| Project/Area Number |
16K13086
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 海洋天然物 / 生体膜 / 膜脂質 / 酵母変異株 / 組織的解析 / 再構築 |
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| Outline of Final Research Achievements |
Identification of the primary target of bioactive compounds is highly important, for understanding life at a molecular level and drug development. Many strategies for revealing protein targets of small molecules has been developed, while it is not easy to clarify how membrane-targeting molecules recognize membrane lipids. This is because a huge number of molecular species exist in the cell membrane, making specific environments that is favored/disfavored by small molecules. In this study, we tested drug sensitivity of fission yeast lipid mutants, analyzed lipids in these mutant cells, and examined how lipids are recognized by small molecules using artificial membranes and natural or synthetic lipid derivatives.
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