• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation of abnormalities of brain semantic network in schizophrenia

Research Project

Project/Area Number 16K13106
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Research InstitutionKyoto University

Principal Investigator

Takahashi Hidehiko  京都大学, 医学研究科, 准教授 (60415429)

Co-Investigator(Kenkyū-buntansha) 西本 伸志  国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳情報通信融合研究室, 主任研究員 (00713455)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords統合失調症 / fMRI / 神経科学 / 認知神経科学 / fMRI
Outline of Final Research Achievements

The whole brain activity during movie watching was continuously recorded from schizophrenia patients and healthy controls by 3T fMRI. A coefficient matrix (word vector in the brain) was obtained from time series of nouns included in the movie and brain activity data. The matrix illustrates the relationship between regional brain activity and combination of nouns. For this brain word vector, network analysis using graph theory was applied. Compared with healthy subjects, a categorical structure was disorganized in the brain semantic network, and the relationship between the superordinate concept and the subordinate concept was also unnatural in schizophrenia.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results)

  • [Int'l Joint Research] Univeristy College London(英国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Decoding naturalistic experiences from human brain activity via distributed representations of words.2018

    • Author(s)
      Nishida S, Nishimoto S
    • Journal Title

      NeuroImage

      Volume: - Pages: 232-242

    • DOI

      10.1016/j.neuroimage.2017.08.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 統合失調症の思考障害と脳内意味表象異常2018

    • Author(s)
      松本 有紀子, 高橋 英彦
    • Journal Title

      Medical Science Digest

      Volume: 44 Pages: 70-72

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Additive Effect of Cigarette Smoking on Gray Matter Abnormalities in Schizophrenia2017

    • Author(s)
      Yokoyama Naoto、Sasaki Hitoshi、Mori Yasuo、Ono Miki、Tsurumi Kousuke、Kawada Ryosaku、Matsumoto Yukiko、Yoshihara Yujiro、Sugihara Genichi、Miyata Jun、Murai Toshiya、Takahashi Hidehiko
    • Journal Title

      Schizophr Bull.

      Volume: 1 Pages: 1-10

    • DOI

      10.1093/schbul/sbx092

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural basis of altered earlier attention and higher order biological motion processing in schizophrenia.2017

    • Author(s)
      Matsumoto Y, Takahashi H, Miyata J, Sugihara G, Murai T, Takahashi H.
    • Journal Title

      Social Neuroscience

      Volume: Aug 25 Issue: 5 Pages: 1-8

    • DOI

      10.1080/17470919.2017.1366363

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 意味認知と脳内情報表現2017

    • Author(s)
      西田知史, 西本伸志
    • Journal Title

      人工知能

      Volume: 32 Pages: 857-862

    • NAID

      130007917371

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Lateralization of intrinsic frontoparietal network connectivity and symptoms in schizophrenia.2017

    • Author(s)
      on S, Miyata J, Mori Y, Isobe M, Urayama SI, Aso T, Fukuyama H, Murai T, Takahashi H.
    • Journal Title

      Psychiatry Res.

      Volume: 260 Pages: 23-28

    • DOI

      10.1016/j.pscychresns.2016.12.007

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ambiguity aversion in schizophrenia: An fMRI study of decision-making under risk and ambiguity.2016

    • Author(s)
      Fujino J, Hirose K, Tei S, Kawada R, Tsurumi K, Matsukawa N, Miyata J,Sugihara G, Yoshihara Y, Ideno T, Aso T, Takemura K, Fukuyama H, Murai T,Takahashi H.
    • Journal Title

      Schizophrenia Research

      Volume: 178(1-3) Issue: 1-3 Pages: 94-101

    • DOI

      10.1016/j.schres.2016.09.006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Distinct Patterns of Cerebral Cortical Thinning in Schizophrenia: A Neuroimaging Data-Driven Approach.2016

    • Author(s)
      Sugihara G, Oishi N, Son S, Kubota M, Takahashi H, Murai T.
    • Journal Title

      Schizophr Bull.

      Volume: - Pages: 900-906

    • DOI

      10.1093/schbul/sbw176

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Abnormal semantic representation in the brains of schizophrenia patients2017

    • Author(s)
      Yukiko Matsumoto, Shuraku Son, Akio Murakami, Satoshi Nishida, Shinji Nishimoto, Hidehiko Takahashi
    • Organizer
      第19回日本ヒト脳機能マッピング学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高次視覚野応答のエンコーディングによる統合失調症の脳内意味表象異常の評価2017

    • Author(s)
      松本有紀子、孫樹洛、村上晶郎、西田知史、西本伸志、高橋英彦
    • Organizer
      第1回ヒト脳イメージング研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 統合失調症における脳内意味表象異常の可視化と定量2017

    • Author(s)
      松本有紀子
    • Organizer
      次世代脳 4領域合同若手シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 人工知能と統合失調症研究の接点2017

    • Author(s)
      高橋英彦
    • Organizer
      山陰精神神経学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Altered decision-making as endophenotypes to bridge the gap between phenomenology and neurobiology.2017

    • Author(s)
      Hidehiko Takahashi
    • Organizer
      44th Naito Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Interface between AI and psychiatric research2017

    • Author(s)
      Hidehiko Takahashi
    • Organizer
      Gatsby-Kaken Joint Workshop on AI and Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Linking neuroscience and machine learning via latent features of natural stimuli2017

    • Author(s)
      Shinji Nishimoto
    • Organizer
      Gatsby-Kakenhi Joint Workshop on AI and Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Connecting natural experiences and the brain2017

    • Author(s)
      Shinji Nishimoto
    • Organizer
      RIKEN BSI Summer Program
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi