Reprogramming of the polyketide synthase/peptide synthetase from Streptomyces
| Project/Area Number |
16K13084
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomolecular chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Abe Ikuro 東京大学, 大学院薬学系研究科(薬学部), 教授 (40305496)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 合成生物学 / 生合成 / 天然物化学 / 酵素工学 / 構造生物学 / アンチマイシン |
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| Outline of Final Research Achievements |
Reprogramming of the NRPS/PKS assembly line is an attractive method for the creation of novel bioactive molecules. In this study, we successfully accomplished three manipulations: i) ring contraction, ii) ring expansion, and iii) alkyl chain diversification, to generate a set of unnatural novel derivatives in practical yields. This study presented a useful strategy for engineering NRPS-PKS module enzymes.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides2017
Author(s)
Zhang, L., Hashimoto, T., Qin, B., Hashimoto, J., Kozone, I., Kawahara, T., Okada, M., Awakawa, T., Ito, T., Asakawa, Y., Ueki, M., Takahashi, S., Osada, H., Wakimoto, T., Ikeda, H., Shin-ya, K., Abe, I.
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Journal Title
Angew. Chem. Int. Ed.
Volume: 56
Issue: 7
Pages: 1740-1745
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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