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Effect of early life stress on impulsive aggression and neural circuit in the prefrintal cortex

Research Project

Project/Area Number 16K13111
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Research InstitutionTottori University

Principal Investigator

Hata Yoshio  鳥取大学, 医学(系)研究科(研究院), 教授 (40212146)

Co-Investigator(Kenkyū-buntansha) 一坂 吏志  鳥取大学, 医学部, 助教 (50359874)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords前頭前野 / 扁桃体 / 神経回路 / ストレス
Outline of Final Research Achievements

The present study explores the postnatal development of neural mechanism of impulsive aggression in rats. I examined behavioral effects of pharmacological inhibition of neural activity in the orbitofrontal cortex. The inhibition of orbitofrontal cortex increased impulsive aggression, showing that the orbitofrontal cortex suppresses impulsive aggression as reported in human. Also, I developed a novel animal model to study the effect of early life stress which combines physical stress by electric shock with social isolation. In addition, I found a novel anxiety-like behavior in the open field test, which is the leaning behavior against the wall at high position.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Early deprivation increases high-leaning behavior, a novel anxiety-like behavior, in the open field test in rats2017

    • Author(s)
      Kuniishi Hiroshi、Ichisaka Satoshi、Yamamoto Miki、Ikubo Natsuko、Matsuda Sae、Futora Eri、Harada Riho、Ishihara Kohei、Hata Yoshio
    • Journal Title

      Neuroscience Research

      Volume: 123 Pages: 27-35

    • DOI

      10.1016/j.neures.2017.04.012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic inactivation of the orbitofrontal cortex increases anxiety- like behavior and impulsive aggression, but decreases depression-like behavior in rats.2017

    • Author(s)
      Kuniishi H., Ichisaka S., Matsuda S., Futora E., Harada R. and Hata Y.
    • Journal Title

      Front. Behav. Neurosci.

      Volume: 10 Pages: 250-250

    • DOI

      10.3389/fnbeh.2016.00250

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ラットにおける新規幼少期ストレス負荷による行動、コルチコステロン、脳構造への影響と治療法の検討2017

    • Author(s)
      窪堀 希、一坂吏志、國石 洋、松田紗衣、太等恵里、原田里穂、石原康平、畠 義郎
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 不安・うつ様行動、衝動的攻撃性へのラット眼窩前頭皮質の関与2016

    • Author(s)
      國石 洋、一坂吏志、松田紗衣、太等恵里、原田里穂、石原康平、窪堀 希、福田世実、畠 義郎
    • Organizer
      第59回日本神経化学会大会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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