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Amino acid synthesis and polymerization in early ocean alkaline hydrothermal systems

Research Project

Project/Area Number 16K13906
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Petrology/Mineralogy/Economic geology
Research InstitutionTokyo Institute of Technology

Principal Investigator

Norio Kitadai  東京工業大学, 地球生命研究所, 研究員 (80625723)

Co-Investigator(Kenkyū-buntansha) 本郷 やよい  東京工業大学, 地球生命研究所, 研究員 (40435681)
Research Collaborator Imai Ei-ich  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords生命の起源 / アストロバイオロジー / 生命の化学進化 / 電気化学 / 初期地球 / 化学進化 / ペプチド
Outline of Final Research Achievements

Deep sea alkaline hydrothermal systems are among the most plausible environments for the origin of life on Earth, and probably so in Universe. Steep pH, temperature, and redox gaps between hydrothermal fluids and seawater generate huge and sustainable thermodynamic disequilibrium at the vent-seawater interface, where CO2 fixation into organic molecules including building blocks of life, and subsequent condensation/polymerization of monomers into functional polymers may have occurred in the aid of catalytic and reductive minerals. Here, we examined this possibility by thermodynamic calculation and laboratory simulations particularly focusing on the amino acid synthesis and polymerization processes. Favorable environmental conditions for the chemical evolution of life in hydrothermal systems were discussed based on the obtained experimental and theoretical results.

Academic Significance and Societal Importance of the Research Achievements

生命起源を巡る議論は大変歴史が深く,古くは紀元前4世紀のアリストテレスによる「自然発生説」を一例として様々なアイデアが提唱されてきた.本研究では深海熱水噴出孔環境が生命誕生に果たした役割を室内実験・理論計算の両面から検証し,本環境が生命の構成分子(アミノ酸など)の生成や重合を促進するメカニズムや条件を評価した.得られた成果は,地球生命がどこでどのように生まれたのか,という根源的謎を解き明かす上で,大きな進展をもたらしたと考えられる.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (22 results)

All 2018 2017 2016

All Journal Article (10 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 6 results) Book (2 results)

  • [Journal Article] Geoelectrochemical CO production: Implications for the autotrophic origin of life2018

    • Author(s)
      Kitadai N., Nakamura R., Yamamoto M., Takai K., Li Y., Yamaguchi A., Gilbert A., Ueno Y., Yoshida N., Oono Y.
    • Journal Title

      Science Advances

      Volume: 4 Issue: 4 Pages: 1-7

    • DOI

      10.1126/sciadv.aao7265

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical diversity of metal sulfide minerals and its implications for the origin of life2018

    • Author(s)
      Li Y., Kitadai N. and Nakamura R.
    • Journal Title

      Life

      Volume: 8 Issue: 4 Pages: 46-46

    • DOI

      10.3390/life8040046

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Geochemistry and the Origin of Life: From Extraterrestrial Processes, Chemical Evolution on Earth, Fossilized Life’s Records, to Natures of the Extant Life2018

    • Author(s)
      Satoru Nakashima, Yoko Kebukawa, Norio Kitadai, Motoko Igisu, Natsuki Matsuoka
    • Journal Title

      Life

      Volume: 8 Issue: 4 Pages: 39-39

    • DOI

      10.3390/life8040039

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amorphous silica-promoted lysine dimerization: A thermodynamic prediction2018

    • Author(s)
      Kitadai N., Nishiuchi K., Nishii A., Fukushi K.
    • Journal Title

      Origin of Life and Evolution of Biospheres

      Volume: 48 Issue: 1 Pages: 23-34

    • DOI

      10.1007/s11084-017-9548-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Origin of the reductive tricarboxylic acid (rTCA) cycle-type CO2 fixation: A perspective2017

    • Author(s)
      Kitadai N., Kameya M., Fujishima K.
    • Journal Title

      Life

      Volume: 7 Issue: 4 Pages: 39-39

    • DOI

      10.3390/life7040039

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Origins of building blocks of life. A review2017

    • Author(s)
      Kitadai N., Maruyama S.
    • Journal Title

      Geoscience Frontiers

      Volume: -

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Glycine polymerization on oxide minerals2017

    • Author(s)
      Kitadai, N., Oonishi H., Umemoto K., Usui T., Fukushi K. and Nakashima S.
    • Journal Title

      Origins of Life and Evolution of Biospheres

      Volume: 印刷中 Issue: 2 Pages: 123-143

    • DOI

      10.1007/s11084-016-9516-z

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dissolved divalent metal and pH effects on amino acid polymerization: A thermodynamic evaluation2017

    • Author(s)
      Kitadai, N.
    • Journal Title

      Origins of Life and Evolution of Biospheres

      Volume: 47 Issue: 1 Pages: 13-37

    • DOI

      10.1007/s11084-016-9510-5

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Predicting thermodynamic behaviors of non-protein amino acids as a function of temperature and pH,2016

    • Author(s)
      Kitadai, N.
    • Journal Title

      Origins of Life and Evolution of Biospheres

      Volume: 46 Issue: 1 Pages: 3-18

    • DOI

      10.1007/s11084-015-9457-y

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Origin of metabolism: A perspective2016

    • Author(s)
      Kitadai, N., Aono, M., Oono, Y.
    • Journal Title

      Chikyukagaku

      Volume: 50 Issue: 3 Pages: 155-176

    • DOI

      10.14934/chikyukagaku.50.155

    • NAID

      130005267120

    • ISSN
      0386-4073, 2188-5923
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 生命発生,特に代謝の起源に関する実験的・理論的研究2018

    • Author(s)
      北台紀夫
    • Organizer
      日本地球化学会第65回年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Geo-electrochemical metal production: Implications for the chemical evolution of life2018

    • Author(s)
      北台紀夫
    • Organizer
      日本地球惑星連合2018年大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アミノ酸の重合挙動から探る生命起源に有利な環境2018

    • Author(s)
      北台紀夫
    • Organizer
      第43回 生命の起源及び進化学会 学術講演会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Origin of life-Driven by geo-electrochemical energy2017

    • Author(s)
      Kitadai N.
    • Organizer
      Japanese-Canadian Frontiers of Science Symposium
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Universality of the origin of life in the Cosmos2017

    • Author(s)
      北台紀夫
    • Organizer
      生命の起源及び進化学会 夏の学校
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Electrochemistry and the origin of life2016

    • Author(s)
      Kitadai N., Yamaguchi A., Li Y., Yamamoto M., Nakamura R and Takai K.
    • Organizer
      Japanese Society of Microbial Ecology (JSME) Annual Meeting
    • Place of Presentation
      Yokosuka, Japan
    • Year and Date
      2016-10-22
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] CO2 fixation in hydrothermal vent environments2016

    • Author(s)
      Kitadai N., Hongo Y., Li Y., Yamaguchi A., Nakamura R. Yamamoto M. and Takai K.
    • Organizer
      Goldschmidt 2016
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mineral-amino acid interactions and origin of life2016

    • Author(s)
      Nishii A., Kitadai N., Tokimori H. and Kurokawa K.
    • Organizer
      Goldschmidt 2016
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Experimental study on atmospheric synthesis of organic compounds: A role of ferruginous ocean2016

    • Author(s)
      Kawade W., Ueno Y., Kitadai N. and Hongo Y.
    • Organizer
      Goldschmidt 2016
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Electrochemical carbon fixation2016

    • Author(s)
      Kitadai N., Hongo Y., Li Y., Yamaguchi A., Nakamura R., Yamamoto M., and Takai K.
    • Organizer
      Japan Geoscience Union Meeting
    • Place of Presentation
      Makuhari, Japan
    • Year and Date
      2016-05-22
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] 生命の起源はどこまでわかったのか 深海と宇宙から迫る2018

    • Author(s)
      高井研
    • Total Pages
      206
    • Publisher
      岩波書店
    • ISBN
      9784000062848
    • Related Report
      2017 Research-status Report
  • [Book] 海と地球の情報誌 Blue Earth 1492017

    • Author(s)
      田代省三
    • Total Pages
      32
    • Publisher
      有限会社フォトンクリエイト
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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