Relationship between sarcopenic obesity and changes in adipokine secretion from adipose tissues with aging
| Project/Area Number |
16K13061
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脂肪細胞 / 筋芽細胞 / アディポカイン / マイオカイン / 脂肪組織 / C2C12 / 筋分化 / IGF-1 / 骨格筋 / サルコペニア |
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| Outline of Final Research Achievements |
In the super-aging society, the increase in the incidence of age-related diseases such as sarcopenic obesity becomes a problem. To elucidate the pathogenic mechanisms of sarcopenic obesity, the relationship of inhibition of myogenic differentiation with promotion of adipogenic differentiation by the interaction between adipocytes and myoblasts was examined in the study. The expression levels of adipokines in adipose tissues increased with aging and were influenced by immunocytes, not by adipocytes. Myogenic differentiation was controlled by insulin-like growth factor expression.
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Report
(3 results)
Research Products
(4 results)
