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Mathematical modeling for glucose concentration in blood based on inverse problem analysis of fractional differential equations

Research Project

Project/Area Number 16K13774
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Foundations of mathematics/Applied mathematics
Research InstitutionKyoto University

Principal Investigator

ISO Yuusuke  京都大学, 情報学研究科, 教授 (70203065)

Co-Investigator(Kenkyū-buntansha) 藤原 宏志  京都大学, 情報学研究科, 准教授 (00362583)
今井 仁司  同志社大学, 理工学部, 教授 (80203298)
Research Collaborator SHEEN Dongwoo  
HIGASHIMORI Nobuyuki  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords数値解析 / 分数階微分方程式 / 函数方程式 / 数理モデル / 逆問題解析 / 数値計算 / 数理モデル化 / 逆問題
Outline of Final Research Achievements

We have shown some new results both in mathematical and numerical analysis for fractional order ordinary differential equations (F-ODE), which are equivalent to weakly singular integral equation of the Volterra type. We focus on regularity of unknown functions up to the the initial points, and we have clarified assumptions in the fundamental theorem for existence and uniqueness of solutions. We showed new results on numerical instability for a well-known scheme and give a new reliable numerical one. We also focus on limitation of F-ODE as mathematical models for phenomena including glucose concentration.

Academic Significance and Societal Importance of the Research Achievements

分数階方程式を利用した現象の数理モデル化とその解析は、この近年人口に膾炙される傾向にあるが、本課題研究はこれらの研究を支える基盤の一つを構築した。同時に、従来の議論と同様に構成的考察により現象の数理モデル化を論じることには制約があることを示し、data drivenを基本とするdata science的な考え方に基づく数理モデル化での分数階方程式の活用の有効性を示唆した。この成果は先端的な数理科学の基礎研究と応用研究の両面に寄与するものである。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (21 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (14 results) (of which Int'l Joint Research: 12 results,  Invited: 3 results) Funded Workshop (1 results)

  • [Int'l Joint Research] ソウル大学校自然科学大学数理科学部(韓国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Numerical experiments on analyticity of solutions to fractional differential equations2018

    • Author(s)
      H. Fujiwara, N. Higashimori, and H. Imai
    • Journal Title

      Advances in Mathematical Sciences and Applications

      Volume: 27 Pages: 169-180

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Convergence of Finite Difference Schemes Applied to the Cauchy Problems of Quasi-linear Partial Differential Equations of the Normal Form2018

    • Author(s)
      Higashimori Nobuyuki, Fujiwara Hiroshi, Iso Yuusuke
    • Journal Title

      Advances in Difference Equations and Discrete Dynamical Systems

      Volume: - Pages: 113-124

    • DOI

      10.1007/978-981-10-6409-8_6

    • ISBN
      9789811064081, 9789811064098
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multiple-Precision Arithmetic Environment in MATLAB and Its Application to Reliable Computation of Fractional Order Derivatives2018

    • Author(s)
      Hiroshi Fujiwara
    • Journal Title

      マス・フォア・インダストリ研究

      Volume: 8 Pages: 83-120

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Semi-discrete finite difference schemes for the nonlinear Cauchy problems of the normal form2017

    • Author(s)
      Higashimori Nobuyuki, Fujiwara Hiroshi
    • Journal Title

      Proceedings of the Japan Academy, Series A, Mathematical Sciences

      Volume: 93 Issue: 9 Pages: 99-104

    • DOI

      10.3792/pjaa.93.99

    • NAID

      40021392001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 定常輻射輸送方程式の速度方向区分定数近似の数値解析2016

    • Author(s)
      藤原 宏志
    • Journal Title

      計算数理工学論文集

      Volume: 16 Pages: 91-96

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] A proposal of a new numerical algorithm to solve fractional differential equations2018

    • Author(s)
      磯 祐介
    • Organizer
      Japan-Taiwan Joint Workshop on Scientific Computing and Related Topics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Accurate numerical computation for one-dimensional fractional differential equations by using spectral collocation methods2018

    • Author(s)
      今井 仁司
    • Organizer
      Japan-Taiwan Joint Workshop on Scientific Computing and Related Topics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多倍長計算環境exflibの最新計算環境への対応と普及2018

    • Author(s)
      藤原 宏志
    • Organizer
      日本応用数理学会年会2018年度 年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Numerical challenges to the radiative transport equation for near-infrared light propagation in tissue2018

    • Author(s)
      H. Fujiwara
    • Organizer
      Numerical Analysis: Applications to Biomedical Problems and Foundations
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Diffused Optical Tomography as an Inverse Problem for the Transport Equation2017

    • Author(s)
      磯 祐介
    • Organizer
      Korea-Japan Joint Workshop on Numerical Analysis and Scientific Computation
    • Place of Presentation
      Jeju National University Unipark, Seoguipo, Jeju, (大韓民国)
    • Year and Date
      2017-02-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Semi-discrete numerical scheme of the 2D stationary radiative transport equation on highly-parallel architectures2017

    • Author(s)
      藤原 宏志
    • Organizer
      Korea-Japan Joint Workshop on Numerical Analysis and Scientific Computation
    • Place of Presentation
      Jeju National University Unipark, Seoguipo, Jeju,(大韓民国)
    • Year and Date
      2017-02-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Numerical limit and its application to a blow-up problem governed by an ODE system2017

    • Author(s)
      今井 仁司
    • Organizer
      Korea-Japan Joint Workshop on Numerical Analysis and Scientific Computation
    • Place of Presentation
      Jeju National University Unipark, Seoguipo, Jeju, (大韓民国)
    • Year and Date
      2017-02-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 生体内の光伝播の数値計算のための定常輻射輸送方程式の上流差分スキームの数値計算2017

    • Author(s)
      藤原宏志
    • Organizer
      日本計算数理工学会(第33回 計算数理工学フォーラム)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Quantitative simulation of light emitting by optical fibers in the radiative transport equation2017

    • Author(s)
      H. Fujiwara
    • Organizer
      A3 Workshop on Applied Inverse Problems and Related Topics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Direct Numerical Computation of the Stationary Radiative Transport Equation on Modern Parallel Architectures2017

    • Author(s)
      H. Fujiwara, N. Oishi
    • Organizer
      The 16th International Symposium on Distributed Computing and Applications to Business, Engineering and Science
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Semi-discrete upwind finite volume methods for the 2D stationary radiative transport equation by GPGPU2016

    • Author(s)
      藤原 宏志
    • Organizer
      2016 Japan-Taiwan Joint Workshop on Numerical Analysis and Scientif ic Computation
    • Place of Presentation
      Lecture Room 202, Astro-Math Building, National Taiwan University(中華民国)
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Numerical limit and its application to a blow-up problem2016

    • Author(s)
      今井 仁司
    • Organizer
      2016 Japan-Taiwan Joint Workshop on Numerical Analysis and Scientif ic Computation
    • Place of Presentation
      Lecture Room 202, Astro-Math Building, National Taiwan University(中華民国)
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Numerical Computation of the 2D Radiative Transport Equation by Upwind Finite Volume Method2016

    • Author(s)
      藤原 宏志
    • Organizer
      SIAM: East Asian Section Conference 2016
    • Place of Presentation
      University of Macau(中華人民共和国)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Direct computation of the radiative transport equation for near-infrared light propagation in biological tissue2016

    • Author(s)
      藤原 宏志
    • Organizer
      The 11th AIMS Conference on Dynamical Systems, Differential Equations and Applications
    • Place of Presentation
      Hyatt Regency Orland(アメリカ合衆国)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Funded Workshop] Taiwan-Japan Joint Workshop on Inverse Problems and Related Topics in Kyoto 20192019

    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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