| Project/Area Number |
16K13727
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Quantum beam science
|
|---|
| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
|---|
Principal Investigator |
ISHIOKA NORIKO 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 上席研究員(定常) (30354963)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
渡辺 茂樹 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 放射線生物応用研究部, 主幹研究員(定常) (10450305)
近藤 浩夫 国立研究開発法人量子科学技術研究開発機構, 六ヶ所核融合研究所 核融合炉材料研究開発部, 主幹研究員(定常) (40403159)
金村 卓治 国立研究開発法人量子科学技術研究開発機構, 六ヶ所核融合研究所 核融合炉材料研究開発部, 研究員(定常) (50751468)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | アスタチン‐211 / ビスマス / アルファビーム / 大量製造 / がん治療 / 液体ビスマス / 循環式標的 / At-211の製造法 |
|---|
| Outline of Final Research Achievements |
Alpha(α)-emitting radionuclide, astatine-211 (211At), has potential as a next-generation anti-cancer drug. The 209Bi(α,2n)211At reaction is required to produce large amount of 211At. However, bismuth (Bi) target is readily melted by an irradiation with high beam current due to its low melting point, which has limited the scale-up of 211At production. Purpose of this study is to formulate and verify an innovative concept for the large amount production of 211At using newly Bi irradiation system. Configuration of the Bi target was studied in terms of local heating by α-beam irradiation and the optimal one was presented. Its prototype was newly fabricated and irradiation tests were implemented with α-beam up to 8 μA by using an AVF cyclotron. As a result, steady irradiation was realized and the concept of the new irradiation system was verified.
|
