Applications of nanofiber needles to Raman-based optical analysis in single cells
| Project/Area Number |
16K13646
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Nanobioscience
|
|---|
| Research Institution | Osaka City University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
湯川 博 名古屋大学, 未来社会創造機構, 特任准教授 (30634646)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | ナノ光ファイバ / 一細胞解析 / 再生医療 / 細胞 / ナノ光デバイス / 生体計測 / ラマン散乱 / ナノバイオ / マイクロ・ナノデバイス / 細胞・組織 |
|---|
| Outline of Final Research Achievements |
Real-time single cell analysis is an important technological milestone that may enable diagnosing cancer or senescence of single stem cells in regenerative medicine. The project is aimed to develop such a single cell analysis in a remote-sensing style for cells in living organisms by using optical nanofibers. We fabricated needle-shape nanofibers by a newly developed hydrogen-oxygen micro torch to form arbitrary shapes of nanofibers. Nanofibers design was conducted by electromagnetic simulation. Raman characteristics and stem-cell function have been evaluated in the context of their integration into nanofiber-based single cell analysis.
|
| Academic Significance and Societal Importance of the Research Achievements |
本研究は、量子エレクトロニクス分野で開発してきたナノ光デバイスを、大胆にも幹細胞の
一細胞計測にまで応用しようとする挑戦的な目標を掲げている。ナノ光ファイバは超高効率蛍光検出ナノデバイスとして、既に理論・実験両面でその詳細な動作特性が明らかとなっており、これをニードル化する事に成功した点で、新しいバイオ分析コンセプトを提供している。また幹細胞移植治療でのリモートセンシングを念頭に、再生因子への影響などを解明した点で、バイオ医療応用への方向性を示した点で、将来の分析ツールとして期待される。
|
Report
(4 results)
Research Products
(56 results)
-
-
-
-
-
-
-
-
-
[Journal Article] Fiber-Coupled Diamond Micro-Waveguides toward an Efficient Quantum Interface for Spin Defect Centers2017
Author(s)
Masazumi Fujiwara, Oliver Neitzke, Tim Schroder, Andreas W. Schell, Janik Wolters, Jiabao Zheng, Sara Mouradian, Mohamed Almoktar, Shigeki Takeuchi, Dirk Englund, and Oliver Benson
-
Journal Title
ACS OMEGA
Volume: 2
Issue: 10
Pages: 7194-7202
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
