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Development of a Neuro-Rehabilitation System Based on Selfmonitoring of One's Motor Representation by Using a Small Humanoid Agent

Research Project

Project/Area Number 16K13063
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionNational Center for Geriatrics and Gerontology

Principal Investigator

NAKAI Toshiharu  国立研究開発法人国立長寿医療研究センター, 神経情報画像開発研究室, 室長 (30344170)

Co-Investigator(Kenkyū-buntansha) 田中 あゆ子  国立研究開発法人国立長寿医療研究センター, その他部局等, 研究員 (50463203)
加藤 昇平  名古屋工業大学, 工学(系)研究科(研究院), 教授 (70311032)
Research Collaborator BAGARINAO Epifanio  
YOSHIDA Akihiro  
UENO Mika  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords運動訓練システム / 運動表象符号化 / Neurofeedback / fMRI / 小型ヒューマノイド / 運動学習 / 身体座標系 / Brain Machine Interface / 運動訓練支援システム
Outline of Final Research Achievements

We developed a motor training method using a small humanoid manipulated by the brain activation pattern extracted by real-time fMRI monitoring of on-going task and employ its visual information as the neurofeedback information to the subject. By developing dual discriminant analysis updated according to the learning procedure, its potential capability as a brain machine interface using motor imagery training intuitively reflects the body coordinate was suggested. It has been turned out that global expansion of brain activation in older adults is not necessarily any disadvantage to the discriminant analysis and motor learning training using this method will be valid in older adults. A human robot interaction experiment showing the actual movement of small humanoid was performed. It was observed that the visual neurofeedback based self-representation of movement enhances positive motivation for physical exercises in older adults.

Academic Significance and Societal Importance of the Research Achievements

高齢者向けの運動訓練はフレイルや認知症予防への効果が期待されるが、今後は在宅で運動習慣を維持させる工夫が重要である。SHRを使った身体座標系を反映する自己動作の視覚的NFは、運動学習を行わせる神経リハビリの有力手段と成り得ると示唆された。学術的には、運動感覚統合を行うSalience NetworkがNF-fMRIによる運動学習の効率を反映する一方で、Default Mode Networkは一貫して加齢変化を反映する事が確認でき、安静時脳活動が有力な指標候補である事が明らかにされた意義が大きい。この知見は個人の特性や状況に合わせた運動処方の最適化に資すると考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (25 results)

All 2019 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (21 results) (of which Int'l Joint Research: 13 results)

  • [Journal Article] 安静時脳活動の解析手法概説2019

    • Author(s)
      中井敏晴
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 153-157

    • Related Report
      2018 Annual Research Report
  • [Journal Article] ディープラーニングによる脳機能画像分類の試み2019

    • Author(s)
      加藤昇平、中野智文、Epifanio Bagarinao、吉田旭宏、上野美果、中井敏晴
    • Journal Title

      BIO Clinica

      Volume: 34 Pages: 330-335

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Improved Volitional Recall of Motor-Imagery-Related Brain Activation Patterns Using Real-Time Functional MRI-based Neurofeedback.2018

    • Author(s)
      Bagarinao E, Yoshida A, Ueno M, Terabe K, Kato S, Isoda H, Nakai T
    • Journal Title

      Frontiers Hum Neuroscience 2018 #158

      Volume: 12 Pages: 1-13

    • DOI

      10.3389/fnhum.2018.00158

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Use of the sit-to-stand task to evaluate motorfunction of older adults using telemetry2016

    • Author(s)
      Kanai A, Kiyama S, Goto H, Tomita H, Tanaka A, Kunimi M, Okada T, Nakai T
    • Journal Title

      BMC Geriatrics16

      Volume: 121 Issue: 1 Pages: 1-10

    • DOI

      10.1186/s12877-016-0294-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Effectiveness of Multi-ROI 3D-CNNs in Discrimination of Motor Imagery from Functional Brain Image2019

    • Author(s)
      Nakano T, Kato S, Bagarinao E, Yoshida A, Ueno M, Nakai T
    • Organizer
      The 2019 IEEE 1st Global Conference on Life Sciences and Technologies (LifeTech 2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discrimination of Motor Imagery from Functional MR Image of Human Brain Using Multi-ROI 3D Convolutional Neural Networks2018

    • Author(s)
      Nakano T, Kato S, Bagarinao E, Yoshida A, Ueno M, Nakai T
    • Organizer
      2018 IEEE 7th Global Conference on Consumer Electronics (GCCE 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Real-time functional MRI-based neurofeedback improves volitional recall of brain activation patterns during motor imagery training2018

    • Author(s)
      Bagarinao E, Yoshida A, Ueno M, Terabe K, Kato S, Isoda H, Nakai T
    • Organizer
      BrainConnects 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] pplication of 3D convolutional neural networks for neuro-feedback training using real-time functional MRI2018

    • Author(s)
      Nakano T, Kato S, Bagarinao E, Yoshida A, Ueno M, Nakai T
    • Organizer
      BrainConnects 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Potentiality of 3D Convolutional Neural Networks to Discriminate Motor Imagery from a Functional Brain lmage of an Unknown Subject2018

    • Author(s)
      Nakano T, Kato S, Bagarinao E, Yoshida A, Ueno M, Nakai T
    • Organizer
      Third Annual Scientific Meeting of the Japanese Chapter of ISMRM
    • Related Report
      2018 Annual Research Report
  • [Presentation] fMRIを用いたリアルタイムニューロフィードバックシステムと3次元畳込みニューラルネットワークによる脳機能分類の提案2018

    • Author(s)
      中野 智文、加藤 昇平、バガリナオ エピファニオ、吉田旭宏、上野 美果、中井 敏晴
    • Organizer
      第32回人工知能学会全国大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Neurofeedback improves the classification of brain activation patterns during motor imagery task training: A real-time functional MRI study.2018

    • Author(s)
      Bagarinao E, Yoshida A, Ueno M, Kazunori Terabe K, Kato S, Isoda H, Nakai T
    • Organizer
      Second Annual Scientific Meeting of the Japanese Chapter of ISMRM
    • Related Report
      2017 Research-status Report
  • [Presentation] Sequential Activation in Sub-second Resolution during Semantic Memory Test: A Simultaneous EEG-fMRI Study2017

    • Author(s)
      Mizuno K, Bagarinao E, Maesawa S, Tohira S, Watanabe H, Nakai T, Isoda H
    • Organizer
      国際磁気共鳴医学会第一回学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2017-02-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Development of a Brain Machine Interface Using a Neurofeedback fMRI System - A Small Humanoid Represents Imagery Movements2017

    • Author(s)
      Yoshida A, Bagarinao E 3, Ueno M, Isoda H, Terabe K, Kato S, Nakai T
    • Organizer
      国際磁気共鳴医学会第一回学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2017-02-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Anterior Salience Network as a Potential Biomarker to Represent the Short-Term Effects of Verbal Training Exercise in Older Adults2017

    • Author(s)
      Nakai T, Ueno M, Tanaka A
    • Organizer
      国際磁気共鳴医学会第一回学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2017-02-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Community Based Physical Exercise Program Modulates the Brain Activities in Resting State Networks2017

    • Author(s)
      Ueno M, Tanaka A, Nakai T
    • Organizer
      国際磁気共鳴医学会第一回学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2017-02-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Neuroinformatics for Aging.2017

    • Author(s)
      Nakai T
    • Organizer
      BrainConnects 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Application of real Time Functional MRI for Motor Imagery Task.2017

    • Author(s)
      Bagarinao E
    • Organizer
      BrainConnects 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a Neurofeedback fMRI System Using Body Representation Visualized by a Small Humanoid.2017

    • Author(s)
      Yoshida A, Bagarinao E, Ueno M, Terabe K, Kato S, Isoda3 H, Nakai T
    • Organizer
      The 22nd Annual Meeting of Organization for Human Brain Mapping
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modulation of the Anterior Salience Network after 4 Weeks Verbal Training in Older Adults.2017

    • Author(s)
      Nakai T, Ueno M, Tanaka A
    • Organizer
      The 22nd Annual Meeting of Organization for Human Brain Mapping
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The INCF Neuroinformatics for Aging Special Interest Group Cooperation in neuroinformatics to accelerate validation of aging interventions.2017

    • Author(s)
      Nakai T, Ho ETW, Chen ASH, Yang GFP, Watanabe H, Tan MP
    • Organizer
      The 5th INCF Japan Node International Workshop -Advances in Neuroinformatics 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Use of a small humanoid robot as a neurofeedback system for motor imagery tasks.2017

    • Author(s)
      Bagarinao E, Yoshida A, Ueno M, Terabe K, Kato S, Isoda H, Nakai T
    • Organizer
      real-time functional imaging and neurofeedback conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Real-time fMRI を使用した小型ヒューマノイド Neurofeedback システムの構築2016

    • Author(s)
      吉田旭宏、エピファニオ バガリナオ、上野美果、寺部和紀、加藤昇平、礒田治夫、中 井敏晴
    • Organizer
      平成28年度日本生体医工学会東海支部大会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-10-22
    • Related Report
      2016 Research-status Report
  • [Presentation] The Effects of Physical Exercises on Aging Brain - Morphological and Functional Analysis2016

    • Author(s)
      Nakai T
    • Organizer
      BrainConnects 2016
    • Place of Presentation
      Taichung, Taiwan
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dpendency of the Activations Detected in Resting State Networks on the History of Physical Exercise in Older Adults2016

    • Author(s)
      Ueno M, Kiyama S, Suzuki A, Nakai T
    • Organizer
      BrainConnects 2016
    • Place of Presentation
      Taichung, Taiwan
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Building an Activation Map Driven Operation System for a Small Humanoid Using Real-time fMRI- An Initial Report2016

    • Author(s)
      Yoshida A, Bagarinao E, Kato S, Ueno M, Isoda H, Nakai T
    • Organizer
      BrainConnects 2016
    • Place of Presentation
      Taichung, Taiwan
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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