Chemical biology of multifunctional transporter GTR1
Project/Area Number |
16K13083
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Biomolecular chemistry
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Research Institution | Tohoku University |
Principal Investigator |
Ueda Minoru 東北大学, 理学研究科, 教授 (60265931)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 植物ホルモン輸送体 / GTR1 / NPR family / 輸送体 / Arabidopsis thaliana / ジャスモン酸イソロイシン / ジベレリン / グルコシノレート / 植物二次代謝産物 |
Outline of Final Research Achievements |
Spatiotemporal distributions of plant hormones are regulated strictly through corresponding transporter proteins. GTR1 was found first found as a transporter of a jasmonoyl isoleucine (JA-Ile) and belongs to a NPF family to which 53 member proteins belong. Surprisingly, further studies strongly suggested that GTR1 is a unique `multi-functional` transporter which can transport three different kinds of plant metabolites, JA-Ile, gibberelin, and glucosinolate, across the membrane with structure recognition. We also found that the homo-dimerization of GTR1 is responsible for glucosinolate transport and heterodimerization with other NPF family protein is responsible for the transport of JA-Ile and GA. This is the first example of dimerization-mediated switching of substrate for transporter.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] GTR1 is a jasmonic acid and jasmonoyl-l-isoleucine transporter in Arabidopsis thaliana.2017
Author(s)
Ishimaru, Y., Oikawa, T., Suzuki, T., Takeishi, S., Matsuura, H., Takahashi, K., Hamamoto, S., Uozumi, N., Shimizu, T., Seo, M., Ohta, H., and Ueda, M.
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 81
Issue: 2
Pages: 249-255
DOI
Related Report
Peer Reviewed