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A novel behavioral task for investigating a mixture of model-free and model-based reinforcement learning in rodents

Research Project

Project/Area Number 16K13505
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Experimental psychology
Research InstitutionNagoya University

Principal Investigator

Mizoguchi Hiroyuki  名古屋大学, 環境医学研究所, 講師 (70402568)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsモデルフリー・モデルベース / 意思決定 / 行動選択
Outline of Final Research Achievements

Decision-making and reinforcement learning arise from the involvement of two distinct processes that control choice, known as model-based and model-free strategies. Model-based choices are prospective, whereas model-free choices are retrospective. In general, normal performance depends on the flexible integration of model-based and model-free control. In this research, we employed a two-step sequential visual discrimination learning of complex stimuli in touch-screen task to establish a novel behavioral system for investigating a mixture of model-free and model-based reinforcement learning in rodent. Rats chose option on the reward amount- and provability-dependent manner. However, we failed to find best fitting behavioral modeling and parameters. We need to continue our experiments in future studies.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (10 results) (of which Invited: 1 results)

  • [Journal Article] Disrupted axon-glia interactions at the paranode in myelinated nerves cause axonal degeneration and neuronal cell death in the aged Caspr mutant mouse shambling.2016

    • Author(s)
      Takagishi Y, Katanosaka K, Mizoguchi H, Murata Y.
    • Journal Title

      Neurobiology of Aging

      Volume: 43 Pages: 34-46

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] タッチスクリーン式弁別課題を用いた認知機能解析システムの確立2018

    • Author(s)
      Md.Ali Bin Saifullah, 山中宏二,溝口博之
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 依存性薬物がもたらす認知・意思決定異常2017

    • Author(s)
      溝口博之,山田清文
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 島皮質GABA神経の機能操作は意思決定に影響する2017

    • Author(s)
      溝口博之,犬束 歩,片平健太郎,山田清文
    • Organizer
      次世代を担う創薬・医療管理シンポジウム 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] タッチスクリーン式弁別課題を用いた認知機能解析システムの確立2017

    • Author(s)
      Md.Ali-Bin-Saifullah,溝口博之
    • Organizer
      次世代を担う創薬・医療管理シンポジウム 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] リスク下の意思決定における島皮質GABA神経の役割2017

    • Author(s)
      溝口博之,犬束 歩,片平健太郎,山田清文
    • Organizer
      平成29年度アルコール・薬物依存関連学会合同学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Nicotinic acetylcholine receptor as a target of harm reduction and treatment in addiction.2016

    • Author(s)
      Mizoguchi H, Yamada K.
    • Organizer
      第51回日本アルコール・アディクション医学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 意思決定障害と創薬標的としてのニコチン受容体2016

    • Author(s)
      溝口博之、山田清文
    • Organizer
      第18回応用薬理シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2016-08-05
    • Related Report
      2016 Research-status Report
  • [Presentation] 島皮質GABA神経は薬物依存ラットの意思決定に関与する2016

    • Author(s)
      溝口博之、山田清文
    • Organizer
      第39回日本神経科学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 薬物依存症における意思決定異常2016

    • Author(s)
      溝口博之、山田清文
    • Organizer
      第46日本神経精神薬理学会年会
    • Place of Presentation
      ソウル
    • Year and Date
      2016-07-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 薬物依存における意思決定と島皮質機能障害2016

    • Author(s)
      溝口博之
    • Organizer
      第34回日本生理心理学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-05-14
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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