0173310
  • Peer Reviewed / Open Access
• [Journal Article] Validity of segmental bioelectrical impedance analysis for estimating fat-free mass in children including overweight individuals (2017)
  • Author(s): Ohta M, Midorikawa T, Hikihara Y, Masuo Y, Sakamoto S, Torii S, Kawakami Y, Fukunaga T, Kanehisa H
  • Journal Title: Applied Physiology, Nutrition, and Metabolism Volume: 印刷中
  • Peer Reviewed
• [Journal Article] 中等度強度の持久性運動が唾液中の生化学成分および歯周病原細菌に与える影響 (2016)
  • Author(s): 清水寿男, 田端宏樹, 金 鉉基, 西牧未央, 安藤加里菜, 項 密, 小西真幸, 坂本静男
  • Journal Title: スポーツ歯学 Volume: 20 Pages: 1-6
  • NAID: 40020929978
  • Peer Reviewed
• [Journal Article] Reliability and validity of a Chinese-translated version of a pregnancy physical activity (2016)
  • Author(s): Xiang M, Konishi M, Hu HH, Takahashi M, Fan W, Nishimaki M, Ando K, Kim HK, Tabata H, Arao T, Sakamoto S
  • Journal Title: Maternal and Child Health Journal Volume: 20 Issue: 9 Pages: 1940-1947
  • DOI: 10.1007/s10995-016-2008-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of Different Intensities of Endurance Exercise in Morning and Evening on the Lipid Metabolism Response. (2016)
  • Author(s): Kim H-K, Ando K, Tabata H, Konishi M, Takahashi M, Nishimaki M, Xiang M, Sakamoto S
  • Journal Title: Journal of Sports Science and Medicine Volume: 15 Pages: 467-476
  • Peer Reviewed / Open Access
• [Journal Article] s There a Chronic Elevation in Organ-Tissue Sleeping Metabolic Rate in Very Fit Runners? (2016)
  • Author(s): Midorikawa T, Tanaka S, Ando T, Tanaka C, Konishi M, Ohta M, Torii S, Sakamoto S
  • Journal Title: Nutrients Volume: 8 Pages: 196-206
  • Peer Reviewed
• [Journal Article] Short-term high-fat diet alters postprandial glucose metabolism and circulating vascular cell adhesion molecule-1 in healthy males (2016)
  • Author(s): Numao S, Kawano H, Endo N, Yamada Y, Takahashi M, Konishi M, Sakamoto S
  • Journal Title: Applied Physiology, Nutrition, and Metabolism Volume: 41 Pages: 895-902
  • Peer Reviewed
• [Presentation] The relationship between organ-tissue of body composition and resting energy expenditure in prepubertal children. (2018)
  • Author(s): 1)Midorikawa T, Hikihara Y, Ohta M, Ando T, Torii S, Sakamoto S, Tanaka S.
  • Organizer: 11th International Symposium on IN VIVO BODY COMPOSITION STUDIES
  • Int'l Joint Research
• [Presentation] Effects of age on diving bradycardia and heart rate recovery in people older than 40 years. (2018)
  • Author(s): Konishi M, Tabata H, Higuchi M, Sakamoto S.
  • Organizer: 23rd Annual Congress of the European College of Sport Science
  • Int'l Joint Research
• [Presentation] 加齢は脂質代謝能力の性差に影響するか？-日本人中高年男女での検討 -WASEDA’s Health Study- (2018)
  • Author(s): 3)田端宏樹, 小西真幸, 川上諒子, 伊藤智子, 谷澤薫平, 鈴木克彦, 岡浩一朗, 樋口満, 坂本静男
  • Organizer: 第6回介護予防・健康づくり学会
• [Presentation] 一般中年男性における潜水徐脈反応と心肺体力の関連 (2018)
  • Author(s): 小西真幸, 田端宏樹, 樋口満, 坂本静男
  • Organizer: 第73回日本体力医学会
• [Presentation] Autonomic regulation in physically fit and recreationally active young and older men. (2017)
  • Author(s): Konishi, M., Kawano, H., Tabata, H., Kim, H.K., Xiang, M., Sakamoto, S.
  • Organizer: 22nd Annual Congress of the European College of Sport Science
• [Presentation] Is there a chronic elevation in organ-tissue sleeping metabolic rate in very fit runners ? (2017)
  • Author(s): Midorikawa, T., Tanaka, S., Ando, T., Tanaka, C., Konishi, M., Ohta, M., Torii, S., Sakamoto. S.
  • Organizer: 22nd Annual Congress of the European College of Sport Science
• [Presentation] The correlation between the ability to oxidize fat and net fat oxidation during prolonged exercise. (2017)
  • Author(s): H. Tabata, H-K. Kim, M. Konishi, S. Sakamoto.
  • Organizer: Exercise Metabolism
• [Presentation] 若年男性における安静時の脂質酸化量と最大脂質酸化量との関連 (2017)
  • Author(s): 田端宏樹, 金鉉基, 小西真幸, 坂本静男.
  • Organizer: 第72回日本体力医学会
• [Presentation] 肥満者の潜水徐脈反応は運動トレーニングにより変化するか？ (2017)
  • Author(s): 小西真幸, 金鉉基, 田端宏樹, 中村宣博, 坂本静男
  • Organizer: 第72回日本体力医学会
• [Presentation] 朝または夕方の12週間の運動が身体組成および代謝に及ぼす影響 (2017)
  • Author(s): 金鉉基, 小西真幸, 田端宏樹, 中村宣博, 髙橋将記, 柴田重信, 坂本静男
  • Organizer: 第72回日本体力医学会
• [Presentation] 肥満症に対する運動からのアプロ－チ―スポーツ医学の立場から― (2016)
  • Author(s): 坂本静男、金 鉉基、安藤加里菜、田端宏樹、小西真幸
  • Organizer: 日本肥満学会
  • Place of Presentation: 東京都江東区東京ファッションタウンビル
  • Year and Date: 2016-10-07
  • Invited
• [Presentation] Maximal fat oxidation and Fatmax are not associated with endurance performance in trained runners (2016)
  • Author(s): Hiroki Tabata, Hyeon-Ki Kim, Masayuki Konishi, Mio Nishimaki, Mi Xiang, Shizuo Sakamoto
  • Organizer: The 34th World Congress of Sports Medicine
  • Place of Presentation: Slovenia, Ljubljana
  • Year and Date: 2016-09-29
  • Int'l Joint Research
• [Presentation] Effects of increased daily physical activity on blood lipids and blood pressure in older adults (2016)
  • Author(s): Kim HK, Takahashi M, Konishi M, Tabata H, Nishimaki M, Xiang M, Sakamoto S
  • Organizer: The 34th World Congress of Sports Medicine
  • Place of Presentation: Slovenia, Ljubljana
  • Year and Date: 2016-09-29
  • Int'l Joint Research
• [Presentation] 皮膚温の2 ℃低下に着目した生理・生化学的な検討 －実験室および現地調査の報告－ (2016)
  • Author(s): 小西真幸, 坂本静男
  • Organizer: 第71回日本体力医学会
  • Place of Presentation: 岩手県盛岡市盛岡市民文化ホール
  • Year and Date: 2016-09-23
  • Invited
• [Presentation] Effect of aging on sex differences in fat oxidation (2016)
  • Author(s): abata, H., Kim, H-K., Konishi, M., Ando, K., Xiang, M., Suzuki, K., Higuchi, M., Sakamoto, S
  • Organizer: 21st Annual Congress of the European College of Sport Science
  • Place of Presentation: Austria, Vienna
  • Year and Date: 2016-07-06
  • Int'l Joint Research
• [Presentation] Mild decrease in skin temperature inhibits heart rate elevation during moderate exercise, but does not affect metabolism (2016)
  • Author(s): Konishi, M., Tabata, H., Ando, K., Kim, H.K., Nishimaki, M., Xiang, M., Sakamoto, S
  • Organizer: 21st Annual Congress of the European College of Sport Science
  • Place of Presentation: Austria, Vienna
  • Year and Date: 2016-07-06
  • Int'l Joint Research