Ecohealth approach to public health intervention on Schistosoma mekongi

• Project/Area Number: 16K13126
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Area studies
• Research Institution: Nagasaki University
• Principal Investigator: MOJI Kazuhiko 長崎大学, 熱帯医学・グローバルヘルス研究科, 教授 (80166321)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: エコヘルス・アプローチ / 患者登録システム / 環境改善 / リスク暴露削減

Outline of Final Research Achievements

Schistosoma mekongi is an infectious disease caused by flukes and endemic in the Mekong river basin on the Lao-Cambodian border. As its transmission cycle is entangled with local ecosystem and the behavior of local human population, mass drug administration (MDA) has limited impact on control and prevention. Based on the method of area studies, ecohealth approach should be developed for effective intervention. With this goal in mind, this study investigated the prevalence in an endemic area to identify the problem in past control procedure. Stool examination found the relatively high prevalence in spite of the treatment recently given. Questionnaire survey found that most people are ignorant of cause and prevention of the disease. We also found the MDAs were implemented without individual registration so that we cannot track the outcome of past treatment. It is necessary to set up long-term surveillance system for control program to be more effective.

Research Products

• [Int'l Joint Research] 公衆衛生研究所(ラオス)
• [Int'l Joint Research] マヒドン大学(タイ)
• [Journal Article] The role of domestic dogs in the transmission of zoonotic helminthes in a rural area of Mekong river basin. (2017)
  • Author(s): Otake Sato M, Sato M, Yoonuan T, Pongvongsa T, Sanguankiat S, Kounnavong S, Maipanich W, Chigusa Y , Moji K, Waikagul J.
  • Journal Title: Acta Parasitol Volume: 62(2) Issue: 2 Pages: 393-400
  • DOI: 10.1515/ap-2017-0047
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Density dependence in a seasonal time series of the bamboo mosquito, Tripteroides bambusa (Diptera: Culicidae) (2017)
  • Author(s): Tomonori Hoshi, Nozomi Imanishi, Kazuhiko Moji and Luis Fernando Chaves
  • Journal Title: The Canadian Entomologist Volume: 149 Issue: 3 Pages: 1-7
  • DOI: 10.4039/tce.2016.64
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Application of environmental DNA analysis for the detection of Opisthorchis viverrini DNA in water samples. 2017 May;:. doi: 10.1016/j.actatropica.2017.01.008. Epub Jan 17. PMID: 28108370 (2017)
  • Author(s): Hashizume H, Sato M, Sato MO, Ikeda S, Yoonuan T, Sanguankiat S, Pongvongsa T, Moji K, Minamoto T.
  • Journal Title: Acta Trop. Volume: 169 Pages: 1-7
  • DOI: 10.1016/j.actatropica.2017.01.008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] メコン川下流水田域における生業、土地利用、 生態系サービス (2017)
  • Author(s): 神松幸弘・富田晋介・丸山敦・船津耕平・門司和彦
  • Journal Title: 環太平洋文明研究 Volume: 1 Pages: 69-92
  • Peer Reviewed
• [Journal Article] Household clustering of asymptomatic malaria infections in Xepon district, Savannakhet province, Lao PDR (2016)
  • Author(s): Tiengkham Pongvongsa, Daisuke Nonaka, Moritoshi Iwagami, Masami Nakatsu, Panom Phongmany, Futoshi Nishimoto, Jun Kobayashi, Bouasy Hongvanthon, Paul T. Brey, Kazuhiko Moji, Toshihiro Mita and Shigeyuki Kano
  • Journal Title: Malaria Journal Volume: 15 Issue: 1 Pages: 508-508
  • DOI: 10.1186/s12936-016-1552-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Morbidity assessment of Opisthorchis viverrini infection in rural Laos: I. Parasitological, clinical, ultrasonographical and biochemical findings (2016)
  • Author(s): Hermann Feldmeier, Miklos Hazay, Megumi Sato, Pongvongsa Tiengkham, Futoshi Nishimoto, Hongwei Jiang, Vatsana Sopraseuth, and Kazuhiko Moji
  • Journal Title: Tropical Medicine and Health Volume: 44(12) Issue: 1 Pages: 69-78
  • DOI: 10.1186/s41182-016-0012-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Asymptomatic malaria, growth status, and anaemia among children in Lao People's Democratic Republic: a cross-sectional study (2016)
  • Author(s): Takeshi Akiyama, Tiengkham Pongvongsa, Souraxay Phrommala, Tomoyo Taniguchi, Yuba Inamine, Rie Takeuchi, Tadashi Watanabe, Futoshi Nishimoto, Kazuhiko Moji, Shigeyuki Kano, Hisami Watanabe, and Jun Kobayashi
  • Journal Title: Malaria Journal Volume: 15 Issue: 1 Pages: 499-499
  • DOI: 10.1186/s12936-016-1548-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] First Record of Paramphistomes Fischoederius cobboldi and Paramphistomum epiclitum Detected in Bovine Rumen from a Local Market of Savannakhet Province, Lao PDR (2016)
  • Author(s): Surapol Sanguankiat, Marcello Otake Sato, Megumi Sato, Wanna Maipanich, Tippayarat Yoonuan, Tiengkham Pongvongsa, Boungnong Boupha, Yuichi Chigusa, Kazuhiko Moji, and Jitra Waikagul
  • Journal Title: The Korean Journal of Parasitology Volume: 54 Issue: 4 Pages: 543-547
  • DOI: 10.3347/kjp.2016.54.4.543
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Application of enviromental DNA analysis for the detection of Opisthorchis viverrini DNA in water samples (2017)
  • Author(s): Kazuhiko Moji, Toshifumi Minamoto, Hiroki Hashizume, Megumi Sato, Marcello Otake Sato, Sumire Ikeda, Tippayarat Yoonuan, Surapol Sanguankiat, and Tiengkham Pongvongsa
  • Organizer: NTDASIA2017
  • Place of Presentation: Khon Kaen University, Khon Kaen, Thailand
  • Year and Date: 2017-03-08
  • Int'l Joint Research
• [Presentation] Difference of Risk Factors of Schistosomiasis, Opisthorchiasis and Hookworm Infection among Adults and Children in Southern Lao PDR (2017)
  • Author(s): Takuya Shizume, Somphou Sayasone, Souraxay Phrommala, Sengchan Kounnavong, Syda Sayyavong, Shigeyuki Kano, Moritoshi Iwagami, Eisaku Kimura , Hisakazu Hiraoka , Tomonori Hoshi , Kazuhiko Moji
  • Organizer: Lao PDR 11th National Health Research Forum
  • Int'l Joint Research