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Challenge to a novel measurement method of brain functions by detecting neural magnetic fields with ultra-high-sensitivity optical magnetic sensors

Research Project

Project/Area Number 16K13114
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Brain biometrics
Research InstitutionKyoto University

Principal Investigator

Kobayashi Tetsuo  京都大学, 工学研究科, 教授 (40175336)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脳機能 / 原子磁気センサ / MEG / fMRI / MRI / 神経磁場
Outline of Final Research Achievements

Towards novel measurement methods of neural activities based on tiny magnetic fields generated from them, we fabricated a high-sensitivity multi-channel optically pumped atomic magnetometer with a K-Rb hybrid cell. We demonstrate that high-density measurements of the magnetic field distributions with the interval of 4 mm could be achieved. Meanwhile, we developed a spin-lock MR sequence and were able to detect oscillatory magnetic fields directly with is as the change in MR signals. In addition, we showed the possibility of the direct measurement of functional connectivity based on MR signal contrasts depending on initial phases.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (35 results)

All 2018 2017 2016 Other

All Journal Article (13 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 5 results) Presentation (21 results) (of which Int'l Joint Research: 14 results,  Invited: 10 results) Remarks (1 results)

  • [Journal Article] High-sensitivity multi-channel probe beam detector towards MEG measurements of small animals with an optically pumped K-Rb hybrid magnetometer2018

    • Author(s)
      Nishi Kazumasa、Ito Yosuke、Kobayashi Tetsuo
    • Journal Title

      Optics Express

      Volume: 26 Issue: 2 Pages: 1988-1988

    • DOI

      10.1364/oe.26.001988

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 光ポンピング原子磁気センサと超低磁場MRI2018

    • Author(s)
      小林哲生
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 74 Pages: 179-182

    • Related Report
      2017 Annual Research Report
  • [Journal Article] SQUID & 光ポンピング原子磁気センサ2018

    • Author(s)
      小林哲生
    • Journal Title

      日本磁気学会誌

      Volume: 13

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 光ポンピング原子磁気センサによる小動物の脳磁図計測に向けたの高感度マルチチャネルプローブ光検出器2017

    • Author(s)
      西 和将,伊藤陽介,小林哲生
    • Journal Title

      電気学会マグネティックス研究会資料

      Volume: MAG-17-211 Pages: 1-6

    • Related Report
      2017 Annual Research Report
  • [Journal Article] ラプラス変換を用いた光ポンピング原子磁気センサの過渡応答に関する検討2017

    • Author(s)
      伊藤陽介,小林哲生
    • Journal Title

      電気学会マグネティックス研究会資料

      Volume: MAG-17-224 Pages: 57-62

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 自動クラスタリングした白質神経線維束に基づくNODDIプロファイル解析法の提案2017

    • Author(s)
      井田和希、奥畑志帆、中井隆介、小林哲生
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 117(360) Pages: 29-34

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 0.3T 低磁場MRIを用いた機能的結合の直接計測に向けたスピンロック撮像法:信号源における振動磁場の位相差が及ぼす影響の検討2017

    • Author(s)
      關祐亮、上田博之、伊藤陽介、笈田武範、谷口 陽,小林哲生
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 117(360) Pages: 29-34

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 小型磁気センサモジュールを用いた遠隔磁気粒子イメージング:励磁磁場強度最適化の検討2017

    • Author(s)
      加藤健太郎、笈田武範、伊藤陽介、小林哲生
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 117(360) Pages: 55-60

    • Related Report
      2017 Annual Research Report
  • [Journal Article] A novel method to accomplish simultaneous multilocation magnetic field measurements based on pump beam modulation of an atomic magnetometer2017

    • Author(s)
      Yuki Mamishin, Yosuke Ito and Tetsuo Kobayashi
    • Journal Title

      IEEE Trans. on Magnetics

      Volume: 53(5) Issue: 5 Pages: 1-6

    • DOI

      10.1109/tmag.2017.2659649

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Optimal densities of alkali metal atoms in an optically pumped K-Rb hybrid atomic magnetometer considering spatial distribution of spin polazization2016

    • Author(s)
      Yosuke Ito, Daichi Sato, Keigo Kamada and Tetsuo Kobayashi
    • Journal Title

      Optics Express

      Volume: 24(14) Issue: 14 Pages: 15391-15402

    • DOI

      10.1364/oe.24.015391

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 低磁場MRIによる脳神経磁場計測実現に向けた基礎的検討2016

    • Author(s)
      關 祐亮、伊藤陽介、小林哲生
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 116(58) Pages: 13-18

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] 脳磁図計測に向けた原子磁気センサにおけるグラジオメータ構成法に応じたノイズ低減効果の検討2016

    • Author(s)
      小島史嵩, 伊藤 陽介, 小林哲生
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 116(342) Pages: 47-52

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] ポンプ光変調による原子磁気センサを用いた複数点同時計測法:電気光学変調方式による2点同時計測に関する研究2016

    • Author(s)
      馬見新友輝、伊藤陽介、小林哲生
    • Journal Title

      電気学会マグネティックス研究会資料

      Volume: MAG-16-236 Pages: 81-86

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] 0.3T低磁場MRIにおけるスピンロック撮像法を用いた脳機能イメージング:振動磁場の位相情報がもたらす影響の検討2017

    • Author(s)
      關祐亮、上田博之、伊藤陽介、小林哲生
    • Organizer
      第19回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 0.3T低磁場MRIにおけるスピンロック撮像法を用いた脳機能イメージング:脳神経磁場の検出限界に関する検討2017

    • Author(s)
      上田博之、關祐亮、伊藤陽介、小林哲生
    • Organizer
      第19回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Optically pumped atomic magnetometer2017

    • Author(s)
      Tetsuo Kobayashi
    • Organizer
      Satellite Symposium in Biomagnetic Sendai 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Compact atomic magnetometer modules and their biomagnetic applications2017

    • Author(s)
      Tetsuo Kobayashi
    • Organizer
      Biomagnetic Sendai 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Developments and perspectives of innovative neuroimaging technologies with optically pumped atomic magnetometers2017

    • Author(s)
      Tetsuo Kobayashi
    • Organizer
      Basic and Clinical Multimodal Imaging: BaCI2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Quantitative evaluation methods of MR-diffusion information along white mater nerve bundles towards identification of neural circuits associated with neuropsychiatric disorders2017

    • Author(s)
      Tetsuo Kobayashi, Shiho Okuhata, Hodaka Miki, Satoki Yoda, Ryusuke Nakai, Takenori Oida and Kazuki Ida
    • Organizer
      The 11th International Conference on Complex Medical Engineering CME2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rapid scan using compressed sensing in ultra-low field MRI with optically pumped atomic magnetometer2017

    • Author(s)
      Tekenori Oida, Kazuhiro Tamiwa, Hiroyuki Ueda and Tetsuo Kobayashi
    • Organizer
      The 11th International Conference on Complex Medical Engineering CME2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 光ポンピング原子磁気センサと超低磁場MRI2017

    • Author(s)
      小林哲生
    • Organizer
      日本放射線技術学会第73回総合学術大会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] SWIFT imaging for hyperpolarized xenon in ultra-low field MRI2017

    • Author(s)
      Takenori Oida, Yuki Kaga, Tetsuya Yamamoto and Tetsuo Kobayashi
    • Organizer
      ISMRM 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurements of magnetic action fields of the median nerve with a multi-channel atomic magnetometer module2017

    • Author(s)
      Tsukasa Moriguchi, Yosuke Ito and Tetsuo Kobayashi
    • Organizer
      Biomagnetic Sendai 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A probe beam detection method towards multi-channel MEG measurements for small animals with optically pumped atomic magnetometers2017

    • Author(s)
      Nishi Kazumasa, Yosuke Ito and Tetsuo Kobayashi
    • Organizer
      Biomagnetic Sendai 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control on bandwidth of an optically pumped atomic magnetometer by negative feedback2017

    • Author(s)
      Sho Ito, Yosuke Ito and Tetsuo Kobayashi
    • Organizer
      Biomagnetic Sendai 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A simultaneous multi-location measurement method based on pump-beam modulation of atomic magnetometers by electro-optic modulation2017

    • Author(s)
      Yosuke Ito, Yuki Mamishin and Tetsuo Kobayashi
    • Organizer
      5th Workshop on Optically Pumped Magnetometer 2017 (WOPM-2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 機能的spin-lock撮像法における磁化ダイナミクスの解析的な検討2017

    • Author(s)
      上田博之、關祐亮、伊藤陽介、笈田武範、谷口 陽,小林哲生
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 0.3T 低磁場MRIを用いた機能的結合の直接計測に向けたスピンロック撮像法の検討2017

    • Author(s)
      關祐亮、上田博之、伊藤陽介、笈田武範、谷口 陽,小林哲生
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Optically pumped atomic magnetometer and its application to neuroimaging2016

    • Author(s)
      Tetsuo Kobayashi
    • Organizer
      International Symposium on Applied Brain Science
    • Place of Presentation
      Beijing, China
    • Year and Date
      2016-12-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Atomic magnetometer: Advancements and Perspectives for Optical Biomagnetic Imaging Systems2016

    • Author(s)
      Tetsuo Kobayashi
    • Organizer
      International Workshop on Magnetic Bio-Sensing
    • Place of Presentation
      Fukuoka
    • Year and Date
      2016-10-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 光ポンピング原子磁気センサを用いた生体磁気計測に向けたのプローブ光検出方法の検討2016

    • Author(s)
      西 和将,小島史嵩,馬見新友輝,伊藤陽介,小林哲生
    • Organizer
      第31回日本生体磁気学会大会
    • Place of Presentation
      金沢
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 光ポンピング磁気センサ似よる生体磁気計測を目指した3次元磁場分布計測2016

    • Author(s)
      伊藤陽介、馬見新友輝、小島史嵩、小林哲生
    • Organizer
      第31回日本生体磁気学会大会
    • Place of Presentation
      金沢
    • Year and Date
      2016-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Advancements of Atomic Magnetometers and Optical Biomagnetic Imaging Systems2016

    • Author(s)
      Tetsuo Kobayashi
    • Organizer
      Workshop on ultra-low-filed MRI
    • Place of Presentation
      Deajeon, Korea
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of compact OPMs towards innovative biomagnetic imaging systems2016

    • Author(s)
      Tetsuo Kobayashi
    • Organizer
      Biomag2016 Satellite Meeting on Optically-Pumped Magnetometers for Biomedical Applications
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 京都大学大学院工学研究科電気工学専攻生体機能工学分野

    • URL

      http://bfe.kuee.kyoto-u.ac.jp/publications.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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